cAMP abrogates the p21ras-mitogen-activated protein kinase pathway in fibroblasts.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

Early Signals in the Mitogenic Response

1986 • 1,498 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1993 • 1,077 citations

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 • 1,026 citations

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

1992 • 948 citations

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1993 • 876 citations

Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

1989 • 846 citations

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

1993 • 730 citations

Na+/H+ exchange and cytoplasmic pH in the action of growth factors in human fibroblasts

1983 • 721 citations

Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

1992 • 714 citations

Role of Cyclic Nucleotides in Growth Control

1975 • 692 citations

The bioactive phospholipid lysophosphatidic acid is released from activated platelets

1993 • 653 citations

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

1993 • 587 citations

Effects of Growth Factors on Intracellular pH Regulation

1986 • 498 citations

Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein.

1992 • 490 citations

A sensitive method for detection of calmodulin-dependent protein kinase II activity in sodium dodecyl sulfate-polyacrylamide gel

1989 • 466 citations

Extracellular signals and reversible protein phosphorylation: What to Mek of it all

1993 • 426 citations

Involvement of p21ras in activation of extracellular signal-regulated kinase 2

1992 • 403 citations

Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts.

1993 • 377 citations

RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts.

1993 • 356 citations

Lysophosphatidates bound to serum albumin activate membrane currents in Xenopus oocytes and neurite retraction in PC12 pheochromocytoma cells.

1992 • 355 citations

Epidermal Growth Factor: Receptors in Human Fibroblasts and Modulation of Action by Cholera Toxin

1973 • 328 citations

The mitogen-activated protein kinase activator

1992 • 285 citations

Insulin stimulation of gene expression mediated by p21ras activation.

1991 • 284 citations

Accumulation of p21ras.GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity.

1990 • 264 citations

Lysophosphatidic acid, but not phosphatidic acid, is a potent Ca2(+)-mobilizing stimulus for fibroblasts. Evidence for an extracellular site of action.

1990 • 264 citations

Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the Gi-p21ras pathway.

1994 • 239 citations

Cellular transformation and the ‘morphologic phenotype’ of transformed cells

1978 • 138 citations

Prostaglandin E1 inhibits DNA synthesis in arterial smooth muscle cells stimulated with platelet-derived growth factor

1984 • 123 citations

Structure function of the growth factor-activatable Na+/H+ exchanger (NHE1)

1992 • 92 citations

Rap1-b is phosphorylated by protein kinase a in intact human platelets

1990 • 90 citations

Complementation of byrl in fission yeast by mammalian MAP kinase kinase requires coexpression of Raf kinase

1993 • 73 citations

Induction of cyclic AMP synthesis by forskolin is followed by a reduction in the expression of c‐myc messenger RNA and inhibition of ³H‐thymidine incorporation in human fibroblasts

1989 • 72 citations

Cyclic AMP‐mediated suppression of normal and neoplastic B cell proliferation is associated with regulation of myc and Ha‐ras protooncogenes

1987 • 68 citations

Cyclic AMP inhibits mitogen‐induced DNA synthesis in hamster fibroblasts, regardless of the signalling pathway involved

1989 • 67 citations

Reverse transformation of Harvey murine sarcoma virus-transformed NIH/3T3 cells by site-selective cyclic AMP analogs.

1988 • 57 citations

Possible Involvement of Normal p21 H-ras in the Insulin/Insulinlike Growth Factor 1 Signal Transduction Pathway

1989 • 52 citations

Phosphorylation of rap1GAP in vivo and by cAMP-dependent kinase and the cell cycle p34cdc2 kinase in vitro.

1992 • 36 citations

Dissociation of platelet-derived growth factor (PDGF) receptor autophosphorylation from other PDGF-mediated second messenger events

1991 • 27 citations

Reverse transformation of vole cells transformed by avian sarcoma virus containing the src gene

1981 • 25 citations