Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

A Theory of Self-Nonself Discrimination

1970 • 1,700 citations

CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

VLA Proteins in the Integrin Family: Structures, Functions, and Their Role on Leukocytes

1990 • 1,592 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

The Role of the CD28 Receptor During T Cell Responses to Antigen

1993 • 1,320 citations

Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy

1992 • 1,290 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

Tumor Antigens Recognized by T Lymphocytes

1994 • 1,238 citations

A new member of the immunoglobulin superfamily—CTLA-4

1987 • 1,214 citations

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg

1992 • 1,156 citations

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.

1991 • 1,132 citations

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

1992 • 1,076 citations

The Biochemistry and Cell Biology of Antigen Processing and Presentation

1993 • 1,022 citations

The T Lymphocyte in Experimental Allergic Encephalomyelitis

1990 • 1,005 citations

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 • 910 citations

B70 antigen is a second ligand for CTLA-4 and CD28

1993 • 907 citations

Bone Marrow Transplantation for Chronic Myelogenous Leukemia in Chronic Phase

1988 • 887 citations

Analysis of 462 Transplantations from Unrelated Donors Facilitated by the National Marrow Donor Program

1993 • 873 citations

IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression.

1993 • 862 citations

Marrow Transplantation from Related Donors Other Than HLA-Identical Siblings

1985 • 844 citations

Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule

1992 • 820 citations

Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system.

1987 • 802 citations

The LFA-1 ligand ICAM-1 provides an important costimulatory signal for T cell receptor-mediated activation of resting T cells.

1990 • 799 citations

T-cell depletion of HLA-identical transplants in leukemia

1991 • 771 citations

Expression of human B cell-associated antigens on leukemias and lymphomas: a model of human B cell differentiation

1984 • 714 citations

Lymphocyte interactions with endothelial cells

1992 • 689 citations

Role of the CD28 receptor in T-cell activation

1990 • 684 citations

Cyclosporin A, FK-506, and Rapamycin: Pharmacologic Probes of Lymphocyte Signal Transduction

1992 • 675 citations

CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines.

1989 • 662 citations

Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

1991 • 660 citations

Adoptive T Cell Therapy of Tumors: Mechanisms Operative in the Recognition and Elimination of Tumor Cells

1991 • 619 citations

Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes.

1992 • 592 citations

Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation.

1993 • 569 citations

CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells.

1991 • 562 citations

T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo.

1992 • 558 citations

Expression of myeloid differentiation antigens on normal and malignant myeloid cells.

1981 • 556 citations

Induction of Immune Responses in Patients with B-Cell Lymphoma against the Surface-Immunoglobulin Idiotype Expressed by Their Tumors

1992 • 551 citations

The Leukocyte Integrins

1989 • 542 citations

The T Cell Receptor as a Multicomponent Signalling Machine: CD4/CD8 Coreceptors and CD45 in T Cell Activation

1992 • 539 citations

T-Cell Proliferation Involving the CD28 Pathway Is Associated witH Cyclosporine-Resistant Interleukin 2 Gene Expression

1987 • 522 citations

Identification of an Alternative CTLA-4 Ligand Costimulatory for T Cell Activation

1993 • 517 citations

Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion.

1993 • 502 citations

Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1.

1993 • 494 citations

B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells.

1989 • 487 citations

Tumor immunogenicity determines the effect of B7 costimulation on T cell-mediated tumor immunity.

1994 • 482 citations

B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2.

1991 • 445 citations

A molecular model of MHC class-I-restricted antigen processing

1992 • 438 citations

Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes.

1992 • 437 citations

CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location.

1991 • 422 citations

T Cell Selection in the Thymus

1988 • 405 citations

Differential costimulatory effects of adhesion molecules B7, ICAM-1, LFA-3, and VCAM-1 on resting and antigen-primed CD4+ T lymphocytes.

1992 • 395 citations

Cell Biology of Antigen Processing and Presentation to Major Histocompatibility Complex Class I Molecule-Restricted T Lymphocytes

1992 • 373 citations

Uncovering of Functional Alternative CTLA-4 Counter-Receptor in B7-Deficient Mice

1993 • 369 citations

Impact of T-cell depletion on outcome of allogeneic bone-marrow transplantation for standardrisk leukaemias.

