The PD-1–PD-L pathway in immunological tolerance

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

2002 • 4,625 citations

Tolerogenic Dendritic Cells

2003 • 3,131 citations

Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.

1992 • 2,906 citations

Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

2002 • 2,879 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 • 2,746 citations

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

1999 • 2,574 citations

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

1999 • 2,380 citations

THE B7 FAMILY REVISITED

2005 • 2,239 citations

Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice

2001 • 1,761 citations

IgG Fc Receptors

2001 • 1,667 citations

Blockade of B7-H1 improves myeloid dendritic cell–mediated antitumor immunity

2003 • 1,255 citations

SHP-1 and SHP-2 Associate with Immunoreceptor Tyrosine-Based Switch Motif of Programmed Death 1 upon Primary Human T Cell Stimulation, but Only Receptor Ligation Prevents T Cell Activation

2004 • 1,128 citations

Blockade of B7-H1 and PD-1 by Monoclonal Antibodies Potentiates Cancer Therapeutic Immunity

2005 • 972 citations

Expression of Programmed Death 1 Ligands by Murine T Cells and APC

2002 • 908 citations

B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells

2001 • 850 citations

BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1

2003 • 816 citations

PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

2001 • 786 citations

The Programmed Death-1 (PD-1) Pathway Regulates Autoimmune Diabetes in Nonobese Diabetic (NOD) Mice

2003 • 766 citations

Clinical Significance of Programmed Death-1 Ligand-1 and Programmed Death-1 Ligand-2 Expression in Human Esophageal Cancer

2005 • 758 citations

A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans

2002 • 756 citations

PD-L1/B7H-1 Inhibits the Effector Phase of Tumor Rejection by T Cell Receptor (TCR) Transgenic CD8+ T Cells

2004 • 748 citations

Spontaneous Autoimmune Disease in FcγRIIB-Deficient Mice Results from Strain-Specific Epistasis

2000 • 747 citations

Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target

2004 • 742 citations

B7-H1 Expression on Non-Small Cell Lung Cancer Cells and Its Relationship with Tumor-Infiltrating Lymphocytes and Their PD-1 Expression

2004 • 664 citations

PD-1:PD-L inhibitory pathway affects both CD4+ and CD8+ T cells and is overcome by IL-2

2002 • 646 citations

Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice

2003 • 644 citations

Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses

2003 • 594 citations

Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4

2005 • 532 citations

Critical Role of the Programmed Death-1 (PD-1) Pathway in Regulation of Experimental Autoimmune Encephalomyelitis

2003 • 486 citations

B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma.

2003 • 481 citations

PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells

2004 • 476 citations

Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses

1998 • 469 citations

Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance

2005 • 429 citations

Establishment of NOD-Pdcd1^-/-mice as an efficient animal model of type I diabetes

2005 • 409 citations

A critical role for the programmed death ligand 1 in fetomaternal tolerance

2005 • 402 citations

PD-1 Inhibits Antiviral Immunity at the Effector Phase in the Liver

2003 • 373 citations

Expression of the B7 - related molecule B7 - H1 by glioma cells: a potential mechanism of immune paralysis

2003 • 370 citations

Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues

2002 • 269 citations

B7-H1 (Programmed Death-1 Ligand) on Dendritic Cells Is Involved in the Induction and Maintenance of T Cell Anergy

2003 • 263 citations

Association of a putative regulatory polymorphism in the PD‐1 gene with susceptibility to type 1 diabetes

2003 • 227 citations

New regulatory co-receptors: inducible co-stimulator and PD-1

2002 • 227 citations

Fc Receptors and Their Role in Immune Regulation and Autoimmunity

2005 • 226 citations

The Roles of the New Negative T Cell Costimulatory Pathways in Regulating Autoimmunity

2004 • 208 citations

Differential binding properties of B7-H1 and B7-DC to programmed death-1

2003 • 198 citations

B7 Family Molecules Are Favorably Positioned at the Human Maternal-Fetal Interface1

2003 • 191 citations

Maturation requirements for dendritic cells in T cell stimulation leading to tolerance versus immunity

2005 • 187 citations

Schistosoma mansoni Worms Induce Anergy of T Cells via Selective Up-Regulation of Programmed Death Ligand 1 on Macrophages

2004 • 181 citations

Blockade of B7-H1 Suppresses the Development of Chronic Intestinal Inflammation

2003 • 168 citations

Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection

2004 • 160 citations

In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses

2005 • 152 citations

A new haplotype of PDCD1 is associated with rheumatoid arthritis in Hong Kong Chinese

2005 • 142 citations

B7-DC Regulates Asthmatic Response by an IFN-γ-Dependent Mechanism

2004 • 135 citations

Blockade of B7-H1 on Macrophages Suppresses CD4+ T Cell Proliferation by Augmenting IFN-γ-Induced Nitric Oxide Production

2005 • 134 citations

Designer dendritic cells for tolerance induction: guided not misguided missiles

2001 • 132 citations

Blocking Programmed Death-1 Ligand-PD-1 Interactions by Local Gene Therapy Results in Enhancement of Antitumor Effect of Secondary Lymphoid Tissue Chemokine

2004 • 122 citations

Prevention of Experimental Autoimmune Encephalomyelitis by Transfer of Embryonic Stem Cell-Derived Dendritic Cells Expressing Myelin Oligodendrocyte Glycoprotein Peptide along with TRAIL or Programmed Death-1 Ligand

2005 • 119 citations

Association of PDCD1 with susceptibility to systemic lupus erythematosus

2004 • 119 citations

Differential Effects of B and T Lymphocyte Attenuator and Programmed Death-1 on Acceptance of Partially versus Fully MHC-Mismatched Cardiac Allografts

2005 • 116 citations

PD‐L2:PD‐1 involvement in T cell proliferation, cytokine production, and integrin‐mediated adhesion

2005 • 111 citations

Human muscle cells express a B7‐related molecule, B7‐H1, with strong negative immune regulatory potential: a novel mechanism of counterbalancing the immune attack in idiopathic inflammatory myopathies

2003 • 108 citations

Generation and genetic modification of dendritic cells derived from mouse embryonic stem cells

2003 • 96 citations

Human Rhinoviruses Inhibit the Accessory Function of Dendritic Cells by Inducing Sialoadhesin and B7-H1 Expression

2005 • 88 citations

Paradoxical role of programmed death‐1 ligand 2 in Th2 immune responses in vitro and in a mouse asthma model in vivo

2004 • 47 citations

Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b −/− Pdcd1 −/− mice

2005 • 46 citations

Pathogenic roles of cardiac autoantibodies in dilated cardiomyopathy

2005 • 43 citations