PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

The MAPK signaling cascade

1995 • 3,300 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

1995 • 2,080 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1992 • 1,146 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

1995 • 906 citations

Inactivation of glycogen synthase kinase-3β by phosphorylation: new kinase connections in insulin and growth-factor signalling

1993 • 877 citations

A Specific Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase

1994 • 800 citations

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

1992 • 601 citations

Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.

1994 • 551 citations

MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase.

1992 • 486 citations

The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf

1994 • 476 citations

Tissue distribution of the AMP‐activated protein kinase, and lack of activation by cyclic‐AMP‐dependent protein kinase, studied using a specific and sensitive peptide assay

1989 • 437 citations

Mitogen-activated Protein Kinase Kinase Inhibition Does Not Block the Stimulation of Glucose Utilization by Insulin

1995 • 395 citations

Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines

1995 • 363 citations

Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase.

1993 • 348 citations

[30] Smooth muscle myosin light chain kinase

1983 • 229 citations

Chapter 17 Systems for the Study of Nuclear Assembly, DNA Replication, and Nuclear Breakdown in Xenopus laevis Egg Extracts

1991 • 180 citations

[29] Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf

1995 • 163 citations

Insulin-Stimulated Disassociation of the SOS-Grb2 Complex

1995 • 107 citations

Disassembly of Son-of-sevenless Proteins from Grb2 during p21 Desensitization by Insulin

1995 • 99 citations

Feedback regulation of mitogen-activated protein kinase kinase kinase activity of c-Raf-1 by insulin and phorbol ester stimulation.

1994 • 97 citations

[26] Phosphorylase kinase from rabbit skeletal muscle

1983 • 89 citations

Enzymatic characteristics of the c-Raf-1 proteinkinase.

1994 • 87 citations

Glycogen synthase kinases. Distribution in mammalian tissues of forms that are independent of cyclic AMP.

1977 • 67 citations

Effector‐dependent conformational changes in protein kinase Cγ through epitope mapping with inhibitory monoclonal antibodies

1990 • 47 citations

Identification of a latent MAP kinase kinase kinase in PC12 cells as B‐raf

1994 • 37 citations