Induction of cytochrome P-450IA1, IA2, IIB1, IIB2 and IIE1 by broccoli in rat liver and colon

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane

1971 • 8,619 citations

Determination of protein: A modification of the lowry method that gives a linear photometric response

1972 • 5,490 citations

Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polycrylamide to nitrocellulose

1984 • 2,553 citations

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

The molecular biology of cytochrome P450s.

1988 • 1,294 citations

Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450

1985 • 1,272 citations

Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA

1984 • 973 citations

The P450 Gene Superfamily: Recommended Nomenclature

1987 • 812 citations

The P450 Superfamily: Updated Listing of All Genes and Recommended Nomenclature for the Chromosomal Loci

1989 • 609 citations

Diet in the Epidemiology of Cancer of the Colon and Rectum<xref ref-type="fn" rid="FN2">2</xref>

1978 • 423 citations

Benzpyrene hydroxylase activity in the gastrointestinal tract.

1962 • 328 citations

Vegetable Consumption and Lung Cancer Risk: A Population-Based Case-Control Study in Hawaii

1989 • 282 citations

Aryl Hydrocarbon Hydroxylase Induction in Rat Tissues by Naturally Occurring Indoles of Cruciferous Plants<xref ref-type="fn" rid="fn2">2</xref>

1975 • 246 citations

Stimulatory effect of brussels sprouts and cabbage on human drug metabolism

1979 • 242 citations

Immunochemical evidence for induction of the alcohol-oxidizing cytochrome P-450 of rabbit liver microsomes by diverse agents: ethanol, imidazole, trichloroethylene, acetone, pyrazole, and isoniazid.

1985 • 215 citations

Inhibition of the carcinogenic action of benzo(a)pyrene by flavones.

1970 • 210 citations

An estimate of the mean daily intake of glucosinolates from cruciferous vegetables in the UK

1984 • 136 citations

Modification by beet and cabbage diets of aflatoxin B1-induced rat plasma α-foetoprotein elevation, hepatic tumorigenesis, and mutagenicity of urine

1982 • 135 citations

Effect of dietary indole-3-carbinol on intestinal and hepatic monooxygenase, glutathione S-transferase and epoxide hydrolase activities in the rat

1984 • 130 citations

Nucleotide sequence of a full-length cDNA coding for 3-methylcholanthrene-induced rat liver cytochrome P-450MC

1984 • 129 citations

Phenobarbital induction of rat liver cytochromes P-450b and P-450e. Quantitation of specific RNAs by hybridization to synthetic oligodeoxyribonucleotide probes.

1985 • 128 citations

Transcriptional and post-transcriptional regulation of the genes encoding cytochromes P-450c and P-450d in vivo and in primary hepatocyte cultures.

1988 • 118 citations

Immunochemical characterization of multiple forms of cytochrome P-450 in rabbit nasal microsomes and evidence for tissue-specific expression of P-450s NMa and NMb.

1990 • 106 citations

Benzpyrene Hydroxylase Activity in the Gastrointestinal Tract

1963 • 105 citations

Differential rates of metabolic activation and detoxication of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by different cytochrome P450 enzymes

1990 • 100 citations

Sex difference in the O-dealkylation activity of 7-hydroxycoumarin O-alkyl derivatives in liver microsomes of rats

1980 • 92 citations

Inhibition of the Carcinogenic Action of 7,12-Dimethylbenz(a)anthracene by Beta-Naphthoflavone

1968 • 86 citations

Induction of cytochrome P450IA1 in rat colon and liver by indole-3-carbinol and 5,6-benzoflavone

1990 • 82 citations

High-performance liquid chromatographic analysis of anticarcinogenic indoles in Brassica oleracea

1987 • 79 citations

Activation of carcinogens and mutagens by rat colon mucosa.

1978 • 69 citations

Expression of cytochrome P450b and P450e genes in small intestinal mucosa of rats following treatment with phenobarbital, polyhalogenated biphenyls, and organochlorine pesticides.

1988 • 66 citations

Effects of dietary broccoli and butylated hydroxyanisole on liver-mediated metabolism of benzo[a]pyrene

1983 • 56 citations

Effects of commonly consumed vegetables on hepatic xenobiotic-metabolizing enzymes in the mouse

1985 • 55 citations

Evidence that the catalytic differences of two structurally homologous forms of cytochrome P-450 relate to their heme environment

1988 • 49 citations

The effects of dietary brussels sprouts and Schizandra chinensis on the xenobiotic-metabolizing enzymes of the rat small intestine

1985 • 47 citations

Carcinogen metabolism in cultured human tissues and cells

1990 • 40 citations

Quantitation of hepatic cytochrome P1-450 mRNA with the use of a cloned DNA probe. Effects of various P-450 inducers in C57BL/6N and DBA/2N mice.

1982 • 37 citations

Effects of dietary cabbage, brussels sprouts, Illicium verum, Schizandra chinensis and alfalfa on the benzo[a]pyrene metabolic system in mouse liver

1983 • 35 citations

Dietary modification of xenobiotic metabolism: contribution of indolylic compounds present in Brassica oleracea

1987 • 29 citations

Role of specific cytochrome P-450 isoenzymes in the regio-selective metabolism of 7, 12-dimethylbenz[a]anthracene in microsomes from rats treated with phenobarbital or Sudan III

1988 • 24 citations

Effect of various chemicals on the metabolism of benzo(a)pyrene by cultured rat colon

1977 • 19 citations

The metabolism of 4,8-DiMeIQx in conventional and germ-free rats

1989 • 18 citations

Effects of Dietary Schizandra chinensis, Brussels sprouts and Illicium verum extracts on carcinogen metabolism systems in mouse liver

1986 • 18 citations

2‐(4′‐Chlorophenyl)benzothiazole is a potent inducer of cytochrome P450IA1 in a human and a mouse cell line

1989 • 9 citations

Distributions and properties of cytochromes P-450 and cytochrome P-450 reductase from rat colon mucosal cells

1987 • 9 citations

An example of P-450 catalytic activities not correlated with corresponding P-450 mRNA concentrations

1986 • 6 citations