A Model for CD8+ CTL Tumor Immunosurveillance and Regulation of Tumor Escape by CD4 T Cells Through an Effect on Quality of CTL

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma

1991 • 3,493 citations

Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells

1996 • 1,908 citations

Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma

1998 • 1,826 citations

Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape

1996 • 1,281 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

IL-4 directs the development of Th2-like helper effectors.

1990 • 1,261 citations

Disruption of the murine IL-4 gene blocks Th2 cytokine responses

1993 • 1,197 citations

A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.

1994 • 934 citations

Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection.

1994 • 921 citations

Lymphocyte apoptosis induced by CD95 (APO–1/Fas) ligand–expressing tumor cells — A mechanism of immune evasion?

1996 • 917 citations

The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand.

1996 • 894 citations

Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines.

1996 • 849 citations

Identification of a Peptide Recognized by Five Melanoma-Specific Human Cytotoxic T Cell Lines

1994 • 841 citations

Vaccinia virus expression vector: coexpression of beta-galactosidase provides visual screening of recombinant virus plaques.

1985 • 789 citations

Colorectal carcinoma-specific antigen: detection by means of monoclonal antibodies.

1979 • 638 citations

A highly immunogenic region of a human polymorphic epithelial mucin expressed by carcinomas is made up of tandem repeats.

1988 • 571 citations

A recombinant vaccinia virus encoding human papillomavirus types 16 and 18, E6 and E7 proteins as immunotherapy for cervical cancer

1996 • 538 citations

Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization

1997 • 526 citations

Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-kappa B activation in hemopoietic progenitor cells.

1998 • 524 citations

Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy.

1996 • 520 citations

Natural history of HLA expression during tumour development

1993 • 448 citations

Vascular Endothelial Growth Factor Affects Dendritic Cell Maturation Through the Inhibition of Nuclear Factor-κB Activation in Hemopoietic Progenitor Cells

1998 • 440 citations

An immunodominant epitope of the human immunodeficiency virus envelope glycoprotein gp160 recognized by class I major histocompatibility complex molecule-restricted murine cytotoxic T lymphocytes.

1988 • 417 citations

Prolongation of Survival in Metastatic Melanoma After Active Specific Immunotherapy With a New Polyvalent Melanoma Vaccine

1992 • 410 citations

Fas ligand expression by astrocytoma in vivo: maintaining immune privilege in the brain?

1997 • 403 citations

Cytotoxic T-lymphocytes derived from patients with breast adenocarcinoma recognize an epitope present on the protein core of a mucin molecule preferentially expressed by malignant cells.

1991 • 353 citations

IL-10 production in cutaneous basal and squamous cell carcinomas. A mechanism for evading the local T cell immune response.

1995 • 326 citations

TGF-beta contributes to the shift toward Th2-type responses through direct and IL-10-mediated pathways in tumor-bearing mice.

1996 • 274 citations

IL-4-deficient Balb/c mice resist infection with Leishmania major.

1996 • 273 citations

Revisiting and revising suppressor T cells

1992 • 256 citations

Escape of mouse mastocytoma P815 after nearly complete rejection is due to antigen-loss variants rather than immunosuppression.

1983 • 251 citations

Dendritic Cells in Antitumor Immune Responses

1996 • 219 citations

Reversal of tumor-induced immunosuppression: a new approach to cancer therapy.

1997 • 219 citations

Local expression of antiinflammatory cytokines in cancer.

1993 • 198 citations

Disregulation in TH1 and TH2 subsets of CD4 + T cells in peripheral blood of colorectal cancer patients and involvement in cancer establishment and progression

1996 • 194 citations

IL-12 induces T helper 1-directed antitumor response.

1997 • 189 citations

Reversal of Tumor-Induced Immunosuppression: A New Approach to Cancer Therapy

1997 • 182 citations

A Single Amino Acid Interchange Yields Reciprocal CTL Specificities for HIV-1 gp160

1989 • 181 citations

Helper-cytotoxic T lymphocyte (CTL) determinant linkage required for priming of anti-HIV CD8+ CTL in vivo with peptide vaccine constructs.

1994 • 181 citations

Immunity to Oncogenic Proteins

1995 • 180 citations

Removal of cryptic poxvirus transcription termination signals from the human immunodeficiency virus type 1 envelope gene enhances expression and immunogenicity of a recombinant vaccinia virus

1990 • 172 citations

A Pathogenic Role of Th2 Cells and Their Cytokine Products on the Pulmonary Metastasis of Murine B16 Melanoma

1998 • 166 citations

Cytotoxic CD4+ and CD8+ T lymphocytes, generated by mutant p21-ras (12VAL) peptide vaccination of a patient, recognize 12VAL-dependent nested epitopes present within the vaccine peptide and kill autologous tumour cells carrying this mutation

1997 • 163 citations

Gene-Modified Tumor Vaccine with Therapeutic Potential Shifts Tumor-Specific T Cell Response from a Type 2 to a Type 1 Cytokine Profile

1998 • 154 citations

Interleukin 2 production in vitro by peripheral lymphocytes in response to human papillomavirus-derived peptides: correlation with cervical pathology.