1987 • 358 citations

Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production.

1993 • 357 citations

Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7.

1991 • 349 citations

The Cell Biology of Antigen Processing and Presentation

1991 • 349 citations

Effect of HLA incompatibility on graft-versus-host disease, relapse, and survival after marrow transplantation for patients with leukemia or lymphoma

1990 • 346 citations

CD28 interaction with B7 costimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes.

1992 • 342 citations

Reversal of in vitro T cell clonal anergy by IL-2 stimulation

1992 • 339 citations

The CD28 ligand B7/BB1 provides costimulatory signal for alloactivation of CD4+ T cells.

1991 • 335 citations

CTLA4 mediates antigen-specific apoptosis of human T cells.

1995 • 331 citations

Monoclonal antibodies identifying a novel T-Cell antigen and Ia antigens of human lymphocytes

1980 • 326 citations

Selective induction of B7/BB-1 on interferon-γ stimulated monocytes: A potential mechanism for amplification of T cell activation through the CD28 pathway

1991 • 325 citations

Costimulation of T cells for tumor immunity

1993 • 324 citations

Characterization of CTLA-4 structure and expression on human T cells.

1993 • 319 citations

IMPACT OF T-CELL DEPLETION ON OUTCOME OF ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR STANDARD-RISK LEUKAEMIAS

1987 • 314 citations

Molecular Components of T-Cell Recognition

1992 • 304 citations

The costimulatory function of antigen-presenting cells

1990 • 304 citations

Molecular Events Mediating T Cell Activation

1990 • 303 citations

Interactions between Immunogenic Peptides and MHC Proteins

1991 • 303 citations

B lymphoblast antigen (BB-1) expressed on Epstein-Barr virus-activated B cell blasts, B lymphoblastoid cell lines, and Burkitt's lymphomas.

1982 • 297 citations

T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif.

1994 • 291 citations

Human T cell activation. II. A new activation pathway used by a major T cell population via a disulfide-bonded dimer of a 44 kilodalton polypeptide (9.3 antigen).

1985 • 285 citations

Exogenous expression of mouse interferon gamma cDNA in mouse neuroblastoma C1300 cells results in reduced tumorigenicity by augmented anti-tumor immunity.

1989 • 284 citations

CD28-B7 interactions allow the induction of CD8+ cytotoxic T lymphocytes in the absence of exogenous help.

1993 • 274 citations

Constitutive expression of B7 restores immunogenicity of tumor cells expressing truncated major histocompatibility complex class II molecules.

1993 • 274 citations

Successful Allogeneic Transplantation of T-Cell–Depleted Bone Marrow from Closely HLA-Matched Unrelated Donors

1990 • 267 citations

Expression and functional significance of an additional ligand for CTLA-4.

1993 • 262 citations

Cell adhesion in the immune system

1993 • 262 citations

Allogeneic non-T spleen cells restore the responsiveness of normal T cell clones stimulated with antigen and chemically modified antigen-presenting cells.

1988 • 260 citations

Marrow transplantation from unrelated donors for treatment of hematologic malignancies: effect of mismatching for one HLA locus

1993 • 234 citations

The two-signal model of lymphocyte activation twenty-one years later

1992 • 233 citations

Peripheral T Cell Tolerance

1992 • 223 citations

Antibodies to Tp67 and Tp44 augment and sustain proliferative responses of activated T cells.

1985 • 218 citations

B7, a B-cell-restricted antigen that identifies preactivated B cells.

1987 • 211 citations

Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation.

1993 • 207 citations

B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance.

1993 • 205 citations

The role of cell division in the induction of clonal anergy

1992 • 203 citations

The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65.

1993 • 201 citations

Identifying Strategies for Immune Intervention

1993 • 194 citations

Unrelated donor marrow transplantation therapy for chronic myelogenous leukemia: initial experience of the National Marrow Donor Program

1993 • 193 citations

A 44 kilodalton cell surface homodimer regulates interleukin 2 production by activated human T lymphocytes.

1986 • 191 citations

Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells.

