Terminal differentiation of lymphocytes depends on Blimp-1

Plasma cell differentiation requires the transcription factor XBP-1

2001 • 1,256 citations

Blimp-1 Orchestrates Plasma Cell Differentiation by Extinguishing the Mature B Cell Gene Expression Program

2002 • 1,000 citations

Blimp1 is a critical determinant of the germ cell lineage in mice

2005 • 999 citations

XBP1, Downstream of Blimp-1, Expands the Secretory Apparatus and Other Organelles, and Increases Protein Synthesis in Plasma Cell Differentiation

2004 • 978 citations

Blimp-1 Is Required for the Formation of Immunoglobulin Secreting Plasma Cells and Pre-Plasma Memory B Cells

2003 • 797 citations

Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells

1994 • 752 citations

Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination

2006 • 725 citations

Regulation of B Cell Differentiation and Plasma Cell Generation by IL-21, a Novel Inducer of Blimp-1 and Bcl-6

2004 • 648 citations

IL-21 Induces Differentiation of Human Naive and Memory B Cells into Antibody-Secreting Plasma Cells

2005 • 641 citations

Graded Expression of Interferon Regulatory Factor-4 Coordinates Isotype Switching with Plasma Cell Differentiation

2006 • 527 citations

Plasma Cell Ontogeny Defined by Quantitative Changes in Blimp-1 Expression

2004 • 500 citations

Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells

2006 • 457 citations

Blimp-1-Dependent Repression of Pax-5 Is Required for Differentiation of B Cells to Immunoglobulin M-Secreting Plasma Cells

2002 • 427 citations

Repression of c- myc Transcription by Blimp-1, an Inducer of Terminal B Cell Differentiation

1997 • 412 citations

Blimp1 Defines a Progenitor Population that Governs Cellular Input to the Sebaceous Gland

2006 • 410 citations

Regulatory Mechanisms that Determine the Development and Function of Plasma Cells

2003 • 364 citations

Transcriptional repressor Blimp-1 regulates T cell homeostasis and function

2006 • 361 citations

Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma

2006 • 360 citations

Gene Repression by Pax5 in B Cells Is Essential for Blood Cell Homeostasis and Is Reversed in Plasma Cells

2006 • 354 citations

Identification and characterization of a novel repressor of beta-interferon gene expression.

1991 • 351 citations

Commitment of B Lymphocytes to a Plasma Cell Fate Is Associated with Blimp-1 Expression In Vivo

2000 • 337 citations

PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing

2004 • 335 citations

The zinc finger transcriptional repressor Blimp1/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouse

2005 • 332 citations

Transcriptional Repression by Blimp-1 (PRDI-BF1) Involves Recruitment of Histone Deacetylase

2000 • 328 citations

Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance

2006 • 305 citations

Early appearance of germinal center–derived memory B cells and plasma cells in blood after primary immunization

2005 • 254 citations

PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins

1999 • 248 citations

Regulation of Class-Switch Recombination and Plasma Cell Differentiation by Phosphatidylinositol 3-Kinase Signaling

2006 • 234 citations

Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow

2005 • 218 citations

Mutational analysis of PRDM1 indicates a tumor-suppressor role in diffuse large B-cell lymphomas

2006 • 218 citations

Loss of Pax5 Promotes Plasma Cell Differentiation

2006 • 216 citations

BLIMP-1 mediates extinction of major histocompatibility class II transactivator expression in plasma cells

2000 • 213 citations

Evidence from the generation of immunoglobulin G–secreting cells that stochastic mechanisms regulate lymphocyte differentiation

2003 • 199 citations

Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism

2006 • 198 citations

Role for Bcl-6 in the generation and maintenance of memory CD8[+] T cells

2002 • 192 citations

Cytokine-Dependent Blimp-1 Expression in Activated T Cells Inhibits IL-2 Production

2007 • 178 citations

The B-cell maturation factor Blimp-1 specifies vertebrate slow-twitch muscle fiber identity in response to Hedgehog signaling

2003 • 171 citations

CD4⁺ T‐cell memory: generation and multi‐faceted roles for CD4⁺ T cells in protective immunity to influenza

2006 • 162 citations

Stages of Germinal Center Transit Are Defined by B Cell Transcription Factor Coexpression and Relative Abundance

2006 • 133 citations

Modular Nature of Blimp-1 in the Regulation of Gene Expression during B Cell Maturation

2004 • 119 citations

PRDM1/Blimp‐1 is expressed in human B‐lymphocytes committed to the plasma cell lineage

2005 • 108 citations

Cutting Edge: Spontaneously Ig-Secreting B-1 Cells Violate the Accepted Paradigm for Expression of Differentiation-Associated Transcription Factors

2005 • 106 citations

Interleukin‐5 regulates genes involved in B‐cell terminal maturation

2006 • 102 citations

Repression of c-mycIs Necessary but Not Sufficient for Terminal Differentiation of B Lymphocytes In Vitro

2000 • 100 citations

Different Kinetics of Blimp-1 Induction in B Cell Subsets Revealed by Reporter Gene

2007 • 92 citations

Differential Effect of B Lymphocyte–induced Maturation Protein (Blimp-1) Expression on Cell Fate during B Cell Development

1998 • 90 citations

B-1 B lymphocytes require Blimp-1 for immunoglobulin secretion

2006 • 87 citations

Blimp-1 overcomes the block in IgM secretion in lipopolysaccharide / anti-μ F(ab′)2-co-stimulated B lymphocytes

1996 • 86 citations

Prdm1 acts downstream of a sequential RA, Wnt and Fgf signaling cascade during zebrafish forelimb induction

2006 • 64 citations

Differential Involvement of the Transcription Factor Blimp-1 in T Cell-Independent and -Dependent B Cell Differentiation to Plasma Cells

1999 • 56 citations

From naive to memory

1998 • 21 citations