Immune escape of tumors: apoptosis resistance and tumor counterattack

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

2000 • 3,415 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

1997 • 3,167 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

2001 • 2,658 citations

Inhibition of death receptor signals by cellular FLIP

1997 • 2,577 citations

IAP family proteins---suppressors of apoptosis

1999 • 2,570 citations

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

2000 • 2,344 citations

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.

1995 • 2,142 citations

NADPH Oxidase: An Update

1999 • 2,134 citations

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

1995 • 2,028 citations

Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells

1996 • 1,908 citations

Regulatory T Cells

2000 • 1,827 citations

Involvement of the bcl -2 Gene in Human Follicular Lymphoma

1985 • 1,797 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

The Concept of Immunological Surveillance

2015 • 1,586 citations

Colony-Stimulating Factor 1 Promotes Progression of Mammary Tumors to Malignancy

2001 • 1,556 citations

Inside the Neutrophil Phagosome: Oxidants, Myeloperoxidase, and Bacterial Killing

1998 • 1,443 citations

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

1995 • 1,346 citations

Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype

1997 • 1,329 citations

Progress in human tumour immunology and immunotherapy

2001 • 1,327 citations

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

1997 • 1,305 citations

Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape

1996 • 1,281 citations

bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1989 • 1,252 citations

Inside the Neutrophil Phagosome: Oxidants, Myeloperoxidase, and Bacterial Killing

1998 • 1,249 citations

Tumor Antigens Recognized by T Lymphocytes

1994 • 1,238 citations

A role for CD95 ligand in preventing graft rejection

1995 • 1,184 citations

Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients

1999 • 1,131 citations

Protection from Fas-Mediated Apoptosis by a Soluble Form of the Fas Molecule

1994 • 1,120 citations

Neutrophils: Molecules, Functions and Pathophysiological Aspects

2000 • 1,104 citations

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

1992 • 1,076 citations

The mitochondrion in apoptosis: how Pandora's box opens

2001 • 1,035 citations

Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells

1996 • 1,001 citations

Apo2L/TRAIL-Dependent Recruitment of Endogenous FADD and Caspase-8 to Death Receptors 4 and 5

2000 • 968 citations

Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

2001 • 960 citations

Breaking the mitochondrial barrier

2001 • 947 citations

Lymphocyte apoptosis induced by CD95 (APO–1/Fas) ligand–expressing tumor cells — A mechanism of immune evasion?

1996 • 917 citations

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2

1990 • 910 citations

The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand.

1996 • 894 citations

Human tumor antigens recognized by T lymphocytes.

1996 • 860 citations

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

1994 • 844 citations

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity.

1993 • 801 citations

Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN

2000 • 799 citations

FADD/MORT1 and Caspase-8 Are Recruited to TRAIL Receptors 1 and 2 and Are Essential for Apoptosis Mediated by TRAIL Receptor 2

2000 • 792 citations

Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer

1998 • 781 citations

Implications for immunosurveillance of altered HLA class I phenotypes in human tumours

1997 • 769 citations

Cooperative interaction between c-myc and bcl-2 proto-oncogenes

1992 • 766 citations

Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells

2001 • 759 citations

Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells

2001 • 757 citations

Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53.

1997 • 749 citations

High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy

1993 • 738 citations

A fresh look at tumor immunosurveillance and immunotherapy

2001 • 723 citations

The Apoptosis Inhibitor Gene API2 and a Novel 18q Gene,MLT, Are Recurrently Rearranged in the t(11;18)(q21;q21) Associated With Mucosa-Associated Lymphoid Tissue Lymphomas

1999 • 714 citations

Induction of antigen-specific T cell anergy: An early event in the course of tumor progression

1998 • 710 citations

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

1994 • 708 citations

Retinoic Acid Early Inducible Genes Define a Ligand Family for the Activating NKG2D Receptor in Mice

2000 • 694 citations

Intracellular Regulation of TRAIL-Induced Apoptosis in Human Melanoma Cells

1998 • 671 citations

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

1997 • 648 citations

Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells.

