Gene Repression by Pax5 in B Cells Is Essential for Blood Cell Homeostasis and Is Reversed in Plasma Cells

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

1999 • 3,340 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

Plasma cell differentiation requires the transcription factor XBP-1

2001 • 1,256 citations

Identification of Flt3+ Lympho-Myeloid Stem Cells Lacking Erythro-Megakaryocytic Potential

2005 • 1,169 citations

Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

1999 • 1,139 citations

Epigenetic Regulation of Cellular Memory by the Polycomb and Trithorax Group Proteins

2004 • 1,049 citations

Blimp-1 Orchestrates Plasma Cell Differentiation by Extinguishing the Mature B Cell Gene Expression Program

2002 • 1,000 citations

XBP1, Downstream of Blimp-1, Expands the Secretory Apparatus and Other Organelles, and Increases Protein Synthesis in Plasma Cell Differentiation

2004 • 978 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

Control of Inflammation, Cytokine Expression, and Germinal Center Formation by BCL-6

1997 • 921 citations

Stepwise Reprogramming of B Cells into Macrophages

2004 • 919 citations

BCL-6 Represses Genes that Function in Lymphocyte Differentiation, Inflammation, and Cell Cycle Control

2000 • 862 citations

The role of FLT3 in haematopoietic malignancies

2003 • 831 citations

Integrin-associated protein (CD47) and its ligands

2001 • 824 citations

Wnt/Frizzled Activation of Rho Regulates Vertebrate Gastrulation and Requires a Novel Formin Homology Protein Daam1

2001 • 807 citations

Blimp-1 Is Required for the Formation of Immunoglobulin Secreting Plasma Cells and Pre-Plasma Memory B Cells

2003 • 797 citations

Cellular Niches Controlling B Lymphocyte Behavior within Bone Marrow during Development

2004 • 757 citations

Multilineage gene expression precedes commitment in the hemopoietic system.

1997 • 757 citations

Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2

1997 • 671 citations

Roles of Fc receptors in autoimmunity

2002 • 609 citations

Chemokines Trigger Immediate β2 Integrin Affinity and Mobility Changes

2000 • 517 citations

Transcriptional Control of Early B Cell Development

2004 • 479 citations

Myeloid or Lymphoid Promiscuity as a Critical Step in Hematopoietic Lineage Commitment

2002 • 428 citations

Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus.

1997 • 411 citations

Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors

1999 • 386 citations

Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines

2000 • 382 citations

Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis

2002 • 375 citations

Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments

1998 • 314 citations

Reversion of B Cell Commitment upon Loss of Pax5 Expression

2002 • 285 citations

Disruption of Transforming Growth Factor-β Signaling in ELF β-Spectrin-Deficient Mice

2003 • 258 citations

CD28 is required for germinal center formation.

1996 • 251 citations

Pax5/BSAP Maintains the Identity of B Cells in Late B Lymphopoiesis

2001 • 246 citations

Pax5 Promotes B Lymphopoiesis and Blocks T Cell Development by Repressing Notch1

2002 • 239 citations

A new gene involved in X-linked mental retardation identified by analysis of an X;2 balanced translocation

2000 • 236 citations

Vav GEFs are required for β2 integrin-dependent functions of neutrophils

2004 • 220 citations

Dual effects of macrophage inflammatory protein-1α on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone disease

2003 • 214 citations

Hematopoietic stem cells and their niche

2005 • 205 citations

Non–T Cell Activation Linker (NTAL)

2002 • 203 citations

Insulin-like growth factor 2 expressed in a novel fetal liver cell population is a growth factor for hematopoietic stem cells

2003 • 196 citations

Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1.

1996 • 189 citations

Hematopoietic stem cell and progenitor defects in Sca-1/Ly-6A–null mice

2002 • 186 citations

Control of Pre-BCR Signaling by Pax5-Dependent Activation of the BLNK Gene

2002 • 162 citations

T cell responses in calcineurin A alpha-deficient mice.

1996 • 149 citations

A B220+ CD117+ CD19± hematopoietic progenitor with potent lymphoid and myeloid developmental potential

2005 • 148 citations

Requirement for the SLP-76 Adaptor GADS in T Cell Development

2001 • 145 citations

An Interleukin-2 Signal Relieves BSAP (Pax5)-Mediated Repression of the Immunoglobulin J Chain Gene

1996 • 125 citations

Mouse cathepsin K: cDNA cloning and predominant expression of the gene in osteoclasts, and in some hypertrophying chondrocytes during mouse development

1996 • 114 citations

CC Chemokine Ligand 3 (CCL3) Regulates CD8⁺-T-Cell Effector Function and Migration following Viral Infection

2003 • 110 citations

Myeloid lineage switch of Pax5 mutant but not wild-type B cell progenitors by C/EBP and GATA factors

2003 • 92 citations

Polymer IgM assembly and secretion in lymphoid and nonlymphoid cell lines: evidence that J chain is required for pentamer IgM synthesis.

1995 • 79 citations

Epigenetic silencing of the c-fms locus during B-lymphopoiesis occurs in discrete steps and is reversible

2004 • 72 citations

Pax5-Deficient Mice Exhibit Early Onset Osteopenia with Increased Osteoclast Progenitors

2004 • 65 citations

Neuropeptide control of bone marrow neutrophil production is mediated by both direct and indirect effects on CFU‐GM

2000 • 53 citations

Embigin, a Member of the Immunoglobulin Superfamily Expressed in Embryonic Cells, Enhances Cell-Substratum Adhesion

1993 • 51 citations

Leukocyte-specific protein 1 targets the ERK/MAP kinase scaffold protein KSR and MEK1 and ERK2 to the actin cytoskeleton

2004 • 42 citations

gp49B1 suppresses stem cell factor‐induced mast cell activation‐secretion and attendant inflammation in vivo

2003 • 37 citations