Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination

Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

2000 • 3,323 citations

Clonal selection and learning in the antibody system

1996 • 1,710 citations

Germinal Centers

1994 • 1,680 citations

Plasma cell differentiation requires the transcription factor XBP-1

2001 • 1,256 citations

Molecular Diagnosis of Primary Mediastinal B Cell Lymphoma Identifies a Clinically Favorable Subgroup of Diffuse Large B Cell Lymphoma Related to Hodgkin Lymphoma

2003 • 1,080 citations

XBP1, Downstream of Blimp-1, Expands the Secretory Apparatus and Other Organelles, and Increases Protein Synthesis in Plasma Cell Differentiation

2004 • 978 citations

Control of Inflammation, Cytokine Expression, and Germinal Center Formation by BCL-6

1997 • 921 citations

The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma

2003 • 843 citations

The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation

1997 • 815 citations

Blimp-1 Is Required for the Formation of Immunoglobulin Secreting Plasma Cells and Pre-Plasma Memory B Cells

2003 • 797 citations

Widespread recombinase expression using FLPeR (Flipper) mice

2000 • 587 citations

Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function

1997 • 581 citations

Interferon regulatory factors: the next generation

1999 • 550 citations

Plasma Cell Ontogeny Defined by Quantitative Changes in Blimp-1 Expression

2004 • 500 citations

A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells

2000 • 478 citations

Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.

1995 • 451 citations

The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response

1997 • 437 citations

B lymphocytes express and lose syndecan at specific stages of differentiation.

1989 • 422 citations

Transcriptional analysis of the B cell germinal center reaction

2003 • 401 citations

Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma

1997 • 351 citations

Commitment of B Lymphocytes to a Plasma Cell Fate Is Associated with Blimp-1 Expression In Vivo

2000 • 337 citations

Ability of the hydrophobic FGF and basic TAT peptides to promote cellular uptake of recombinant Cre recombinase: A tool for efficient genetic engineering of mammalian genomes

2002 • 335 citations

Antigen-driven B cell differentiation in vivo.

1993 • 308 citations

IRF-4,8 orchestrate the pre-B-to-B transition in lymphocyte development

2003 • 262 citations

Early appearance of germinal center–derived memory B cells and plasma cells in blood after primary immunization

2005 • 254 citations

Molecular cloning ofLSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE)

1995 • 237 citations

The Balance Between Pax5 and Id2 Activities Is the Key to AID Gene Expression

2003 • 225 citations

Germinal centre B cells: antigen specificity and changes in heavy chain class expression

1982 • 220 citations

Tracking germinal center B cells expressing germ-line immunoglobulin γ1 transcripts by conditional gene targeting

2006 • 214 citations

Cell division number regulates IgG1 and IgE switching of B cells following stimulation by CD40 ligand and IL-4

1998 • 204 citations

The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response.

1990 • 200 citations

Evidence from the generation of immunoglobulin G–secreting cells that stochastic mechanisms regulate lymphocyte differentiation

2003 • 199 citations

A Novel Interferon Regulatory Factor Family Transcription Factor, ICSAT/Pip/LSIRF, That Negatively Regulates the Activity of Interferon-Regulated Genes

1996 • 197 citations

AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line

2002 • 185 citations

Tracking CD40 signaling during germinal center development

2004 • 176 citations

Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein

2005 • 175 citations

A hallmark of active class switch recombination: Transcripts directed by I promoters on looped-out circular DNAs

2001 • 169 citations

Nuclear and cytoplasmic AID in extrafollicular and germinal center B cells

2006 • 168 citations

STAT5 regulates the self-renewal capacity and differentiation of human memory B cells and controls Bcl-6 expression

2005 • 161 citations

Kinetics of Establishing the Memory B Cell Population as Revealed by CD38 Expression

1998 • 146 citations

Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells

2005 • 146 citations

Arrest of B Lymphocyte Terminal Differentiation by CD40 Signaling: Mechanism for Lack of Antibody-Secreting Cells in Germinal Centers

1998 • 144 citations

Lineage-Specific Modulation of Interleukin 4 Signaling by Interferon Regulatory Factor 4

1999 • 126 citations

Modular Nature of Blimp-1 in the Regulation of Gene Expression during B Cell Maturation

2004 • 119 citations

PRDM1/Blimp‐1 is expressed in human B‐lymphocytes committed to the plasma cell lineage

2005 • 108 citations

Cutting Edge: Polycomb Gene Expression Patterns Reflect Distinct B Cell Differentiation Stages in Human Germinal Centers

2000 • 94 citations

Clonal analysis of B cells induced to secrete IgG by T cell-derived lymphokine(s).

1984 • 87 citations

Review: The Role of IRF-4 in Transcriptional Regulation

2002 • 66 citations

Review: The Role of IRF-4 in B and T Cell Activation and Differentiation

2002 • 60 citations

E47, IRF-4, and PU.1 synergize to induce B-cell-specific activation of the class II transactivator promoter III (CIITA-PIII)

2004 • 56 citations

Blimp-1 over-expression abrogates IL-4- and CD40-mediated suppression of terminal B cell differentiation but arrests isotype switching.

2001 • 52 citations

Blimp-1 over-expression abrogates IL-4- and CD40-mediated suppression of terminal B cell differentiation but arrests isotype switching

2001 • 41 citations

Enhanced TCR-induced Apoptosis in Interferon Regulatory Factor 4–deficient CD4+ Th Cells

2004 • 36 citations

Mice deficient for the type II topoisomerase-like DNA transesterase Spo11 show normal immunoglobulin somatic hypermutation and class switching

2002 • 18 citations