Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation.

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

MOLECULAR MECHANISMS OF ACTION OF STEROID/THYROID RECEPTOR SUPERFAMILY MEMBERS

1994 • 2,875 citations

Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A

1986 • 2,341 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase

1995 • 1,973 citations

Parallel signal processing among mammalian MAPKs

1995 • 1,015 citations

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

1994 • 1,005 citations

Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor.

1987 • 999 citations

Inhibition by cAMP of Ras-Dependent Activation of Raf

1993 • 955 citations

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

1993 • 939 citations

Firefly Luciferase Gene: Structure and Expression in Mammalian Cells

1987 • 924 citations

Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors.

1992 • 829 citations

Reduced levels of hsp90 compromise steroid receptor action in vivo

1990 • 794 citations

Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen.

1990 • 772 citations

The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor.

1993 • 652 citations

Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions.

1994 • 649 citations

HER-2 tyrosine kinase pathway targets estrogen receptor and promotes hormone-independent growth in human breast cancer cells.

1995 • 599 citations

Dopaminergic and Ligand-Independent Activation of Steroid Hormone Receptors

1991 • 577 citations

Steroid receptors and their associated proteins.

1993 • 513 citations

Hormone-mediated repression: a negative glucocorticoid response element from the bovine prolactin gene.

1988 • 485 citations

cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells.

1994 • 473 citations

Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity.

1994 • 460 citations

Modulation of transcriptional activation by ligand-dependent phosphorylation of the human oestrogen receptor A/B region.

1993 • 451 citations

Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases.

1991 • 446 citations

Stimulation of estrogen receptor-mediated transcription and alteration in the phosphorylation state of the rat uterine estrogen receptor by estrogen, cyclic adenosine monophosphate, and insulin-like growth factor-I.

1993 • 442 citations

The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties.

1989 • 428 citations

A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor

1988 • 427 citations

Mutational Analysis of Hsp90 Function: Interactions with a Steroid Receptor and a Protein Kinase

1995 • 425 citations

Evidence That the 90-kDa Heat Shock Protein Is Necessary for the Steroid Binding Conformation of the L Cell Glucocorticoid Receptor

1989 • 394 citations

TRANSCRIPTION ACTIVATION BY ESTROGEN AND PROGESTERONE RECEPTORS

1991 • 372 citations

Regulation of Progesterone Receptor-Mediated Transcription by Phosphorylation

1990 • 365 citations

Agonistic and antagonistic activities of RU486 on the functions of the human progesterone receptor.

1990 • 333 citations

Cyclic AMP activates the mitogen-activated protein kinase cascade in PC12 cells.

1994 • 326 citations

Peptide growth factors elicit estrogen receptor-dependent transcriptional activation of an estrogen-responsive element.

1993 • 322 citations

Mechanism of inhibition of Raf-1 by protein kinase A.

1994 • 311 citations

Functional dissection of the hormone and DNA binding activities of the glucocorticoid receptor.

1987 • 299 citations

Dynamics of heat shock protein 90-progesterone receptor binding and the disactivation loop model for steroid receptor complexes.

1993 • 287 citations

MINIREVIEW: Estrogen Receptor Variants in Clinical Breast Cancer

1991 • 262 citations

Regulatory crosstalk at composite response elements

1991 • 261 citations

Signal transduction by steroid hormones: nuclear localization is differentially regulated in estrogen and glucocorticoid receptors.

1990 • 257 citations

Modulation of the ligand-independent activation of the human estrogen receptor by hormone and antihormone.

1993 • 246 citations

Constitutively active mutants of MAP kinase kinase (MEK1) induce growth factor-relaxation and oncogenicity when expressed in fibroblasts.

1994 • 222 citations

New T47D breast cancer cell lines for the independent study of progesterone B- and A-receptors: only antiprogestin-occupied B-receptors are switched to transcriptional agonists by cAMP.

1994 • 214 citations

The progesterone antagonist RU486 acquires agonist activity upon stimulation of cAMP signaling pathways.

1993 • 208 citations

Isolation of Hsp90 mutants by screening for decreased steroid receptor function.

1993 • 201 citations

Monoclonal antibodies against the rat liver glucocorticoid receptor.

1984 • 188 citations

Phosphorylation of the human estrogen receptor on tyrosine 537 in vivo and by src family tyrosine kinases in vitro.