1993 • 643 citations

The role of nitric oxide in innate immunity

2000 • 642 citations

Identification of human cancers deficient in antigen processing.

1993 • 625 citations

Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death.

1993 • 602 citations

Chemotherapy augments TRAIL-induced apoptosis in breast cell lines.

1999 • 557 citations

FLICE-Inhibitory Proteins: Regulators of Death Receptor-Mediated Apoptosis

2001 • 550 citations

Perforin-Mediated Cytotoxicity Is Critical for Surveillance of Spontaneous Lymphoma

2000 • 540 citations

Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy

2000 • 526 citations

Death Receptor Recruitment of Endogenous Caspase-10 and Apoptosis Initiation in the Absence of Caspase-8

2001 • 521 citations

Roles of tumour localization, second signals and cross priming in cytotoxic T-cell induction

2001 • 500 citations

Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (Trail) Contributes to Interferon γ–Dependent Natural Killer Cell Protection from Tumor Metastasis

2001 • 499 citations

Inhibition of cytotoxic T cell development by transforming growth factor beta and reversal by recombinant tumor necrosis factor alpha.

1987 • 497 citations

bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice

1998 • 496 citations

bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs.

1992 • 487 citations

Decreased tumor surveillance in perforin-deficient mice.

1996 • 487 citations

Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma.

1995 • 477 citations

Activation interferes with the APO-1 pathway in mature human T cells

1993 • 466 citations

Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover.

1996 • 464 citations

Immune surveillance against a solid tumor fails because of immunological ignorance

1999 • 463 citations

Prevention of Islet Allograft Rejection with Engineered Myoblasts Expressing FasL in Mice

1996 • 456 citations

The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis

2001 • 454 citations

Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction

1997 • 453 citations

Critical Role for Tumor Necrosis Factor–related Apoptosis-inducing Ligand in Immune Surveillance Against Tumor Development

2002 • 447 citations

Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis

1997 • 433 citations

Tumor-induced immune dysfunction: the macrophage connection

1998 • 433 citations

The Inhibitor of Death Receptor Signaling, Flice-Inhibitory Protein Defines a New Class of Tumor Progression Factors

1999 • 425 citations

Prognostic significance of bcl-2 protein expression in aggressive non- Hodgkin's lymphoma. Groupe d'Etude des Lymphomes de l'Adulte (GELA)

1996 • 424 citations

Expression of bcl-xL can confer a multidrug resistance phenotype

1995 • 421 citations

Prognostic significance of bcl-2 protein expression in aggressive non- Hodgkin's lymphoma. Groupe d'Etude des Lymphomes de l'Adulte (GELA)

1996 • 419 citations

The intriguing role of polymorphonuclear neutrophils in antitumor reactions

2001 • 411 citations

A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance.

1990 • 409 citations

CD95(APO-1/Fas)-Mediated Apoptosis: Live and Let Die

1998 • 405 citations

Fas ligand expression by astrocytoma in vivo: maintaining immune privilege in the brain?

1997 • 403 citations

How do cytotoxic lymphocytes kill their targets?

1998 • 398 citations

CD95-Induced Apoptosis of Lymphocytes in an Immune Privileged Site Induces Immunological Tolerance

1996 • 394 citations

B cells inhibit induction of T cell-dependent tumor immunity

1998 • 393 citations

Regulation of the Proinflammatory Effects of Fas Ligand (CD95L)

1998 • 391 citations

THE CENTRAL EFFECTORS OF CELL DEATH IN THE IMMUNE SYSTEM

1999 • 390 citations

Caspase 1-independent IL-1β release and inflammation induced by the apoptosis inducer Fas ligand

1998 • 377 citations

CD95 ligand (FasL)-induced apoptosis is necessary for corneal allograft survival.