1994 • 183 citations

The role of the T cell costimulator B7-1 in autoimmunity and the induction and maintenance of tolerance to peripheral antigen

1994 • 181 citations

Two-step TCRζ/CD3-CD4 and CD28 signaling in T cells: SH2/SH3 domains, protein-tyrosine and lipid kinases

1994 • 176 citations

CD28 is an inducible T cell surface antigen that transduces a proliferative signal in CD3+ mature thymocytes.

1990 • 173 citations

CD28 ligation in T-cell activation: evidence for two signal transduction pathways

1990 • 173 citations

Antigen presentation: structural themes and functional variations

1991 • 171 citations

The Development of Functionally Responsive T Cells

1992 • 169 citations

Expression and function of B7 on human epidermal Langerhans cells.

1993 • 166 citations

Control of the Immune Response at the Level of Antigen-Presenting Cells: A Comparison of the Function of Dendritic Cells and B Lymphocytes

1989 • 163 citations

T-cell Clonal Anergy

1989 • 163 citations

Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness.

1994 • 163 citations

Accessory Cell Signals Involved in T‐Cell Activation

1990 • 160 citations

Effective Tumor Vaccine Generated by Fusion of Hepatoma Cells with Activated B Cells

1994 • 154 citations

CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production.

1992 • 153 citations

Signal transduction events leading to T-cell lymphokine gene expression

1993 • 151 citations

Alloantigen-specific cytotoxic and suppressor T lymphocytes are derived from phenotypically distinct precursors.

1983 • 151 citations

Antithoracic duct lymphocyte globulin therapy of severe aplastic anemia

1983 • 144 citations

Transcriptional Regulation of T Cell Receptor Genes

1993 • 142 citations

The murine homologue of the T lymphocyte antigen CD28. Molecular cloning and cell surface expression.

1990 • 141 citations

Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex.

1992 • 138 citations

Mechanisms of Transplantation Tolerance

1994 • 135 citations

Selective depletion of bone marrow T lymphocytes with anti-CD5 monoclonal antibodies: effective prophylaxis for graft-versus-host disease in patients with hematologic malignancies

1991 • 133 citations

Signals involved in T cell activation. T cell proliferation induced through the synergistic action of anti‐CD28 and anti‐CD2 monoclonal antibodies

1988 • 128 citations

Requirements for CD28-dependent T cell-mediated cytotoxicity.

1993 • 125 citations

The CD28 ligand, B7, enhances IL-2 production by providing a costimulatory signal to T cells.

1992 • 125 citations

Perspectives on the Role of Mhc Antigens in Normal and Malignant Cell Development

1989 • 124 citations

Immunologic Interactions of T Lymphocytes with Vascular Endothelium

1991 • 123 citations

Antigen‐Presenting Function of B Lymphocytes

1988 • 121 citations

CD2 is involved in maintenance and reversal of human alloantigen-specific clonal anergy.

1994 • 119 citations

B7/BB1, the ligand for CD28, is expressed on repeatedly activated human T cells in vitro

1993 • 117 citations

Evidence for the involvement of three distinct signals in the induction of IL-2 gene expression in human T lymphocytes.

1989 • 117 citations

Regulation of T-cell lymphokine gene transcription by the accessory molecule CD28.

1992 • 115 citations

Infectious Complications in Adults with Bone Marrow Transplantation and T-Cell Depletion of Donor Marrow

1986 • 112 citations

Role of interaction of CD2 molecules with lymphocyte function-associated antigen 3 in T-cell recognition of nominal antigen.

1990 • 109 citations

Lymphokines and cytokines as cancer treatment.Immunotherapy realized

1990 • 106 citations

CD28 and T cell antigen receptor signal transduction coordinately regulate interleukin 2 gene expression in response to superantigen stimulation.

1992 • 103 citations

Discordant expression of CD28 ligands, BB-1, and B7 on keratinocytes in vitro and psoriatic cells in vivo.

