Regulation of Proliferation, Differentiation and Survival by the IL-3/IL-5/GM-CSF Receptor Family

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

STATs and Gene Regulation

1997 • 3,927 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

A family of cytokine-inducible inhibitors of signalling

1997 • 2,055 citations

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

1995 • 1,826 citations

A new protein containing an SH2 domain that inhibits JAK kinases

1997 • 1,413 citations

Signalling through the lipid products of phosphoinositide-3-OH kinase

1997 • 1,314 citations

Structure and function of a new STAT-induced STAT inhibitor

1997 • 1,308 citations

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

1997 • 1,306 citations

CYTOKINES: COORDINATORS OF IMMUNE AND INFLAMMATORY RESPONSES

1990 • 1,304 citations

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 • 1,026 citations

Specific Inhibition of Stat3 Signal Transduction by PIAS3

1997 • 971 citations

A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors.

1995 • 761 citations

Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene

1993 • 756 citations

PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

1997 • 699 citations

Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.

1995 • 641 citations

A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells.

1996 • 589 citations

Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene

1993 • 578 citations

Bcl-2 Phosphorylation Required for Anti-apoptosis Function

1997 • 540 citations

CIS, a Cytokine Inducible SH2 Protein, Is a Target of the JAK-STAT5 Pathway and Modulates STAT5 Activation

1997 • 538 citations

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

1997 • 534 citations

JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region.

1994 • 506 citations

Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production.

1993 • 488 citations

Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation.

1996 • 414 citations

Signal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signaling.

1993 • 383 citations

STAT3β, a Splice Variant of Transcription Factor STAT3, Is a Dominant Negative Regulator of Transcription

1996 • 378 citations

Interleukin 3-dependent survival by the Akt protein kinase

1997 • 374 citations

Tyrosine Phosphorylation of DNA Binding Proteins by Multiple Cytokines

1993 • 367 citations

Involvement of ras p21 protein in signal-transduction pathways from interleukin 2, interleukin 3, and granulocyte/macrophage colony-stimulating factor, but not from interleukin 4.

1991 • 351 citations

STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line.

1996 • 345 citations

Hematopoietic Cell Phosphatase Associates with the Interleukin-3 (IL-3) Receptor β Chain and Down-Regulates IL-3-Induced Tyrosine Phosphorylation and Mitogenesis

1993 • 340 citations

Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2.

1993 • 336 citations

Interleukin-3 signals through multiple isoforms of Stat5.

1995 • 327 citations

Cloning of Murine Stat6 and Human Stat6, Stat Proteins That Are Tyrosine Phosphorylated in Responses to IL-4 and IL-3 but Are Not Required for Mitogenesis

1995 • 325 citations

Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors.

1995 • 321 citations

Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen-activated protein kinases

1997 • 314 citations

Mice deficient for the IL-3/GM-CSF/IL-5 βc receptor exhibit lung pathology and impaired immune response, while βIL3 receptor-deficient mice are normal

1995 • 313 citations

Hematopoietic and lung abnormalities in mice with a null mutation of the common beta subunit of the receptors for granulocyte-macrophage colony-stimulating factor and interleukins 3 and 5.

1995 • 311 citations

Signal transduction of the human granulocyte-macrophage colony- stimulating factor and interleukin-3 receptors involves tyrosine phosphorylation of a common set of cytoplasmic proteins

1990 • 294 citations

Deletion of the Carboxyl-Terminal Transactivation Domain of MGF-Stat5 Results in Sustained DNA Binding and a Dominant Negative Phenotype

1996 • 276 citations

Naturally Occurring Dominant Negative Variants of Stat5

1996 • 270 citations

Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand.

1993 • 267 citations

Cloning and Characterization of Novel CIS Family Genes

1997 • 259 citations

The proto-oncogene product p120CBL and the adaptor proteins CRKL and c-CRK link c-ABL, p190BCR/ABL and p210BCR/ABL to the phosphatidylinositol-3' kinase pathway.

1996 • 259 citations

Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils.

1996 • 238 citations

Mouse oncostatin M: an immediate early gene induced by multiple cytokines through the JAK-STAT5 pathway.

1996 • 224 citations

Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activation.

1996 • 223 citations

R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways

1997 • 223 citations

p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein.

