Clinical relevance of BCL-2 overexpression in childhood acute lymphoblastic leukemia

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.

1978 • 2,400 citations

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

1995 • 2,114 citations

Involvement of the bcl -2 Gene in Human Follicular Lymphoma

1985 • 1,797 citations

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

1994 • 1,303 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer.

1992 • 1,063 citations

Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

1990 • 926 citations

Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line

1993 • 898 citations

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

1991 • 876 citations

Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity

1995 • 863 citations

Induction of apoptosis by the Bcl-2 homologue Bak

1995 • 738 citations

Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation.

1990 • 622 citations

Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak

1995 • 514 citations

The Bcl-2 Protein: a Prognostic Indicator Strongly Related to p53 Protein in Lymph Node-Negative Breast Cancer Patients

1994 • 461 citations

Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia

1990 • 354 citations

BCL-2: Prevention of Apoptosis as a Mechanism of Drug Resistance

1995 • 323 citations

Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes.

1994 • 305 citations

Bone marrow-derived stromal cells prevent apoptotic cell death in B- lineage acute lymphoblastic leukemia

1992 • 265 citations

Expression of the apoptosis-suppressing protein bcl-2, in neuroblastoma is associated with unfavorable histology and N-myc amplification.

1993 • 262 citations

Bcl-2 maintains B cell memory

1991 • 219 citations

Analysis of immunoglobulin and T cell receptor genes. Part II: Possibilities and limitations in the diagnosis and management of lymphoproliferative diseases and related disorders

1991 • 218 citations

Expression of bcl-2 protein predicts efficacy of adjuvant treatments in operable node-positive breast cancer.

1995 • 203 citations

p53 and bcl-2 expression in high-grade B-cell lymphomas: correlation with survival time

1994 • 188 citations

Oncogenic potential of bcl-2 demonstrated by gene transfer

1988 • 180 citations

E mu-bcl-2 transgene facilitates spontaneous transformation of early pre-B and immunoglobulin-secreting cells but not T cells.

1993 • 162 citations

Adhesion-dependent survival of normal and leukemic human B lymphoblasts on bone marrow stromal cells

1994 • 160 citations

Activation of the Abelson tyrosine kinase activity is associated with suppression of apoptosis in hemopoietic cells.

1993 • 157 citations

Regulation of chemoresistance by the bcl-2 oncoprotein in non-Hodgkin's lymphoma and lymphocytic leukemia cell lines

1994 • 153 citations

Ligation of CD38 suppresses human B lymphopoiesis.

1995 • 150 citations

Determination of linear fluorescence intensities from flow cytometric data accumulated with logarithmic amplifiers

1983 • 124 citations

Bcl‐2 expression is associated with lymph node metastasis in human ductal breast carcinoma

1995 • 99 citations

Bcl-2 protein expression in normal human bone marrow precursors and in acute myelogenous leukemia.

1995 • 98 citations

Interleukin-4 induces programmed cell death (apoptosis) in cases of high-risk acute lymphoblastic leukemia

1994 • 79 citations

Monoclonal antibody-purified factor IX--comparative thrombogenicity to prothrombin complex concentrate.

1991 • 76 citations

Interleukin 7-dependent B lymphocyte precursor cells are ultrasensitive to apoptosis.

1994 • 61 citations

Control of sensitivity to induction of apoptosis in myeloid leukemic cells by differentiation and bcl-2 dependent and independent pathways.

1994 • 53 citations

Stroma-supported immunocytometric assay (SIA): a novel method for testing the sensitivity of acute lymphoblastic leukemia cells to cytotoxic drugs.

1993 • 45 citations