How do cytotoxic lymphocytes kill their targets?

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

1998 • 3,169 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.

1995 • 2,142 citations

A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

1997 • 2,054 citations

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

1997 • 1,848 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

1994 • 1,549 citations

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

1994 • 1,073 citations

A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain

1995 • 1,007 citations

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1996 • 980 citations

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

1994 • 844 citations

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity.

1993 • 801 citations

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

1996 • 731 citations

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B

1995 • 720 citations

Mechanism of Lymphocyte-Mediated Cytotoxicity

1985 • 602 citations

CPP32/Apopain Is a Key Interleukin 1β Converting Enzyme-like Protease Involved in Fas-mediated Apoptosis

1996 • 480 citations

Immune function in mice lacking the perforin gene.

1994 • 474 citations

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions.

1992 • 447 citations

Long-range disruption of gene expression by a selectable marker cassette

1996 • 377 citations

New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

1996 • 368 citations

FLICE Induced Apoptosis in a Cell-free System

1997 • 343 citations

Granzyme B Directly and Efficiently Cleaves Several Downstream Caspase Substrates: Implications for CTL-Induced Apoptosis

1998 • 316 citations

Cytotoxic T cells deficient in both functional fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft-versus-host disease.

1996 • 310 citations

Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes

1994 • 307 citations

ICE-LAP6, a Novel Member of the ICE/Ced-3 Gene Family, Is Activated by the Cytotoxic T Cell Protease Granzyme B

1996 • 304 citations

The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism.

1996 • 279 citations

Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins

1991 • 255 citations

Target Cell Lysis by CTL Granule Exocytosis Is Independent of ICE/Ced-3 Family Proteases

1997 • 237 citations

Granzyme B (GraB) Autonomously Crosses the Cell Membrane and Perforin Initiates Apoptosis and GraB Nuclear Localization

1997 • 237 citations

A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity.

1994 • 224 citations

Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells.

1995 • 216 citations

Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation.

1997 • 212 citations

In Vitro– and Ex Vivo–derived Cytolytic Leukocytes from Granzyme A × B Double Knockout Mice Are Defective in Granule-mediated Apoptosis but not Lysis of Target Cells

1997 • 192 citations

Granzyme A-deficient mice retain potent cell-mediated cytotoxicity.

1995 • 186 citations

Granule-mediated Killing: Pathways for Granzyme B–initiated Apoptosis

1997 • 178 citations

Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B.

1996 • 175 citations

Reorientation and fusion of cytotoxic T lymphocyte granules after interaction with target cells as determined by high resolution cinemicrography.

1986 • 166 citations

Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin.

1995 • 149 citations

Cleavage of CPP32 by Granzyme B Represents a Critical Role for Granzyme B in the Induction of Target Cell DNA Fragmentation

1996 • 148 citations

Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases

1998 • 144 citations

Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia.

1996 • 139 citations

The role of granzyme B in murine models of acute graft-versus-host disease and graft rejection

1996 • 138 citations

Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them

1997 • 108 citations

Nuclear Transport of Granzyme B (Fragmentin-2)

1996 • 104 citations

Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3

1996 • 101 citations

Processing and Activation of CMH-1 by Granzyme B

1996 • 65 citations

Production of Fully Active Recombinant Murine Granzyme B in Yeast

1998 • 59 citations

Residual Cytotoxicity and Granzyme K Expression in Granzyme A-deficient Cytotoxic Lymphocytes

1997 • 58 citations

Protein sorting and secretion during CTL killing

1997 • 42 citations

Expression and Purification of Enzymatically Active Recombinant Granzyme B in a Baculovirus System

1998 • 41 citations

Mechanisms Responsible for Granzyme B–Independent Cytotoxicity

1997 • 25 citations