1996 • 153 citations

Induction of CD8⁺ cytotoxic T lymphocytes by immunization with syngeneic irradiated HIV-1 envelope derived peptide-pulsed dendritic cells

1993 • 138 citations

Mechanisms of syngeneic tumor rejection. Susceptibility of host-selected progressor variants to various immunological effector cells.

1982 • 135 citations

CD4 T cells inhibit in vivo the CD8‐mediated immune response against murine colon carcinoma cells transduced with interleukin‐12 genes

1995 • 125 citations

Schistosoma mansoni in IL-4-deficient mice

1996 • 120 citations

The prototypic Th2 autoimmunity induced by mercury is dependent on IFN-gamma and not Th1/Th2 imbalance.

1998 • 117 citations

IL-2 enhances the function of recombinant poxvirus-based vaccines in the treatment of established pulmonary metastases.

1995 • 117 citations

Effect of the expression of transforming growth factor-β2 in primary human glioblastomas on immunosuppression and loss of immune surveillance

1992 • 109 citations

Active specific immunotherapy with Newcastle-diseasevirus-modified autologous tumor cells following resection of liver metastases in colorectal cancer

1992 • 107 citations

The Prototypic Th2 Autoimmunity Induced by Mercury Is Dependent on IFN-γ and Not Th1/Th2 Imbalance

1998 • 105 citations

Structural requirements for class I MHC molecule-mediated antigen presentation and cytotoxic T cell recognition of an immunodominant determinant of the human immunodeficiency virus envelope protein.

1989 • 102 citations

Selective loss of HLA-A or HLA-B antigen expression in colon carcinoma.

1989 • 101 citations

Renal cell carcinoma treated by vaccines for active specific immunotherapy: Correlation of survival with skin testing by autologous tumor cells

1990 • 98 citations

Broad recognition of cytotoxic T cell epitopes from the HIV-1 envelope protein with multiple class I histocompatibility molecules.

1992 • 97 citations

Major histocompatibility complex class I and unique antigen expression by murine tumors that escaped from CD8+ T-cell-dependent surveillance.

1990 • 91 citations

Human Tumor Antigens Are Ready to Fly

1996 • 85 citations

Molecular analysis of the same HIV peptide functionally binding to both a class I and a class II MHC molecule.

1995 • 85 citations

Expression of HLA class I molecules and the transporter associated with antigen processing in hepatocellular carcinoma

1996 • 80 citations

Vaccinia Virus Expression Vector: Coexpression of β-Galactosidase Provides Visual Screening of Recombinant Virus Plaques

1985 • 76 citations

Construction of an HIV-1 peptide vaccine containing a multideterminant helper peptide linked to a V3 loop peptide 18 inducing strong neutralizing antibody responses in mice of multiple MHC haplotypes after two immunizations.

1993 • 69 citations

Selective loss of beta 2-microglobulin mRNA in human colon carcinoma.

1989 • 56 citations

Candidate HIV Type 1 Multideterminant Cluster Peptide-P18MN Vaccine Constructs Elicit Type 1 Helper T Cells, Cytotoxic T Cells, and Neutralizing Antibody, All Using the Same Adjuvant Immunization

1996 • 50 citations

Prostaglandin E2 Down-Regulates the Expression of HLA-DR Antigen in Human Colon Adenocarcinoma Cell Lines

1995 • 35 citations

Differential growth factor production, secretion, and response by high and low metastatic variants of B16BL6 melanoma.

1993 • 33 citations

Loss of Human Leukocyte Antigen Expression on Colorectal Tumor Cell Lines

1993 • 31 citations

Synergistic effects of co‐expression of the Th1 cytokines il‐2 and IFNγ on generation of murine tumor‐reactive cytotoxic cells

1995 • 27 citations

Preferential V beta usage by cytotoxic T cells cross-reactive between two epitopes of HIV-1 gp160 and degenerate in class I MHC restriction.

1993 • 26 citations

Elimination of CD4+ T cells in mice bearing an advanced sarcoma augments the antitumor action of interleukin-2

1994 • 26 citations

CD4-POSITIVE AND B LYMPHOCYTES IN TRANSPLANTATION IMMUNITY

1993 • 22 citations

An analysis of autologous T‐cell anti‐tumour responses in colon‐carcinoma patients following active specific immunization (ASI)

1992 • 22 citations

Loss of HLA Heavy Chain and β2‐Microglobulin in HLA Negative Tumours

1991 • 17 citations

Novel approaches to peptide and engineered protein vaccines for HIV using defined epitopes: advances in 1994-1995.

1995 • 17 citations