Phosphorylation of Human Estrogen Receptor α by Protein Kinase A Regulates Dimerization

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Molecular basis of agonism and antagonism in the oestrogen receptor

1997 • 3,285 citations

The RXR heterodimers and orphan receptors

1995 • 3,168 citations

MOLECULAR MECHANISMS OF ACTION OF STEROID/THYROID RECEPTOR SUPERFAMILY MEMBERS

1994 • 2,875 citations

Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase

1995 • 1,973 citations

Steroid hormone receptors: Many Actors in search of a plot

1995 • 1,854 citations

[11] Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates

1991 • 1,463 citations

Functional domains of the human estrogen receptor

1987 • 1,316 citations

The regulation of transcription by phosphorylation

1992 • 1,316 citations

Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture.

1986 • 1,282 citations

The human estrogen receptor has two independent nonacidic transcriptional activation functions

1989 • 1,066 citations

Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation.

1996 • 992 citations

Cloning, Chromosomal Localization, and Functional Analysis of the Murine Estrogen Receptor β

1997 • 862 citations

Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen.

1990 • 772 citations

The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: How receptors discriminate between their response elements

1993 • 745 citations

The chicken oestrogen receptor sequence: homology with v-erbA and the human oestrogen and glucocorticoid receptors.

1986 • 733 citations

Steroid Hormone Receptors: Interaction with Deoxyribonucleic Acid and Transcription Factors*

1993 • 724 citations

Repression of the Interleukin-6 Promoter by Estrogen Receptor Is Mediated by NF-κB and C/EBPβ

1995 • 692 citations

A versatilein vivoandin vitroeukaryotic expression vector for protein engineering

1988 • 686 citations

Estrogen Receptors α and β Form Heterodimers on DNA

1997 • 681 citations

Mouse Estrogen Receptor β Forms Estrogen Response Element-Binding Heterodimers with Estrogen Receptor α

1997 • 610 citations

HER-2 tyrosine kinase pathway targets estrogen receptor and promotes hormone-independent growth in human breast cancer cells.

1995 • 599 citations

The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function

1988 • 588 citations

Dopaminergic and Ligand-Independent Activation of Steroid Hormone Receptors

1991 • 577 citations

Localisation of the oestradiol-binding and putative DNA-binding domains of the human oestrogen receptor.

1986 • 533 citations

The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling

1993 • 524 citations

The Complete Primary Structure of Human Estrogen Receptor β (hERβ) and Its Heterodimerization with ER αin Vivoandin Vitro

1998 • 510 citations

Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens.

1995 • 502 citations

Activation of the ovalbumin gene by the estrogen receptor involves the Fos-Jun complex

1990 • 486 citations

Antiestrogen ICI 164,384 reduces cellular estrogen receptor content by increasing its turnover.

1992 • 468 citations

Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity.

1994 • 460 citations

Modulation of transcriptional activation by ligand-dependent phosphorylation of the human oestrogen receptor A/B region.

1993 • 451 citations

Stimulation of estrogen receptor-mediated transcription and alteration in the phosphorylation state of the rat uterine estrogen receptor by estrogen, cyclic adenosine monophosphate, and insulin-like growth factor-I.

1993 • 442 citations

The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties.

1989 • 428 citations

Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors

1994 • 404 citations

Inhibition of estrogen receptor-DNA binding by the "pure" antiestrogen ICI 164,384 appears to be mediated by impaired receptor dimerization.

1990 • 400 citations

TRANSCRIPTION ACTIVATION BY ESTROGEN AND PROGESTERONE RECEPTORS

1991 • 372 citations

pp90^rsk1 Regulates Estrogen Receptor-Mediated Transcription through Phosphorylation of Ser-167

1998 • 348 citations

Peptide growth factors elicit estrogen receptor-dependent transcriptional activation of an estrogen-responsive element.

1993 • 322 citations

Stimulation of RARα Activation Function AF-1 through Binding to the General Transcription Factor TFIIH and Phosphorylation by CDK7

1997 • 307 citations

Down-modulation of interleukin-6 gene expression by 17 beta-estradiol in the absence of high affinity DNA binding by the estrogen receptor.

1994 • 307 citations

Identification of two transactlvation domains in the mouse oestrogen receptor

1989 • 303 citations

Human Estrogen Receptor β Binds DNA in a Manner Similar to and Dimerizes with Estrogen Receptor α

1997 • 301 citations

Human vitamin D receptor is selectively phosphorylated by protein kinase C on serine 51, a residue crucial to its trans-activation function.

1991 • 233 citations

Constitutively active human estrogen receptors containing amino acid substitutions for tyrosine 537 in the receptor protein.

1996 • 231 citations

Characterization of the Amino-terminal Transcriptional Activation Function of the Human Estrogen Receptor in Animal and Yeast Cells

1995 • 230 citations

Different Regions in Activation Function-1 of the Human Estrogen Receptor Required for Antiestrogen- and Estradiol-dependent Transcription Activation

1996 • 214 citations

The Mechanism of ICI 164,384 Antiestrogenieity Involves Rapid Loss of Estrogen Receptor in Uterine Tissue

1991 • 201 citations

Synergistic activation of estrogen receptor-mediated transcription by estradiol and protein kinase activators.