1992 • 213 citations

Granulocyte-macrophage colony-stimulating factor, interleukin-3, and steel factor induce rapid tyrosine phosphorylation of p42 and p44 MAP kinase

1992 • 210 citations

Granulocyte macrophage-colony stimulating factor stimulates both association and activation of phosphoinositide 3OH-kinase and src-related tyrosine kinase(s) in human myeloid derived cells.

1993 • 208 citations

Two distinct functional high affinity receptors for mouse interleukin-3 (IL-3).

1992 • 206 citations

Activation of the Janus Kinase/STAT (Signal Transducer and Activator of Transcription) Signal Transduction Pathway by Interleukin-6-Type Cytokines Promotes Osteoblast Differentiation*

1997 • 206 citations

Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis.

1993 • 204 citations

The Structural and Functional Basis of Cytokine Receptor Activation: Lessons From the Common β Subunit of the Granulocyte-Macrophage Colony-Stimulating Factor, Interleukin-3 (IL-3), and IL-5 Receptors

1997 • 193 citations

Investigation of neutrophil signal transduction using a specific inhibitor of phosphatidylinositol 3-kinase.

1995 • 184 citations

Involvement of STAT3 in the Granulocyte Colony-stimulating Factor-induced Differentiation of Myeloid Cells

1997 • 183 citations

STAT5A-Deficient Mice Demonstrate a Defect in Granulocyte-Macrophage Colony-Stimulating Factor–Induced Proliferation and Gene Expression

1997 • 180 citations

The Proto-oncogene Product c-Cbl Becomes Tyrosine Phosphorylated by Stimulation with GM-CSF or Epo and Constitutively Binds to the SH3 Domain of Grb2/Ash in Human Hematopoietic Cells

1995 • 179 citations

Interleukin-3 and granulocyte-macrophage colony-stimulating factor mediate rapid phosphorylation and activation of cytosolic c-raf.

1990 • 179 citations

IL-5 receptor-mediated tyrosine phosphorylation of SH2/SH3-containing proteins and activation of Bruton's tyrosine and Janus 2 kinases.

1994 • 178 citations

Granulocyte-macrophage colony-stimulating factor, interleukin-3, and steel factor induce rapid tyrosine phosphorylation of p42 and p44 MAP kinase

1992 • 176 citations

Comparison of the roles of mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase signal transduction in neutrophil effector function

1998 • 173 citations

The intracellular signal transduction mechanism of interleukin 5 in eosinophils: the involvement of lyn tyrosine kinase and the Ras-Raf-1-MEK-microtubule-associated protein kinase pathway.

1995 • 168 citations

Multiple cytokines activate phosphatidylinositol 3-kinase in hemopoietic cells. Association of the enzyme with various tyrosine-phosphorylated proteins.

1994 • 159 citations

An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT

1997 • 158 citations

Functionally Distinct Isoforms of STAT5 Are Generated by Protein Processing

1997 • 155 citations

A1, a Bcl-2 family member, prolongs cell survival and permits myeloid differentiation

1996 • 153 citations

Regulation of Bcl-2 expression by oncogenic Ras protein in hematopoietic cells.

1995 • 151 citations

The Amino-terminal Portion of the JAK2 Protein Kinase Is Necessary For Binding and Phosphorylation of the Granulocyte-Macrophage Colony-stimulating Factor Receptor β Chain

1995 • 148 citations

Constitutive activation of mitogen-activated protein kinase pathway in acute leukemia cells

1997 • 147 citations

Multiple hemopoietic growth factors stimulate activation of mitogen-activated protein kinase family members.

1992 • 147 citations

G-Protein-coupled Receptors and Fcγ-receptors Mediate Activation of Akt/Protein Kinase B in Human Phagocytes

1997 • 146 citations

Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3'-kinase.

1994 • 144 citations

A Critical Cytoplasmic Domain of the Interleukin-5 (IL-5) Receptor α Chain and Its Function in IL-5-Mediated Growth Signal Transduction

1994 • 139 citations

Interleukin-5, interleukin-3, and granulocyte-macrophage colony-stimulating factor cross-compete for binding to cell surface receptors on human eosinophils.

