A Role for c-fos/Activator Protein 1 in B Lymphocyte Terminal Differentiation

The c-fos protein interacts with c-JunAP-1 to stimulate transcription of AP-1 responsive genes

1988 • 1,352 citations

The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation

1994 • 1,099 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

D-type cyclin-dependent kinase activity in mammalian cells.

1994 • 1,073 citations

Bone and haematopoietic defects in mice lacking c-fos

1992 • 939 citations

BCL-6 Represses Genes that Function in Lymphocyte Differentiation, Inflammation, and Cell Cycle Control

2000 • 862 citations

The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

1993 • 840 citations

Blimp-1 Is Required for the Formation of Immunoglobulin Secreting Plasma Cells and Pre-Plasma Memory B Cells

2003 • 797 citations

Mice deficient for the CD40 ligand

1994 • 753 citations

Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells

1994 • 752 citations

Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal.

1993 • 622 citations

Common DNA binding site for Fos protein complexesand transcription factor AP-1

1988 • 613 citations

Generation of Memory B Cells and Plasma Cells in Vitro

1995 • 585 citations

BCL-6 protein is expressed in germinal-center B cells

1995 • 582 citations

Long-Term Human B Cell Lines Dependent on Interleukin-4 and antibody to CD40

1991 • 554 citations

c-JUN, JUN B, and JUN D differ in their binding affinities to AP-1 and CRE consensus sequences: effect of FOS proteins.

1991 • 543 citations

The Fos Complex and Fos-Related Antigens Recognize Sequence Elements That Co ntain AP-1 Binding Sites

1988 • 532 citations

fos-associated cellular p39 is related to nuclear transcription factor AP-1

1988 • 508 citations

Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers.

1995 • 481 citations

Inducible production of c-fos antisense RNA inhibits 3T3 cell proliferation.

1986 • 468 citations

The Role of CD40 Ligand in Costimulation and T‐Cell Activation

1996 • 441 citations

Blimp-1-Dependent Repression of Pax-5 Is Required for Differentiation of B Cells to Immunoglobulin M-Secreting Plasma Cells

2002 • 427 citations

Repression of c- myc Transcription by Blimp-1, an Inducer of Terminal B Cell Differentiation

1997 • 412 citations

Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion.

1992 • 409 citations

Disruption of the Bcl6 Gene Results in an Impaired Germinal Center Formation

1997 • 348 citations

Induction of c-fos during myelomonocytic differentiation and macrophage proliferation

1985 • 340 citations

Commitment of B Lymphocytes to a Plasma Cell Fate Is Associated with Blimp-1 Expression In Vivo

2000 • 337 citations

D-Type Cyclin-Dependent Kinase Activity in Mammalian Cells

1994 • 322 citations

BCL-6 gene product, a 92- to 98-kD nuclear phosphoprotein, is highly expressed in germinal center B cells and their neoplastic counterparts

1995 • 284 citations

Human B cell proliferation and Ig secretion induced by recombinant CD40 ligand are modulated by soluble cytokines.

1993 • 276 citations

CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation.

1994 • 245 citations

Memory B Cells without Somatic Hypermutation Are Generated from Bcl6-Deficient B Cells

2002 • 244 citations

Suppression of Signal Transducer and Activator of Transcription 3–Dependent B Lymphocyte Terminal Differentiation by Bcl-6

2000 • 219 citations

Cell division number regulates IgG1 and IgE switching of B cells following stimulation by CD40 ligand and IL-4

1998 • 204 citations

Repression of AP-1 Function: A Mechanism for the Regulation of Blimp-1 Expression and B Lymphocyte Differentiation by the B Cell Lymphoma-6 Protooncogene

2002 • 191 citations

Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice.

1996 • 152 citations

Arrest of B Lymphocyte Terminal Differentiation by CD40 Signaling: Mechanism for Lack of Antibody-Secreting Cells in Germinal Centers

1998 • 144 citations

Recombinant CD40 ligand stimulation of murine B cell growth and differentiation: cooperative effects of cytokines

1993 • 125 citations

The regulation of T cell-dependent antibody formation in vitro by CD40 ligand and IL-2.

1993 • 97 citations

Induction by anti‐CD40 antibody or soluble CD40 ligand and cytokines of IgG, IgA and IgE production by B cells from patients with X‐linked hyper IgM syndrome

1993 • 96 citations

c-fos expression interferes with thymus development in transgenic mice

1988 • 84 citations

Receptor-specific induction of individual AP-1 components in B lymphocytes.

1995 • 72 citations

CD40 ligand‐independent B cell activation revealed by CD40 ligand‐deficient T cell clones: evidence for distinct activation requirements for antibody formation and B cell proliferation

1995 • 66 citations

Differential Involvement of the Transcription Factor Blimp-1 in T Cell-Independent and -Dependent B Cell Differentiation to Plasma Cells

1999 • 56 citations

The differentiation of human memory B cells into specific antibody‐secreting cells is CD40 independent

1996 • 55 citations

Bcl6 Is a Transcriptional Repressor for theIL-18Gene

2003 • 49 citations

CD40 cross-linking inhibits specific antibody production by human B cells

1995 • 41 citations

c-Fos Induces Apoptosis in Germinal Center B Cells

1998 • 40 citations

Analysis of IL-2 gene regulation in c-fos transgenic mice. Evidence for an enhancement of IL-2 expression in splenic T cells stimulated via TCR/CD3 complex.

1994 • 27 citations

Overexpression of c-fos inhibits down-regulation of a cyclin-dependent kinase-2 inhibitor p27Kip1 in splenic B cells activated by surface Ig cross-linking.

1997 • 25 citations

IgG response is impaired in H2-c-fos transgenic mice

1991 • 24 citations

Role of B-lymphocyte-induced Maturation Protein-1 in Terminal Differentiation of B Cells and Other Cell Lineages

1999 • 12 citations

Deregulated c-fos Modulates B Cell Responses to Switch Mediators

1993 • 8 citations