1993 • 197 citations

Phosphorylation of the human estrogen receptor on tyrosine 537 in vivo and by src family tyrosine kinases in vitro.

1995 • 183 citations

Serine 167 is the major estradiol-induced phosphorylation site on the human estrogen receptor.

1994 • 165 citations

Two Separate Mechanisms for Ligand-Independent Activation of the Estrogen Receptor

1997 • 153 citations

Protein Phosphatase Types 1 and/or 2A Regulate Nucleocytoplasmic Shuttling of Glucocorticoid Receptors

1991 • 153 citations

POU Transcription Factors Brn-3a and Brn-3b Interact with the Estrogen Receptor and Differentially Regulate Transcriptional Activity via an Estrogen Response Element

1998 • 146 citations

Estradiol and phorbol ester cause phosphorylation of serine 118 in the human estrogen receptor.

1995 • 139 citations

Phosphorylation of Tyrosine 537 on the Human Estrogen Receptor Is Required for Binding to an Estrogen Response Element

1995 • 137 citations

Insulin-like growth factors activate estrogen receptor to control the growth and differentiation of the human neuroblastoma cell line SK-ER3.

1994 • 136 citations

Activation of protein kinase C or cAMP-dependent protein kinase increases phosphorylation of the c-erbA-encoded thyroid hormone receptor and of the v-erbA-encoded protein.

1988 • 136 citations

[27] Properties and use of H-series compounds as protein kinase inhibitors

1991 • 131 citations

Examination of the DNA-binding ability of estrogen receptor in whole cells: implications for hormone-independent transactivation and the actions of antiestrogens.

1992 • 125 citations

Phosphorylation of the retinoic acid receptor-alpha by protein kinase A.

1995 • 122 citations

Ligand-independent activation of the oestrogen receptor by mutation of a conserved tyrosine

1997 • 121 citations

Effect of antagonists on DNA binding properties of the human estrogen receptor in vitro and in vivo.

1995 • 119 citations

Regulating transcription factor activity by phosphorylation

1992 • 115 citations

Phosphorylation of the human vitamin D receptor by protein kinase C. Biochemical and functional evaluation of the serine 51 recognition site

1993 • 115 citations

The unliganded estrogen receptor (ER) transduces growth factor signals

1994 • 113 citations

Phosphorylation of the human estrogen receptor by mitogen-activated protein kinase and casein kinase II: Consequence on DNA binding

1995 • 109 citations

Estradiol-Binding Mechanism and Binding Capacity of the Human Estrogen Receptor Is Regulated by Tyrosine Phosphorylation

1997 • 104 citations

EM-800, a Novel Antiestrogen, Acts as a Pure Antagonist of the Transcriptional Functions of Estrogen Receptors α and β*

1998 • 100 citations

Phosphorylation of steroid receptors

1989 • 100 citations

Antiestrogen can establish nonproductive receptor complexes and alter chromatin structure at target enhancers.

1991 • 99 citations

Phosphorylation of Human Progesterone Receptor by Cyclin-Dependent Kinase 2 on Three Sites That Are Authentic Basal Phosphorylation SitesIn Vivo

1997 • 94 citations

Properties of a purified estradiol-dependent calf uterus tyrosine kinase

1993 • 89 citations

New eukaryotic transcriptional repressers

1993 • 89 citations

Tissue-specific and steroid-dependent interaction of transcription factors with the oestrogen-inducible apoVLDL II promoter in vivo.

1988 • 86 citations

Direct study of DNA-protein interactions in repressed and active chromatin in living cells.

1996 • 85 citations

Cross-coupling between insulin and estrogen receptor in human neuroblastoma cells.

1996 • 84 citations

Phosphorylation of the v-erbA protein is required for its function as an oncogene.

1990 • 83 citations

Selectivity of Cell Cycle Regulation of Glucocorticoid Receptor Function

1995 • 82 citations

Production and Characterization of Monoclonal Antibodies Recognising Defined Regions of the Human Oestrogen Receptor

1993 • 66 citations

In vivo and in vitro phosphorylation of the human estrogen receptor

1995 • 66 citations

Insulin-like growth factors activate estrogen receptor to control the growth and differentiation of the human neuroblastoma cell line SK-ER3

1994 • 65 citations

Activation of transcriptionally inactive human estrogen receptors by cyclic adenosine 3',5'-monophosphate and ligands including antiestrogens.

1994 • 65 citations

Role of Phosphorylation on DNA Binding and Transcriptional Functions of Human Progesterone Receptors

1996 • 64 citations

Cell cycle-dependent glucocorticoid receptor phosphorylation and activity.

1994 • 57 citations

Phosphorylation of Ser211 in the Chicken Progesterone Receptor Modulates its Transcriptional Activity

1996 • 41 citations

In vivofootprinting of the estrogen-inducible vitellogenin II gene from chicken

1988 • 34 citations

Ligand dependence of estrogen receptor induced changes in chromatin structure

1992 • 31 citations