1997 • 375 citations

Transgenic expression of CD95 ligand on islet β cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts

1997 • 373 citations

I-FLICE, a Novel Inhibitor of Tumor Necrosis Factor Receptor-1- and CD-95-induced Apoptosis

1997 • 372 citations

A Newly Identified Member of Tumor Necrosis Factor Receptor Superfamily (TR6) Suppresses LIGHT-mediated Apoptosis

1999 • 370 citations

HLA class I antigen downregulation in human cancers: T-cell immunotherapy revives an old story

1999 • 366 citations

RNA interference: listening to the sound of silence.

2001 • 365 citations

The host—tumor immune conflict: from immunosuppression to resistance and destruction

1997 • 363 citations

Natural cytotoxicity receptors that trigger human NK-cell-mediated cytolysis

2000 • 358 citations

Subversion of immune system by tumor cells and role of prostaglandins.

1975 • 355 citations

Kaposi's sarcoma-associated herpesvirus encodes a functional Bcl-2 homologue

1997 • 352 citations

Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors

2001 • 347 citations

Immune Escape of Tumors in Vivo by Expression of Cellular Flice-Inhibitory Protein

1999 • 337 citations

Mcl-1, a Bcl-2 Family Member, Delays the Death of Hematopoietic Cells Under a Variety of Apoptosis-Inducing Conditions

1997 • 336 citations

Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity

1994 • 334 citations

Loss of transporter protein, encoded by the TAP-1 gene, is highly correlated with loss of HLA expression in cervical carcinomas.

1994 • 333 citations

The Fas Counterattack In Vivo: Apoptotic Depletion of Tumor-Infiltrating Lymphocytes Associated with Fas Ligand Expression by Human Esophageal Carcinoma

1998 • 331 citations

Antitumor effect of locally produced CD95 ligand

1997 • 315 citations

Interleukin 10 pretreatment protects target cells from tumor- and allo-specific cytotoxic T cells and downregulates HLA class I expression.

1994 • 314 citations

Expression of APO‐1 (CD95), a member of the NGF/TNF receptor superfamily, in normal and neoplastic colon epithelium

1994 • 310 citations

Granzyme B–Mediated Cytochrome C Release Is Regulated by the Bcl-2 Family Members Bid and Bax

2000 • 306 citations

Inhibition of natural killer cells by a cytomegalovirus MHC class I homologue in vivo

1997 • 305 citations

Cancer gene therapy using a survivin mutant adenovirus

2001 • 302 citations

Is cancer dangerous to the immune system?

1996 • 296 citations

Selective Regulation of Apoptosis: the Cytotoxic Lymphocyte Serpin Proteinase Inhibitor 9 Protects against Granzyme B-Mediated Apoptosis without Perturbing the Fas Cell Death Pathway

1998 • 295 citations

Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity

1994 • 294 citations

Hematopoietic Malignancies Demonstrate Loss-of-Function Mutations ofBAX

1998 • 291 citations

Inhibition of melanoma tumor growth in vivo by survivin targeting

2001 • 290 citations

CTLA-4 Blockade Reverses CD8+ T Cell Tolerance to Tumor by a CD4+ T Cell– and IL-2-Dependent Mechanism

1999 • 287 citations

Tumor escape from immune recognition: lethal recurrent melanoma in a patient associated with downregulation of the peptide transporter protein TAP-1 and loss of expression of the immunodominant MART-1/Melan-A antigen.

1996 • 285 citations

Cancer gene therapy using a survivin mutant adenovirus

2001 • 283 citations

Genetic analysis of chemoresistance in primary murine lymphomas

2000 • 276 citations

TGF-beta contributes to the shift toward Th2-type responses through direct and IL-10-mediated pathways in tumor-bearing mice.

1996 • 274 citations

Regulation of death receptor-mediated apoptosis pathways

2000 • 271 citations

Transforming growth factor-beta-induced inhibition of T cell function. Susceptibility difference in T cells of various phenotypes and functions and its relevance to immunosuppression in the tumor-bearing state.

1991 • 266 citations

Inhibition of Natural Killer Cell–Mediated Cytotoxicity by Kaposi's Sarcoma–Associated Herpesvirus K5 Protein

2000 • 258 citations

Protooncogene bcl-2 gene transfer abrogates Fas/APO-1 antibody-mediated apoptosis of human malignant glioma cells and confers resistance to chemotherapeutic drugs and therapeutic irradiation.

