Apoptosis Induced by Withdrawal of Trophic Factors Is Mediated by p38 Mitogen-activated Protein Kinase

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

1997 • 2,284 citations

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

1995 • 2,080 citations

How MAP Kinases Are Regulated

1995 • 1,742 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway

1996 • 1,286 citations

Sounding the Alarm: Protein Kinase Cascades Activated by Stress and Inflammation

1996 • 1,099 citations

Parallel signal processing among mammalian MAPKs

1995 • 1,015 citations

Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

1997 • 770 citations

The pathway to signal achievement

1993 • 563 citations

Characterization of the Structure and Function of a Novel MAP Kinase Kinase (MKK6)

1996 • 519 citations

A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.

1987 • 403 citations

A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket

1997 • 387 citations

Fas Activation of the p38 Mitogen-Activated Protein Kinase Signalling Pathway Requires ICE/CED-3 Family Proteases

1997 • 285 citations

Osmotic regulation of cytokine synthesis in vitro.

1995 • 282 citations

Thrombin Induces Activation of p38 MAP Kinase in Human Platelets

1995 • 209 citations

Shc is the predominant signaling molecule coupling insulin receptors to activation of guanine nucleotide releasing factor and p21ras-GTP formation.

1994 • 200 citations

Mitogen-activated Protein Kinase-independent Pathways Mediate the Effects of Nerve Growth Factor and cAMP on Neuronal Survival

1996 • 176 citations

Inhibition of p38 Mitogen-activated Protein Kinase by Insulin in Cultured Fetal Neurons

1996 • 109 citations

Growth Factors Rescue Embryonic Dopamine Neurons from Programmed Cell Death

1996 • 73 citations

Functional Properties of the Subtype of Insulin Receptor Found on Neurons

1988 • 64 citations

Divergence of signaling pathways for insulin in PC-12 pheochromocytoma cells.

1993 • 45 citations