1993 • 103 citations

In vivo expression of the B7 costimulatory molecule by subsets of antigen-presenting cells and the malignant cells of Hodgkin's disease

1994 • 102 citations

Signals arising from antigen-presenting cells

1991 • 100 citations

Multicenter randomized study comparing cyclosporine-A alone and antithymocyte globulin with prednisone for treatment of severe aplastic anemia

1992 • 98 citations

Remote T cell co‐stimulation via LFA‐1/ICAM‐1 and CD2/LFA‐3: Demonstration with immobilized ligand/mAb and implication in monocyte‐mediated co‐stimulation

1991 • 94 citations

A major costimulatory molecule on antigen-presenting cells, CTLA4 ligand A, is distinct from B7.

1993 • 91 citations

T‐Lymphocyte Activation: The Biology and Function of CD2 and CD4

1989 • 87 citations

The B7 adhesion molecule is expressed on activated human T cells: Functional involvement in T‐T cell interactions

1993 • 85 citations

Interferon-alpha restores the deficient expression of the cytoadhesion molecule lymphocyte function antigen-3 by chronic myelogenous leukemia progenitor cells.

1991 • 85 citations

A 45‐kDa human T‐cell membrane glycoprotein functions in the regulation of cell proliferative responses

1984 • 84 citations

Murine B7 antigen provides a sufficient costimulatory signal for antigen-specific and MHC-restricted T cell activation.

1992 • 83 citations

The effect of the immunosuppressant FK‐506 on alternate pathways of T cell activation

1991 • 82 citations

Human CD28 and CTLA-4 Ig superfamily genes are located on chromosome 2 at bands q33?q34

1990 • 81 citations

Activation-dependent phosphorylation of the T-lymphocyte surface receptor CD28 and associated proteins.

1994 • 81 citations

Tp44 molecules involved in antigen-independent T cell activation are expressed on human plasma cells.

1987 • 80 citations

Human intrathymic T cell differentiation.

1990 • 78 citations

Differential regulatory effects of intercellular adhesion molecule-1 on costimulation by the CD28 counter-receptor B7.

1992 • 78 citations

How MHC class II molecules work: peptide-dependent completion of protein folding

1992 • 75 citations

Tumor immunity as autoimmunity: tumor antigens include normal self proteins which stimulate anergic peripheral T cells

1993 • 74 citations

The Endothelial Cell as a Regulator of T‐Cell Function

1990 • 73 citations

Therapy of lymphoma directed at idiotypes.

1990 • 73 citations

Differences in surface phenotype and mechanism of action between alloantigen-specific CD8+ cytotoxic and suppressor T cell clones.

1990 • 73 citations

Bone marrow transplantation for severe aplastic anemia from donors other than HLA identical siblings: a report of the BMT Working Party.

1988 • 67 citations

Mechanisms of Antigen Processing

1988 • 66 citations

Evidence for an additional ligand, distinct from B7, for the CTLA-4 receptor.

1993 • 65 citations

Direct helper T cell‐induced B cell differentiation involves interaction between T cell antigen CD28 and B cell activation antigen B7

1991 • 65 citations

Cell surface markers in hematologic malignancies.

1987 • 64 citations

B7 costimulates proliferation of CD4-8+ T lymphocytes but is not required for the deletion of immature CD4+8+ thymocytes.

1992 • 59 citations

T-cell based cancer immunotherapy: direct or redirected tumor-cell recognition?

1994 • 56 citations

Activation of primary human T-lymphocytes through CD2 plus CD28 adhesion molecules induces long-term nuclear expression of NF-kappa B.

1993 • 56 citations

How do peptides associate with MHC class I molecules?

1991 • 55 citations

IL-1 alpha is produced by T lymphocytes activated via the CD2 plus CD28 pathways.

1991 • 53 citations

Regulation of interleukin 3 gene induction in normal human T cells.

1989 • 52 citations

Successful graft-versus-host disease prevention without graft failure in 32 HLA-identical allogeneic bone marrow transplantations with marrow depleted of T cells by monoclonal antibodies and complement

1987 • 47 citations

Expression of B cell activation antigens on normal and malignant B cells.

1987 • 46 citations

Genes coding for tumor rejection antigens: perspectives for specific immunotherapy.