1995 • 258 citations

Receptor-stimulated death pathway is opened by antigen in mature T cells.

1991 • 255 citations

Gene transfer of Fas ligand induces tumor regression in vivo

1997 • 247 citations

FLIP Prevents Apoptosis Induced by Death Receptors But Not by Perforin/Granzyme B, Chemotherapeutic Drugs, and Gamma Irradiation

1998 • 247 citations

Inhibition of cell growth and induction of apoptotic cell death by the human tumor-associated antigen RCAS1

1999 • 245 citations

Tumor-induced immune dysfunction

1999 • 239 citations

Target Cell Lysis by CTL Granule Exocytosis Is Independent of ICE/Ced-3 Family Proteases

1997 • 237 citations

Opposing Effects of Transmembrane and Soluble FAS Ligand Expression on Inflammation and Tumor Cell Survival

2000 • 236 citations

Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution

2000 • 234 citations

Role of transforming growth factor beta in cancer

2001 • 232 citations

FAS Engagement Induces the Maturation of Dendritic Cells (Dcs), the Release of Interleukin (Il)-1β, and the Production of Interferon γ in the Absence of IL-12 during Dc–T Cell Cognate Interaction

2000 • 230 citations

Mutations of tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) and receptor 2 (TRAIL-R2) genes in metastatic breast cancers.

2001 • 230 citations

Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster

2000 • 229 citations

Mutations in the Fas Antigen in Patients With Multiple Myeloma

1997 • 228 citations

A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity.

1994 • 224 citations

Bcl-xL is expressed in neuroblastoma cells and modulates chemotherapy-induced apoptosis.

1995 • 220 citations

Multiple levels of peripheral tolerance

1993 • 216 citations

TAP off - tumors on

1997 • 215 citations

The Survivin saga goes in vivo

2001 • 212 citations

Expression and Regulation of Bcl-2, Bcl-xl, and Bax Correlate With p53 Status and Sensitivity to Apoptosis in Childhood Acute Lymphoblastic Leukemia

1997 • 212 citations

Apoptosis signaling in lymphocytes

1999 • 212 citations

Clinical relevance of BCL-2 overexpression in childhood acute lymphoblastic leukemia

1996 • 211 citations

Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes

1999 • 207 citations

Antigenic Cancer Cells Grow Progressively in Immune Hosts without Evidence for T Cell Exhaustion or Systemic Anergy

1997 • 205 citations

Soluble decoy receptor 3 is expressed by malignant gliomas and suppresses CD95 ligand-induced apoptosis and chemotaxis.

2001 • 203 citations

Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53

2001 • 198 citations

Differential regulation of TRAIL and CD95 ligand in transformed cells of the T and B lymphocyte lineage

1998 • 195 citations

Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice.

1996 • 192 citations

Immunity against cancer: lessons learned from melanoma

2001 • 190 citations

Endothelial vascular cell adhesion molecule 1 expression is suppressed by melanoma and carcinoma.

1995 • 189 citations

Identification of an Epstein-Barr virus early gene encoding a second component of the restricted early antigen complex

1987 • 183 citations

Mutations in the Fas Antigen in Patients With Multiple Myeloma

1997 • 183 citations

Spontaneous Development of Plasmacytoid Tumors in Mice with Defective Fas–Fas Ligand Interactions

1998 • 181 citations

A Single Residue Exchange Within a Viral CTL Epitope Alters Proteasome-Mediated Degradation Resulting in Lack of Antigen Presentation

1996 • 181 citations

Oncogenic potential of bcl-2 demonstrated by gene transfer

1988 • 180 citations

Soluble Fas Ligand Is Chemotactic for Human Neutrophilic Polymorphonuclear Leukocytes

1999 • 175 citations

Fas ligand and Fas are expressed constitutively in human astrocytes and the expression increases with IL-1, IL-6, TNF-alpha, or IFN-gamma.