1991 • 136 citations

JAK2 Is Essential for Activation of c-fos and c-myc Promoters and Cell Proliferation through the Human Granulocyte-Macrophage Colony-stimulating Factor Receptor in BA/F3 Cells

1996 • 133 citations

Granulocyte-Macrophage Colony-stimulating Factor Stimulates JAK2 Signaling Pathway and Rapidly Activates p93 , STAT1 p91, and STAT3 p92 in Polymorphonuclear Leukocytes

1996 • 133 citations

Tyrosine phosphorylation and activation of a new mitogen-activated protein (MAP)-kinase cascade in human neutrophils stimulated with various agonists

1996 • 131 citations

Common subunits of cytokine receptors and the functional redundancy of cytokines

1992 • 131 citations

A novel pathway from phosphorylation of tyrosine residues 239/240 of Shc, contributing to suppress apoptosis by IL-3.

1996 • 131 citations

Constitutive activation of protein kinase B and phosphorylation of p47 phox by a membrane-targeted phosphoinositide 3-kinase

1996 • 130 citations

Interleukin-3 regulates the activity of the LYN protein-tyrosine kinase in myeloid-committed leukemic cell lines

1992 • 128 citations

Interleukin-3, Erythropoietin, and Prolactin Activate a STAT5-like Factor in Lymphoid Cells

1995 • 128 citations

Critical role of Lyn kinase in inhibition of neutrophil apoptosis by granulocyte-macrophage colony-stimulating factor.

1996 • 127 citations

Antagonists of Phosphatidylinositol 3-Kinase Block Activation of Several Novel Protein Kinases in Neutrophils

1995 • 127 citations

Interleukin-5 signaling in human eosinophils involves JAK2 tyrosine kinase and Stat1 alpha

1995 • 125 citations

Analysis of Signal Transduction Pathways in Human Eosinophils Activated by Chemoattractants and the T-Helper 2–Derived Cytokines Interleukin-4 and Interleukin-5

1998 • 123 citations

Role of phosphatidylinositol 3-OH-kinase activity in the inhibition of apoptosis in haemopoietic cells: phosphatidylinositol 3-OH-kinase inhibitors reveal a difference in signalling between interleukin-3 and granulocyte-macrophage colony stimulating factor

1995 • 121 citations

Raf/MAPK and rapamycin-sensitive pathways mediate the anti-apoptotic function of p21Ras in IL-3-dependent hematopoietic cells

1997 • 118 citations

v-raf suppresses apoptosis and promotes growth of interleukin-3-dependent myeloid cells.

1994 • 111 citations

Activation of JNK Signaling Pathway by Erythropoietin, Thrombopoietin, and Interleukin-3

1997 • 110 citations

The Kinase Domain of Jak2 Mediates Induction of Bcl-2 and Delays Cell Death in Hematopoietic Cells

1997 • 107 citations

Overexpression of Shc proteins potentiates the proliferative response to the granulocyte-macrophage colony-stimulating factor and recruitment of Grb2/SoS and Grb2/p140 complexes to the beta receptor subunit.

1995 • 107 citations

Convergence of signaling by interleukin-3, granulocyte-macrophage colony-stimulating factor, and mast cell growth factor on JAK2 tyrosine kinase.

1994 • 106 citations

Hematologic abnormalities of the immunodeficient mouse mutant, viable motheaten (mev).

1989 • 105 citations

Interleukin-3, granulocyte-macrophage colony-stimulating factor, and interleukin-5 transduce signals through two forms of STAT5

1995 • 105 citations

Granulocyte-macrophage colony-stimulating factor and interleukin-3 induce rapid phosphorylation and activation of the proto-oncogene Raf-1 in a human factor-dependent myeloid cell line

1991 • 105 citations

Effects of interleukin-3 and c-kit ligand on the survival of various classes of human hematopoietic progenitor cells

1994 • 99 citations

Erythropoietin and Interleukin-3 Activate Tyrosine Phosphorylation of CBL and Association With CRK Adaptor Proteins

1997 • 97 citations

Granulocyte-macrophage Colony-stimulating Factor Provokes RAS Activation and Transcription of c-fos through Different Modes of Signaling

1996 • 95 citations

Effects of interleukin-3 and c-kit ligand on the survival of various classes of human hematopoietic progenitor cells

1994 • 94 citations

Src Homology 2 Protein Tyrosine Phosphatase (SHPTP2)/Src Homology 2 Phosphatase 2 (SHP2) Tyrosine Phosphatase Is a Positive Regulator of the Interleukin 5 Receptor Signal Transduction Pathways Leading to the Prolongation of Eosinophil Survival

