The Calcineurin Phosphatase Complex Modulates Immunogenic B Cell Responses

Inducible Gene Targeting in Mice

1995 • 1,897 citations

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

1988 • 1,562 citations

NFAT Signaling

2002 • 1,316 citations

Blimp-1 Is Required for the Formation of Immunoglobulin Secreting Plasma Cells and Pre-Plasma Memory B Cells

2003 • 797 citations

Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5

2004 • 731 citations

B lymphocyte-specific, Cre-mediated mutagenesis in mice

1997 • 696 citations

Transcriptional Mechanisms Underlying Lymphocyte Tolerance

2002 • 658 citations

Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function

1997 • 581 citations

Models of T cell anergy: is there a common molecular mechanism?

1996 • 575 citations

Positive Selection of Natural Autoreactive B Cells

1999 • 574 citations

Survival of Resting Mature B Lymphocytes Depends on BCR Signaling via the Igα/β Heterodimer

2004 • 552 citations

CXCL13 Is Required for B1 Cell Homing, Natural Antibody Production, and Body Cavity Immunity

2002 • 521 citations

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

2004 • 512 citations

Attenuation of Apoptosis Underlies B Lymphocyte Stimulator Enhancement of Humoral Immune Response

2000 • 431 citations

Polygenic Autoimmune Traits: Lyn, CD22, and SHP-1 Are Limiting Elements of a Biochemical Pathway Regulating BCR Signaling and Selection

1998 • 427 citations

NFATc1 and NFATc2 Together Control Both T and B Cell Activation and Differentiation

2001 • 397 citations

Different Nuclear Signals Are Activated by the B Cell Receptor during Positive Versus Negative Signaling

1997 • 383 citations

Regulatory Mechanisms that Determine the Development and Function of Plasma Cells

2003 • 364 citations

The Transcription Factor NF-ATc1 Regulates Lymphocyte Proliferation and Th2 Cytokine Production

1998 • 340 citations

Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells.

1994 • 340 citations

Commitment of B Lymphocytes to a Plasma Cell Fate Is Associated with Blimp-1 Expression In Vivo

2000 • 337 citations

Inhibitory Function of Two NFAT Family Members in Lymphoid Homeostasis and Th2 Development

1998 • 325 citations

Protein kinase Cδ controls self-antigen-induced B-cell tolerance

2002 • 265 citations

Reduced life span of anergic self-reactive B cells in a double-transgenic model.

1994 • 256 citations

Calcineurin B1 Is Essential for Positive but Not Negative Selection during Thymocyte Development

2004 • 216 citations

Cd5 Maintains Tolerance in Anergic B Cells

2000 • 213 citations

How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis

2000 • 212 citations

Rel Induces Interferon Regulatory Factor 4 (IRF-4) Expression in Lymphocytes

2000 • 193 citations

Resistance to CpG DNA–induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling

2003 • 184 citations

Defective T cell development and function incalcineurinAβ-deficient mice

2002 • 182 citations

IκB Kinase Signaling Is Essential for Maintenance of Mature B Cells

2002 • 179 citations

Selective effects of cyclosporin A on functional B cell subsets in the mouse.

1980 • 150 citations

T cell responses in calcineurin A alpha-deficient mice.

1996 • 149 citations

Germinal center reaction

2001 • 140 citations

Monoclonal vs. heterogeneous anti‐H‐8 antibodies in the analysis of the anti‐phosphorylcholine response in BALB/c mice

1981 • 127 citations

Induction of NF-AT in normal B lymphocytes by anti-immunoglobulin or CD40 ligand in conjunction with IL-4

1994 • 125 citations

Cyclosporin-a sensitive induction of NF-AT in murine B cells

1994 • 124 citations

Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling

2003 • 107 citations

CDK Inhibitor p18INK4c Is Required for the Generation of Functional Plasma Cells

2002 • 106 citations

Cell type specificity and activation requirements for NFAT-1 (nuclear factor of activated T-cells) transcriptional activity determined by a new method using transgenic mice to assay transcriptional activity of an individual nuclear factor.

1990 • 101 citations

Active Inhibition of Plasma Cell Development in Resting B Cells by Microphthalmia-associated Transcription Factor

2004 • 92 citations

Normal B-1a cell development requires B cell-intrinsic NFATc1 activity

2003 • 76 citations

Structure and expression of two isoforms of the murine calmodulin-dependent protein phosphatase regulatory subunit (calcineurin B)

1992 • 75 citations

Differential expression of calmodulin-binding proteins in B, T lymphocytes and thymocytes

1987 • 70 citations

Redundant expression but selective utilization of nuclear factor of activated T cells family members.

1997 • 70 citations

Major Histocompatibility Complex Class II Presentation of Cell-associated Antigen Is Mediated by CD8α+ Dendritic Cells In Vivo

2002 • 64 citations

Review: The Role of IRF-4 in B and T Cell Activation and Differentiation

2002 • 60 citations

Cell‐cycle control of plasma cell differentiation and tumorigenesis

2003 • 59 citations

Regulation of IFN Regulatory Factor 4 Expression in Human T Cell Leukemia Virus-I-Transformed T Cells

2002 • 58 citations

BCR targets cyclin D2 via Btk and the p85α subunit of PI3-K to induce cell cycle progression in primary mouse B cells

2003 • 54 citations

Contribution of Lyb 5+ and Lyb 5- B cells to the primary and secondary phosphocholine-specific antibody response.

1983 • 38 citations

Cyclosporine, Tolerance, and Autoimmunity

1993 • 35 citations

B-cell antigen receptor activates transcription factors NFAT (nuclear factor of activated T-cells) and NF-κB (nuclear factor κB) via a mechanism that involves diacylglycerol

2004 • 35 citations

Vav Is Required for Cyclin D2 Induction and Proliferation of Mouse B Lymphocytes Activated via the Antigen Receptor

2001 • 33 citations

Properties of mouse CD40. Ligation of CD40 activates B cells via a Ca⁺⁺‐dependent, FK506‐sensitive pathway

1994 • 26 citations

Self-tolerance in B lymphocytes.

1989 • 14 citations

Cyclosporin A has differential effects on the responses of murine B cells to TI antigens and B-cell mitogens.

1986 • 6 citations