1999 • 174 citations

Neutrophil antibacterial peptides, multifunctional effector molecules in the mammalian immune system

1999 • 173 citations

Fas/Apo-1 (CD95) receptor lacking the intracytoplasmic signaling domain protects tumor cells from Fas-mediated apoptosis.

1996 • 169 citations

Stroma is critical for preventing or permitting immunological destruction of antigenic cancer cells.

1992 • 169 citations

Deficiency of Transporter for Antigen Presentation (TAP) in Tumor Cells Allows Evasion of Immune Surveillance and Increases Tumorigenesis

1999 • 167 citations

Peripheral T cell tolerance as a tumor escape mechanism: deletion of CD4⁺ T cells specific for a monoclonal immunoglobulin idiotype secreted by a plasmacytoma

1996 • 165 citations

Tumor Gangliosides Inhibit the Tumor-Specific Immune Response

1999 • 164 citations

Alterations of the DR5/TRAIL receptor 2 gene in non-small cell lung cancers.

1999 • 162 citations

Rare loss-of-function mutation of a death receptor gene in head and neck cancer.

1998 • 160 citations

Chemotactic activity of soluble Fas ligand against phagocytes.

1998 • 159 citations

Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas

1999 • 159 citations

Cleavage of FLICE (caspase‐8) by granzyme B during cytotoxic T lymphocyte‐induced apoptosis

1997 • 158 citations

Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: a novel protective mechanism for tumor cells to circumvent the immune system?

2002 • 156 citations

Up-regulation of c-FLIPshort and reduction of activation-induced cell death in CD28-co-stimulated human T cells

2000 • 153 citations

Religation of the T cell receptor after primary activation of mature T cells inhibits proliferation and induces apoptotic cell death.

1993 • 152 citations

Selective changes in expression of HLA class I polymorphic determinants in human solid tumors.

1989 • 150 citations

Fas Ligand Engagement of Resident Peritoneal Macrophages In Vivo Induces Apoptosis and the Production of Neutrophil Chemotactic Factors

2001 • 146 citations

Tumor Immunology

1998 • 146 citations

Nucleotide substitution in the ectodomain of trail receptor DR4 is associated with lung cancer and head and neck cancer.

2001 • 144 citations

Beta 2-microglobulin gene mutations: a study of established colorectal cell lines and fresh tumors.

1994 • 143 citations

Elevated soluble Fas (sFas) levels in nonhematopoietic human malignancy.

1996 • 142 citations

Fas Ligand and Fas Are Expressed Constitutively in Human Astrocytes and the Expression Increases with IL-1, IL-6, TNF-α, or IFN-γ

1999 • 142 citations

TCR-Mediated Up-Regulation of c-FLIPshort Correlates with Resistance Toward CD95-Mediated Apoptosis by Blocking Death-Inducing Signaling Complex Activity

2000 • 141 citations

Modulation of Caspase-8 and FLICE-Inhibitory Protein Expression as a Potential Mechanism of Epstein-Barr Virus Tumorigenesis in Burkitt’s Lymphoma

1999 • 140 citations

Constitutive Expression of Fas (Apo-1/CD95) Ligand on Multiple Myeloma Cells: A Potential Mechanism of Tumor-Induced Suppression of Immune Surveillance

1997 • 139 citations

Epstein-Barr Virus BHRF1 Protein Protects against Cell Death Induced by DNA-Damaging Agents and Heterologous Viral Infection

1994 • 136 citations

Immunological escape mechanism in spontaneously metastasizing mammary tumors.

1975 • 131 citations

Profiles of prostaglandin biosynthesis in normal lung and tumor tissue from lung cancer patients.