1997 • 93 citations

Granulocyte-macrophage colony-stimulating factor preferentially activates the 94-kD STAT5A and an 80-kD STAT5A isoform in human peripheral blood monocytes

1996 • 93 citations

A Single Tyrosine Residue in the Membrane-proximal Domain of the Granulocyte-Macrophage Colony-stimulating Factor, Interleukin (IL)-3, and IL-5 Receptor Common β-Chain Is Necessary and Sufficient for High Affinity Binding and Signaling by All Three Ligands

1996 • 92 citations

A critical cytoplasmic domain of the interleukin-5 (IL-5) receptor alpha chain and its function in IL-5-mediated growth signal transduction.

1994 • 91 citations

STAT5 Activation Correlates with Erythropoietin Receptor-mediated Erythroid Differentiation of an Erythroleukemia Cell Line

1997 • 90 citations

Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain.

1995 • 90 citations

Activation of p38 MAP Kinase Pathway by Erythropoietin and Interleukin-3

1997 • 89 citations

Function and Signal Transduction Mediated by the Interleukin 3 Receptor System in Hematopoiesis

1996 • 87 citations

IL-5 but not interferon-gamma (IFN-γ) inhibits eosinophil apoptosis by up-regulation of bcl-2 expression

1997 • 86 citations

Intracellular Tyrosine Residues of the Human Growth Hormone Receptor Are Not Required for the Signaling of Proliferation or Jak-STAT Activation

1995 • 86 citations

Cytokines and Growth factors signal through tyrosine phosphorylation of a family of related transcription factors

1994 • 84 citations

Physical and functional interactions between Stat5 and the tyrosine- phosphorylated receptors for erythropoietin and interleukin-3

1996 • 82 citations

Evidence for a Physical Association between the Shc-PTB Domain and the βc Chain of the Granulocyte-Macrophage Colony-stimulating Factor Receptor

1996 • 82 citations

Interleukin-3 Induces the Association of the Inositol 5-Phosphatase SHIP with SHP2

1997 • 81 citations

Activation of the Stress-Activated Protein Kinases by Multiple Hematopoietic Growth Factors With the Exception of Interleukin-4

1997 • 81 citations

The Cytoplasmic Domain of Granulocyte-Macrophage Colony-stimulating Factor (GM-CSF) Receptor α Subunit Is Essential for Both GM-CSF-mediated Growth and Differentiation

1997 • 81 citations

Inhibition of interleukin 3 and granulocyte-macrophage colony-stimulating factor stimulated increase of active ras.GTP by herbimycin A, a specific inhibitor of tyrosine kinases.

1992 • 78 citations

Activation of the STAT3/Acute Phase Response Factor Transcription Factor by Interleukin-5

1995 • 77 citations

Activation of src-related tyrosine kinases by IL-3.

1995 • 77 citations

Human interleukin-3 receptor modulates bcl-2 mRNA and protein levels through protein kinase C in TF-1 cells

1995 • 77 citations

STAT3 and STAT5B Are Targets of Two Different Signal Pathways Activated by Hematopoietin Receptors and Control Transcription via Separate Cytokine Response Elements

1995 • 76 citations

Tec protein-tyrosine kinase is involved in interleukin-3 signaling pathway

1995 • 75 citations

Phosphorylation of Cbl following Stimulation with Interleukin-3 and Its Association with Grb2, Fyn, and Phosphatidylinositol 3-Kinase

1997 • 75 citations

Critical proline residues of the cytoplasmic domain of the IL-5 receptor α chain and its function in IL-5-mediated activation of JAK kinase and STAT5

1996 • 74 citations

A role for JNK/SAPK in proliferation, but not apoptosis, of IL-3-dependent cells

1997 • 73 citations

Prolactin and interleukin-2 receptors in T lymphocytes signal through a MGF-STAT5-like transcription factor.

1995 • 71 citations

Cytoplasmic domains of the common beta -chain of the GM-CSF/IL-3/IL-5 receptors that are required for inducing differentiation or clonal suppression in myeloid leukaemic cell lines

1997 • 70 citations

SHP1 and SHP2 Protein-tyrosine Phosphatases Associate with βc after Interleukin-3-induced Receptor Tyrosine Phosphorylation

1997 • 69 citations

Ras Is Not Required for the Interleukin 3-induced Proliferation of a Mouse Pro-B Cell Line, BaF3

1995 • 68 citations

Association of phosphatidylinositol 3-kinase with SHC in chronic myelogeneous leukemia cells.