1994 • 46 citations

Human T cell activation: differential response to anti‐CD28 as compared to anti‐CD3 monoclonal antibodies

1989 • 46 citations

EVIDENCE THAT GENISTEIN, A PROTEIN-TYROSINE KINASE INHIBITOR, INHIBITS CD28 MONOCLONAL-ANTIBODY-STIMULATED HUMAN T CELL PROLIFERATION

1991 • 44 citations

Signalling through CD28 T-cell activation pathway involves an inositol phospholipid-specific phospholipase C activity

1993 • 44 citations

The influence of cyclosporin A on the alternative pathways of human T cell activation in vitro

1989 • 43 citations

The anti-T cell monoclonal antibody 9.3 (Anti-CD28) provides a helper signal and bypasses the need for accessory cells in T Cell activation with immobilized anti-CD3 and mitogens

1989 • 42 citations

Phorbol-12-Myristate-13-Acetate-Treated Human Keratinocytes Express B7-Like Molecules That Serve a Costimulatory Role in T-Cell Activation

1993 • 42 citations

CTLA-4 and CD28: similar proteins, neighbouring genes.

1992 • 40 citations

Evidence for a role of CD28RE as a response element for distinct mitogenic T cell activation signals

1992 • 38 citations

Molecular linkage of the human CTLA4 and CD28 Ig-superfamily genes in yeast artificial chromosomes

1992 • 38 citations

Multiple ways to cellular immune tolerance

1993 • 35 citations

Role of CD2 cross‐linking in cytoplasmic calcium responses and T cell activation

1988 • 35 citations

The gene for B7, a costimulatory signal for T-cell activation, maps to chromosomal region 3q13.3-3q21

1992 • 34 citations

Genomic organization and chromosomal location of the human gene encoding the B-lymphocyte activation antigen B7

1992 • 33 citations

Generation and Characterization of T‐helper Cells by Primary in vitro Sensitization using Langerhans Cells

1990 • 32 citations

Expression and function of adhesion receptors on normal B cells and B cell non-Hodgkin's lymphomas.

1993 • 31 citations

Two distinct mechanisms of interleukin-2 gene expression in human T lymphocytes

1989 • 30 citations

Human suppressor T cell clones lack CD28

1990 • 29 citations

Processing and Presentation of Self Proteins

1988 • 28 citations

In Situ Expression of a B7-Like Adhesion Molecule on Keratinocytes from Human Epidermis

1993 • 25 citations

Interleukin-7 specifically induces the B7/BB1 antigen on human cord blood and peripheral blood T cells and T cell clones

1993 • 24 citations

Regulation of T-cell differentiation by CD2 and CD28 accessory molecules.

1991 • 23 citations

Autoimmune and alloimmune phenomena in patients with aplastic anemia: cytotoxicity against autologous lymphocytes and lymphocytes from HLA identical siblings

1980 • 22 citations

Abnormal t suppressor cell function in juvenile rheumatoid arthritis

1990 • 21 citations

"CD3low" human thymocyte populations can readily be triggered via the CD2 and/or CD28 activation pathways whereas the CD3 pathway remains nonfunctional.

1990 • 19 citations

Inducibility of class II major histocompatibility complex antigens by interferon gamma is associated with reduced tumorigenicity in C3H mouse fibroblasts transformed by v-Ki-ras.

1991 • 16 citations

Contributions of the CD2 and CD28 T lymphocyte activation pathways to the regulation of the expression of the colony-stimulating factor (CSF-1) gene.

1992 • 16 citations

Tolerance and immune regulation

1991 • 10 citations

THE EFFECT OF THE CD28 ACTIVATION PATHWAY ON THE IMMUNOSUPPRESSIVE ACTION OF CYCLOSPORINE

1991 • 9 citations

Activation of peripheral CD8⁺ T lymphocytes via CD28 plus CD2: Evidence for IL‐2 gene transcription mediated by CD28 activation

1991 • 5 citations

Defect of Interleukin-2 Production and T Cell Proliferation in Atopic Patients: Restoring Ability of the CD28-Mediated Activation Pathway

1993 • 5 citations

Induction of Hyporesponsiveness in Human Lymphocytes-T Despite Their Expression of both the Co-receptor CD28 and Its Ligand B7

1993 • 5 citations