1988 • 131 citations

Tumor expression of Fas ligand (CD95L) and the consequences

1998 • 126 citations

Fas Gene Mutation in the Progression of Adult T Cell Leukemia

1999 • 124 citations

Assembly and regulation of NADPH oxidase and nitric oxide synthase

1994 • 123 citations

Cutting Edge: Chemotactic Activity of Soluble Fas Ligand Against Phagocytes

1998 • 123 citations

How tumors escape immune destruction and what we can do about it

1999 • 122 citations

Bcl-2 Cooperates with Promyelocytic Leukemia Retinoic Acid Receptor α Chimeric Protein (Pmlrarα) to Block Neutrophil Differentiation and Initiate Acute Leukemia

2001 • 110 citations

Multiple tumour-specific antigens expressed on a single tumour cell

1983 • 107 citations

Impaired binding of perforin on the surface of tumor cells is a cause of target cell resistance against cytotoxic effector cells

2000 • 105 citations

Modulation of L-selectin ligand expression during an immune response accompanying tumorigenesis in transgenic mice.

1996 • 101 citations

LMP-associated proteolytic activities and TAP-dependent peptide transport for class 1 MHC molecules are suppressed in cell lines transformed by the highly oncogenic adenovirus 12.

1996 • 99 citations

Immunological ignorance of silent antigens as an explanation of tumor evasion

1998 • 93 citations

A Model for CD8+ CTL Tumor Immunosurveillance and Regulation of Tumor Escape by CD4 T Cells Through an Effect on Quality of CTL

1999 • 92 citations

Immunoregulation in cancer-bearing hosts. Down-regulation of gene expression and cytotoxic function in CD8+ T cells.

1992 • 92 citations

Fas antigen expression and its relationship with apoptosis in human hepatocellular carcinoma and noncancerous tissues.

1996 • 91 citations

Accelerated Rejection of FAS Ligand-Expressing Heart Grafts

1999 • 91 citations

Induction of Antitumor Immunity with Fas/APO-1 Ligand (CD95L)-Transfected Neuroblastoma Neuro-2a Cells

1999 • 90 citations

Tumor escape mechanisms from immunosurveillance: induction of unresponsiveness in a specific MHC-restricted CD4⁺; human T cell clone by the autologous MHC class II⁺ melanoma

1993 • 90 citations

Role of tumor-derived cytokines on the immune system of mice bearing a mammary adenocarcinoma. II. Down-regulation of macrophage-mediated cytotoxicity by tumor-derived granulocyte-macrophage colony-stimulating factor.

1991 • 88 citations

Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potentin vivo anti-tumor capacity

2001 • 87 citations

The membrane-bound but not the soluble form of human Fas ligand is responsible for its inflammatory activity

2001 • 86 citations

The role of the Fas lytic pathway in a perforin-less CTL hybridoma.

1994 • 86 citations

Inhibition of the alloantibody response by CD95 ligand

1997 • 85 citations

Increased soluble CD95 (sFas/CD95) serum level correlates with poor prognosis in melanoma patients.

2001 • 84 citations

Immune evasion by tumours: involvement of the CD95 (APO-1/Fas) system and its clinical implications

1998 • 83 citations

M144, a Murine Cytomegalovirus (Mcmv)-Encoded Major Histocompatibility Complex Class I Homologue, Confers Tumor Resistance to Natural Killer Cell–Mediated Rejection

1999 • 79 citations

Identification of Tumor-Infiltrating Macrophages as the Killers of Tumor Cells After Immunization in a Rat Model System

2001 • 77 citations

The Regulation of CD95 Ligand Expression and Function in CTL

1998 • 73 citations

A potential immune escape mechanism by melanoma cells through the activation of chemokine-induced T cell death

2001 • 69 citations

Tumor counterattack - concept and reality

2000 • 69 citations

Molecular insights into the immunopathogenesis of follicular lymphoma

2000 • 68 citations

Altered binding of regulatory factors to HLA class I enhancer sequence in human tumor cell lines lacking class I antigen expression.

1992 • 68 citations

Different susceptibility of cytotoxic T cells to CD95 (Fas/Apo-1) ligand-mediated cell death after activation in vitro versus in vivo.