1995 • 183 citations

Antagonist-occupied human progesterone receptors bound to DNA are functionally switched to transcriptional agonists by cAMP

1993 • 181 citations

Serine 167 is the major estradiol-induced phosphorylation site on the human estrogen receptor.

1994 • 165 citations

Estradiol and phorbol ester cause phosphorylation of serine 118 in the human estrogen receptor.

1995 • 139 citations

Two dominant inhibitory mutants of p21ras interfere with insulin-induced gene expression.

1991 • 138 citations

Insulin-like growth factors activate estrogen receptor to control the growth and differentiation of the human neuroblastoma cell line SK-ER3.

1994 • 136 citations

Specific mutations in the estrogen receptor change the properties of antiestrogens to full agonists.

1995 • 127 citations

In vivo functional protein-protein interaction: nuclear targeted hsp90 shifts cytoplasmic steroid receptor mutants into the nucleus.

1994 • 125 citations

Interaction of hsp90 with steroid receptors: organizing some diverse observations and presenting the newest concepts

1990 • 124 citations

Mechanisms of tamoxifen resistance

1994 • 123 citations

Alteration in the agonist/antagonist balance of antiestrogens by activation of protein kinase A signaling pathways in breast cancer cells: antiestrogen selectivity and promoter dependence.

1994 • 122 citations

Estrogen receptor mutations in breast cancer

1993 • 119 citations

The unliganded estrogen receptor (ER) transduces growth factor signals

1994 • 113 citations

An Alternative Ligand-Independent Pathway for Activation of Steroid Receptors

1995 • 111 citations

New insights into activation of the steroid hormone receptor superfamily

1992 • 111 citations

Latent agonist activity of the steroid antagonist, RU486, is unmasked in cells treated with activators of protein kinase A.

1993 • 109 citations

Negative transcriptional regulation by nuclear receptors.

1994 • 106 citations

Mineralocorticosteroid Receptor of the chick intestine

1989 • 94 citations

Activation of the progesterone receptor by the gonadotropin-releasing hormone self-priming signaling pathway.

1994 • 94 citations

Steroid-binding domains for regulating the functions of heterologous proteins in cis

1993 • 77 citations

Multiple signaling pathways activate the chicken progesterone receptor.

1994 • 75 citations

Differential effects on cAMP on the MAP kinase cascade: evidence for a cAMP-insensitive step that can bypass Raf-1.

1995 • 68 citations

Deciphering the MAP kinase pathway

1994 • 66 citations

In vivo and in vitro phosphorylation of the human estrogen receptor

1995 • 66 citations

Activation of transcriptionally inactive human estrogen receptors by cyclic adenosine 3',5'-monophosphate and ligands including antiestrogens.

1994 • 65 citations

Eukaryotic regulatory elements lurking in plasmid DNA: the activator protein-1 site in pUC.

1994 • 64 citations

Subunit structure of the nonactivated human estrogen receptor.

1995 • 64 citations

Modulation of markers associated with tumor aggressiveness in human breast cancer cell lines by N-(4-hydroxyphenyl) retinamide.

1995 • 61 citations

The MEK Kinase Activity of the Catalytic Domain of RAF-1 Is Regulated Independently of Ras Binding in T Cells

1995 • 58 citations

Phosphorylation of c-Raf-1 by Protein Kinase A Interferes with Activation

1994 • 52 citations

When tamoxifen turns bad.

1995 • 35 citations

How do breast cancers become hormone resistant?

1994 • 32 citations

Ligand-regulated Nonspecific Inactivation of Receptor Function: A Versatile Mechanism for Signal Transduction

1988 • 32 citations

Mutational analysis of cysteine residues within the hormone-binding domain of the human estrogen receptor identifies mutants that are defective in both DNA-binding and subcellular distribution.

1994 • 31 citations

Transcription Activation by Nuclear Receptors

1993 • 28 citations

Phosphorylation Sites in Ligand-Induced and Ligand-Independent Activation of the Progesterone Receptor

1994 • 25 citations

Two Dominant Inhibitory Mutants of p21^ras Interfere with Insulin-Induced Gene Expression

1991 • 24 citations

Steroid receptor variants and their potential role in cancer.

1994 • 23 citations