Signal transduction in Saccharomyces cerevisiae requires tyrosine and threonine phosphorylation of FUS3 and KSS1.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Transformation of intact yeast cells treated with alkali cations

1983 • 7,688 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites

1988 • 2,903 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

[42] Detection and quantification of phosphotyrosine in proteins

1983 • 1,184 citations

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

1990 • 1,087 citations

Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase).

1991 • 1,041 citations

An Insulin-Stimulated Protein Kinase Similar to Yeast Kinases Involved in Cell Cycle Control

1990 • 701 citations

mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2

1991 • 688 citations

Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases

1991 • 579 citations

The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SW15

1991 • 501 citations

The STE4 and STE18 genes of yeast encode potential β and γ subunits of the mating factor receptor-coupled G protein

1989 • 491 citations

Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function.

1991 • 459 citations

Two genes required for cell fusion during yeast conjugation: evidence for a pheromone-induced surface protein.

1987 • 439 citations

FUS3 encodes a cdc2+/CDC28-related kinase required for the transition from mitosis into conjugation

1990 • 437 citations

The yeast SCG1 gene: A Gα-like protein implicated in the a- and α-factor response pathway

1987 • 431 citations

Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2

1990 • 401 citations

Cell cycle control of the yeast HO gene: Cis- and Trans-acting regulators

1987 • 392 citations

Mutants of Saccharomyces cerevisiae unresponsive to cell division control by polypeptide mating hormone.

1980 • 368 citations

GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction

1987 • 365 citations

The role of SWI4 and SWI6 in the activity of G1 cyclins in yeast

1991 • 354 citations

Cell cycle tyrosine phosphorylation of p34cdc2 and a microtubule-associated protein kinase homolog in Xenopus oocytes and eggs.

1991 • 352 citations

The yeast cell-type-specific repressor α2 acts cooperatively with a non-cell-type-specific protein

1988 • 348 citations

Fission yeast p107wee1 mitotic inhibitor is a tyrosine/serine kinase

1991 • 344 citations

Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation.

1991 • 344 citations

Rational scanning mutagenesis of a protein kinase identifies functional regions involved in catalysis and substrate interactions

1991 • 334 citations

[13] Immunochemical identification of membrane proteins after sodium dodecyl sulfate—polyacrylamide gel electrophoresis

1983 • 309 citations

A putative protein kinase overcomes pheromone-induced arrest of cell cycling in S. cerevisiae

1989 • 298 citations

Yeast has homologs (CNA1 and CNA2 gene products) of mammalian calcineurin, a calmodulin-regulated phosphoprotein phosphatase.

1991 • 297 citations

Regulation of p34CDC28 tyrosine phosphorylation is not required for entry into mitosis in S. cerevisiae

1992 • 296 citations

[5] Assay of yeast mating reaction

1991 • 286 citations

Xenopus M phase MAP kinase: isolation of its cDNA and activation by MPF.

1991 • 274 citations

STE12, a protein involved in cell-type-specific transcription and signal transduction in yeast, is part of protein-DNA complexes.

1989 • 274 citations

Identification and regulation of a gene required for cell fusion during mating of the yeast Saccharomyces cerevisiae.

1987 • 253 citations

Conjugation in Saccharomyces cerevisiae

1988 • 248 citations

The yeast STE12 protein binds to the DNA sequence mediating pheromone induction.

1989 • 245 citations

Signal Transduction During Pheromone Response in Yeast

1991 • 225 citations

Cyclin promotes the tyrosine phosphorylation of p34cdc2 in a wee1+ dependent manner.

1991 • 218 citations

The identification of a second cell cycle control on the HO promoter in yeast: Cell cycle regulation of SWI5 nuclear entry

1990 • 215 citations

FUS3 represses CLN1 and CLN2 and in concert with KSS1 promotes signal transduction.

1991 • 211 citations

Tyrosine phosphorylation and activation of homologous protein kinases during oocyte maturation and mitogenic activation of fibroblasts.

1991 • 202 citations

A yeast operator overlaps an upstream activation site

1987 • 200 citations

Nucleotide sequence of the yeast regulatory gene STE7 predicts a protein homologous to protein kinases.

1986 • 189 citations

STE11 is a protein kinase required for cell-type-specific transcription and signal transduction in yeast.

1990 • 178 citations

Chapter 4 Preparation of RNA and Ribosomes from Yeast

1975 • 171 citations

Pheromone-dependent phosphorylation of the yeast STE12 protein correlates with transcriptional activation.

1991 • 148 citations

Stoichiometry of G protein subunits affects the Saccharomyces cerevisiae mating pheromone signal transduction pathway.

1990 • 146 citations

Overexpression of the STE4 gene leads to mating response in haploid Saccharomyces cerevisiae.

1990 • 145 citations

Autophosphorylation in vitro of recombinant 42-kilodalton mitogen-activated protein kinase on tyrosine.

1991 • 143 citations

Constitutive mutants in the yeast pheromone response: Ordered function of the gene products

1989 • 143 citations

The yeast MCK1 gene encodes a protein kinase homolog that activates early meiotic gene expression.

1991 • 142 citations

Overproduction of the yeast STE12 protein leads to constitutive transcriptional induction.

1990 • 133 citations

Spk1, a New Kinase from Saccharomyces cerevisiae, Phosphorylates Proteins on Serine, Threonine, and Tyrosine

1991 • 130 citations

Genetic and environmental control of flowering time in Arabidopsis

1995 • 126 citations

Cell-type-specific transcription in yeast

1991 • 125 citations

A suppressor of a centromere DNA mutation encodes a putative protein kinase (MCK1).

1991 • 111 citations

Role of STE genes in the mating factor signaling pathway mediated by GPA1 in Saccharomyces cerevisiae.

1988 • 107 citations

Pheromone-induced phosphorylation of a G protein β subunit in S. cerevisiae is associated with an adaptive response to mating pheromone

1991 • 96 citations

Yeast STE7, STE11, and STE12 genes are required for expression of cell-type-specific genes.

1988 • 92 citations

Multiple regulation of STE2, a mating-type-specific gene of Saccharomyces cerevisiae.

1986 • 88 citations

SGV1 encodes a CDC28/cdc2-related kinase required for a Gα subunit-mediated adaptive response to pheromone in S. cerevisiae

1991 • 79 citations

Identification of electrostatic interactions that determine the phosphorylation site specificity of the cAMP-dependent protein kinase

1991 • 75 citations

Molecular cloning of the DAC2/FUS3 gene essential for pheromone-induced G1-arrest of the cell cycle in Saccharomyces cerevisiae

1990 • 20 citations

A yeast-Escherichia coli shuttle vector containing the M13 origin of replication

1990 • 18 citations

MAP kinase activation

1991 • 17 citations