1996 • 67 citations

Clonal deletion of thymocytes as a tumor escape mechanism

1998 • 65 citations

A tumor escape variant that has lost one major histocompatibility complex class I restriction element induces specific CD8+ T cells to an antigen that no longer serves as a target.

1993 • 62 citations

In vivo administration of histoincompatible lymphocytes leads to rapid functional deletion of cytotoxic T lymphocyte precursors.

1989 • 62 citations

Prostaglandin E Production by Lewis Lung Carcinoma: Mechanism for Tumor Establishment In Vivo<xref ref-type="fn" rid="FN2">2</xref>

1984 • 61 citations

A regulatory element in the CD95 (APO-1/Fas) ligand promoter is essential for responsiveness to TCR-mediated activation

1998 • 59 citations

Immunologic Nonresponsiveness to Tumors

1998 • 54 citations

Differential induction of prostaglandin E2-dependent and -independent immune suppressor cells by tumor-derived GM-CSF and M-CSF

1993 • 53 citations

Microsatellite Instability and Frameshift Mutations in BAX and Transforming Growth Factor-β RII Genes Are Very Uncommon in Acute Lymphoblastic Leukemia In Vivo But Not in Cell Lines

1998 • 52 citations

A “Stealth Effect”: Adenocarcinoma Cells Engineered to Express TRAIL Elude Tumor-Specific and Allogeneic T Cell Reactions

1999 • 51 citations

Escape mechanisms of melanoma from immune system by soluble melanoma antigen.

1988 • 47 citations

Loss of CD95 expression is linked to most but not all p53 mutants in European hepatocellular carcinoma

2001 • 43 citations

CD95 Ligand-Expressing Tumors Are Rejected in Anti-Tumor TCR Transgenic Perforin Knockout Mice

2001 • 42 citations

UTILITY OF ADENOVIRAL-MEDIATED FAS LIGAND GENE TRANSFER TO MODULATE ISLET ALLOGRAFT SURVIVAL1

1998 • 42 citations

A NON-CLEAVABLE MUTANT OF FAS LIGAND DOES NOT PREVENT NEUTROPHILIC DESTRUCTION OF ISLET TRANSPLANTS1

2000 • 41 citations

Resistance to CD95 (APO-1/Fas)-mediated apoptosis in human renal cell carcinomas: an important factor for evasion from negative growth control.

1999 • 40 citations

Autoaggression and tumor rejection: it takes more than self‐specific T‐cell activation

1999 • 39 citations

Deficient Major Histocompatibility Complex Class II Antigen Presentation in a Subset of Hodgkin's Disease Tumor Cells

1998 • 38 citations

The Immunology of Corneal Graft Rejection

1998 • 34 citations

Constitutive Expression of Fas (Apo-1/CD95) Ligand on Multiple Myeloma Cells: A Potential Mechanism of Tumor-Induced Suppression of Immune Surveillance

1997 • 30 citations

Distinct Molecular Mechanisms of Fas Resistance in Murine B Lymphoma Cells

2000 • 27 citations

Impaired binding of perforin on the surface of tumor cells is a cause of target cell resistance against cytotoxic effector cells

2000 • 25 citations

Primary virus-induced lymphomas evade T cell immunity by failure to express viral antigens.

1989 • 22 citations

Specific and nonspecific immunity in the prevention of spontaneous tumours

1999 • 21 citations

Inhibition of the Death Receptor Pathway by cFLIP Confers Partial Engraftment of MHC Class I-Deficient Stem Cells and Reduces Tumor Clearance in Perforin-Deficient Mice

2001 • 20 citations

Antigenic modulation as a mechanism for tumor escape from immune destruction: identification of modulation-positive and modulation-negative mouse lymphomas with xenoantisera to murine leukemia virus gp70.

1980 • 19 citations

Exposing tumor cells to killer cell attack

2000 • 17 citations

CD95 Ligand expression enhances growth of murine renal cell carcinoma in vivo

1999 • 15 citations

Overexpression of Fas Ligand Does Not Confer Immune Privilege to a Pancreatic β Tumor Cell Line (βTC-3)

1999 • 15 citations