1995 • 66 citations

Granulocyte-macrophage colony-stimulating factor-induced protein tyrosine phosphorylation of microtubule-associated protein kinase in human neutrophils.

1992 • 66 citations

Inhibition of neutrophil oxidative burst and granule secretion by Wortmannin: Potential role of MAP kinase and renaturable kinases

1997 • 65 citations

Functional inactivation in mice of the gene for the interleukin-3 (IL- 3)-specific receptor beta-chain: implications for IL-3 function and the mechanism of receptor transmodulation in hematopoietic cells

1996 • 65 citations

Involvement of p59fynT in interleukin-5 receptor signaling.

1995 • 65 citations

IL-5 activates a 45-kilodalton mitogen-activated protein (MAP) kinase and Jak-2 tyrosine kinase in human eosinophils.

1996 • 62 citations

The Human Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF ) Receptor Exists as a Preformed Receptor Complex That Can Be Activated by GM-CSF, Interleukin-3, or Interleukin-5

1997 • 62 citations

Granulocyte-Macrophage Colony-Stimulating Factor–Activated Signaling Pathways in Human Neutrophils. I. Tyrosine Phosphorylation-Dependent Stimulation of Phosphatidylinositol 3-Kinase and Inhibition by Phorbol Esters

1997 • 60 citations

The beta subunit of human granulocyte-macrophage colony-stimulating factor receptor forms a homodimer and is activated via association with the alpha subunit.

1996 • 59 citations

Granulocyte signal transduction and priming: cause without effect?

1997 • 59 citations

Granulocyte-macrophage colony-stimulating factor activates microtubule- associated protein 2 kinase in neutrophils via a tyrosine kinase- dependent pathway

1992 • 57 citations

In bone marrow derived Baf-3 cells, inhibition of apoptosis by IL-3 is mediated by two independent pathways

1997 • 56 citations

The role of MAP kinase kinase in interleukin-3 stimulation of proliferation

1996 • 56 citations

Identification of a viability domain in the granulocyte/macrophage colony-stimulating factor receptor beta-chain involving tyrosine-750.

1995 • 56 citations

Roles of JAK kinases in human GM-CSF receptor signal transduction

1996 • 56 citations

Direct stimulation by tyrosine phosphorylation of microtubule-associated protein (MAP) kinase activity by granulocyte-macrophage colony-stimulating factor in human neutrophils

1993 • 55 citations

Signaling Functions of the Tyrosine Residues in the βc Chain of the Granulocyte-Macrophage Colony-Stimulating Factor Receptor

1997 • 52 citations

Raf-1 protein is required for growth factor-induced proliferation of hematopoietic cells.

1995 • 50 citations

A Membrane Proximal Domain of the Human Interleukin-3 Receptor βc Subunit That Signals DNA Synthesis in NIH 3T3 Cells Specifically Binds a Complex of Src and Janus Family Tyrosine Kinases and Phosphatidylinositol 3-Kinase

1995 • 50 citations

Erythropoietin and IL-3 Induce Tyrosine Phosphorylation of CrkL and Its Association with Shc, SHP-2, and Cbl in Hematopoietic Cells

1997 • 49 citations

Ras-dependent Activation of c-Jun N-terminal Kinase/Stress-activated Protein Kinase in Response to Interleukin-3 Stimulation in Hematopoietic BaF3 Cells

1997 • 49 citations

An activated mutant of R-Ras inhibits cell death caused by cytokine deprivation in BaF3 cells in the presence of IGF-I

1997 • 48 citations

Identification of a New Adapter Protein That May Link the Common β Subunit of the Receptor for Granulocyte/Macrophage Colony-stimulating Factor, Interleukin (IL)-3, and IL-5 to Phosphatidylinositol 3-Kinase

1995 • 47 citations

Activation of 12-O-Tetradecanoylphorbol-13-acetate Response Element- and Dyad Symmetry Element-dependent Transcription by Interleukin-5 Is Mediated by Jun N-terminal Kinase/Stress-activated Protein Kinase Kinases

1997 • 47 citations

Characterization of critical residues in the cytoplasmic domain of the human interleukin‐5 receptor α chain required for growth signal transduction

1995 • 47 citations

Inhibition of p21ras activation blocks proliferation but not differentiation of interleukin-3-dependent myeloid cells.

