Resistance to CpG DNA–induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling

A Toll-like receptor recognizes bacterial DNA

2000 • 6,348 citations

CpG motifs in bacterial DNA trigger direct B-cell activation

1995 • 3,543 citations

Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

2002 • 1,877 citations

Determination of lymphocyte division by flow cytometry

1994 • 1,712 citations

A Theory of Self-Nonself Discrimination

1970 • 1,700 citations

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

1988 • 1,562 citations

Differential activation of transcription factors induced by Ca2+ response amplitude and duration

1997 • 1,533 citations

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

A Hierarchical Role for Classical Pathway Complement Proteins in the Clearance of Apoptotic Cells in Vivo

2000 • 733 citations

Mechanism and Function of a Newly Identified CpG DNA Motif in Human Primary B Cells

2000 • 604 citations

Positive Selection of Natural Autoreactive B Cells

1999 • 574 citations

Induction of self-tolerance in mature peripheral B lymphocytes

1989 • 525 citations

Serum amyloid P component controls chromatin degradation and prevents antinuclear autoimmunity

1999 • 491 citations

Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice

1991 • 485 citations

CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+T cells

1995 • 470 citations

Genetic and Structural Evidence for Antigen Selection of Anti-DNA Antibodies

1994 • 464 citations

Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires.

1996 • 451 citations

Different Nuclear Signals Are Activated by the B Cell Receptor during Positive Versus Negative Signaling

1997 • 383 citations

Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells.

1994 • 340 citations

Breakdown of self-tolerance in anergic B lymphocytes

1991 • 254 citations

Decreased ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients

2001 • 253 citations

Immune Activation of B Cells: Evidence for‘One Nonspecific Triggering Signal' Not Delivered by the Ig Receptors

1974 • 244 citations

The Role of Somatic Mutation in the Pathogenic Anti-DNA Response

1992 • 244 citations

Receptor Selection in B and T Lymphocytes

2000 • 226 citations

How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis

2000 • 212 citations

Induction of anti-double stranded DNA antibodies in normal mice by immunization with bacterial DNA.

1989 • 202 citations

Antibodies to DN

1986 • 186 citations

Editors and Editing of Anti-DNA Receptors

2001 • 182 citations

DIABETOGENIC DRUGS

1976 • 180 citations

Induction of cross-reactive anti-dsDNA antibodies in preautoimmune NZB/NZW mice by immunization with bacterial DNA.

1995 • 177 citations

Most IgM-producing cells in the mouse secrete auto-antibodies (rheumatoid factor)

1978 • 175 citations

Oral administration of lipopolysaccharides activates B-1 cells in the peritoneal cavity and lamina propria of the gut and induces autoimmune symptoms in an autoantibody transgenic mouse.

1994 • 167 citations

IgM Rheumatoid Factors in Mice Injected with Bacterial Lipopolysaccharides

1979 • 161 citations

Antigen-specific induction of antibodies against native mammalian DNA in nonautoimmune mice.

1993 • 152 citations

Activation and Anergy in Bone Marrow B Cells of a Novel Immunoglobulin Transgenic Mouse that Is Both Hapten Specific and Autoreactive

2001 • 151 citations

High proportion of Ig-producing cells making autoantibody in normal mice

1978 • 136 citations

MRL-lpr/lpr Mice Exhibit a Defect in Maintaining Developmental Arrest and Follicular Exclusion of Anti–double-stranded DNA B Cells

1999 • 135 citations

Characterization of self-reactive B cells by polyclonal B-cell activators.

1977 • 125 citations

Tolerance to Self Gangliosides Is the Major Factor Restricting the Antibody Response to Lipopolysaccharide Core Oligosaccharides inCampylobacter jejuniStrains Associated with Guillain-Barré Syndrome

2002 • 108 citations

AUTOIMMUNE REACTIONS AND VIRUS-LIKE PARTICLES IN GERM-FREE NZB MICE

1967 • 102 citations

Peritoneal CD5+ B-1 Cells Have Signaling Properties Similar to Tolerant B Cells

2002 • 91 citations

Immune Complexes Present in the Sera of Autoimmune Mice Activate Rheumatoid Factor B Cells

2000 • 82 citations

Regulation of Anti-DNA B Cells in Recombination-activating Gene–deficient Mice

1998 • 82 citations

Spleen cells from animals tolerant to a thymus-dependent antigen can be activated by lipopolysaccharide to synthesize antibodies against the tolerogen.

1976 • 74 citations

Autoantigen-Specific B Cell Activation in FAS-Deficient Rheumatoid Factor Immunoglobulin Transgenic Mice

1999 • 74 citations

Characterization of anti-single-stranded DNA B cells in a non-autoimmune background.

1997 • 67 citations

Distinct Response of Human B Cell Subpopulations in Recognition of an Innate Immune Signal, CpG DNA

2002 • 62 citations

High affinity rheumatoid factor transgenic B cells are eliminated in normal mice.

1997 • 57 citations

B Cell Positive Selection by Soluble Self-Antigen

2002 • 57 citations

Multivalent cross-linking of membrane Ig sensitizes murine B cells to a broader spectrum of CpG-containing oligodeoxynucleotide motifs, including their methylated counterparts, for stimulation of proliferation and Ig secretion

1999 • 52 citations

B cells are anergic in transgenic mice that express IgM anti‐DNA antibodies

1993 • 44 citations

Immune response to DNA in systemic lupus erythematosus.

2001 • 30 citations

B Cell Anergy and Systemic Lupus Erythematosus

2002 • 16 citations