1994 • 46 citations

Purification and Molecular Cloning of SH2- and SH3-Containing Inositol Polyphosphate-5-Phosphatase, Which Is Involved in the Signaling Pathway of Granulocyte-Macrophage Colony-Stimulating Factor, Erythropoietin, and Bcr-Abl

1997 • 46 citations

A critical role for the cytoplasmic domain of the granulocyte-macrophage colony-stimulating factor alpha receptor in mediating cell growth.

1993 • 46 citations

Activation of 70‐kDa S6 kinase, induced by the cytokines interleukin‐3 and erythropoietin and inhibited by rapamycin, is not an absolute requirement for cell proliferation

1994 • 45 citations

Binding of src-like Kinases to the β-Subunit of the Interleukin-3 Receptor

1997 • 44 citations

Mapping the intracytoplasmic regions of the alpha granulocyte-macrophage colony-stimulating factor receptor necessary for cell growth regulation.

1994 • 42 citations

Granulocyte‐macrophage colony‐stimulating factor induces a unique set of STAT factors in murine dendritic cells

1997 • 42 citations

A Dominant Negative Granulocyte-Macrophage Colony-stimulating Factor Receptor α Chain Reveals the Multimeric Structure of the Receptor Complex

1996 • 38 citations

Tyrosine phosphorylation of Shc is not required for proliferation or viability signaling by granulocyte-macrophage colony-stimulating factor in hematopoietic cell lines.

1996 • 37 citations

Evidence for a signaling role for the alpha chains of granulocyte- macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 receptors: divergent signaling pathways between GM-CSF/IL-3 and IL-5

1995 • 33 citations

Characterization of cis-regulatory elements of the c-myc promoter responding to human GM-CSF or mouse interleukin 3 in mouse proB cell line BA/F3 cells expressing the human GM-CSF receptor.

1995 • 32 citations

Interleukin 3 Activates Not Only JAK2 and STAT5, but Also Tyk2, STAT1, and STAT3

1996 • 30 citations

STAT5 involvement in the differentiation response of primary chicken myeloid progenitor cells to chicken myelomonocytic growth factor.

1997 • 29 citations

Focal Adhesion Kinase Upregulated by Granulocyte-Macrophage Colony-Stimulating Factor But Not by Interleukin-3 in Differentiating Myeloid Cells

1997 • 28 citations

Multiple tyrosine residues in the intracellular domain of the common β subunit of the interleukin 5 receptor are involved in activation of STAT5

1997 • 26 citations

Association between Lyn protein tyrosine kinase (p53/56lyn) and the beta subunit of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptors in a GM-CSF-dependent human megakaryocytic leukemia cell line (M-07e).

1995 • 26 citations

Tyrosine Phosphorylation of p38 but Not Extracellular Signal-Regulated Kinase in Normal Human Neutrophils Stimulated by Tumor Necrosis Factor: Comparative Study with Granulocyte-Macrophage Colony-Stimulating Factor

1997 • 23 citations

A Novel Phosphatidylinositol-3,4,5-trisphosphate 5-Phosphatase Associates with the Interleukin-3 Receptor

1996 • 21 citations

Conserved amino acids in the human granulocyte-macrophage colony-stimulating factor receptor-binding subunit essential for tyrosine phosphorylation and proliferation.

1995 • 18 citations

A Role for STAT Family Transcription Factors in Myeloid Differentiation

1996 • 12 citations

Function of the Common β Subunit of the GM-CSF/IL-3/IL-5 Receptors

1994 • 10 citations

Identification of Genes Induced by Interleukin-3 and Erythropoietin via the Jak-Stat5 Pathway Using Enhanced Differential Display-Reverse Southern

1997 • 10 citations

p91 STAT1 activation in interleukin-3-stimulated primary acute myeloid leukemia cells.

1996 • 10 citations

Reconstitution of the Functional lnterleukin-5 Receptor: The Cytoplasmic Domain of Alpha-Subunit Plays an Important Role in Growth Signal Transduction

1994 • 8 citations