Caveolin-1 regulates cell polarization and directional migration through Src kinase and Rho GTPases

Cutaneous Wound Healing

1999 • 5,878 citations

Cell Migration: Integrating Signals from Front to Back

2003 • 4,755 citations

Rho and Rac Take Center Stage

2004 • 1,797 citations

Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted Mice

2001 • 1,517 citations

Cell migration: Rho GTPases lead the way

2003 • 1,412 citations

Caveolin-1 Null Mice Are Viable but Show Evidence of Hyperproliferative and Vascular Abnormalities

2001 • 1,144 citations

Rac Downregulates Rho Activity

1999 • 840 citations

Spatiotemporal dynamics of RhoA activity in migrating cells

2006 • 809 citations

Efficient and Rapid Induction of a Chronic Myelogenous Leukemia-Like Myeloproliferative Disease in Mice Receiving P210 bcr/abl-Transduced Bone Marrow

1998 • 756 citations

A Requirement for Caveolin-1 and Associated Kinase Fyn in Integrin Signaling and Anchorage-Dependent Cell Growth

1998 • 720 citations

Divergent Signals and Cytoskeletal Assemblies Regulate Self-Organizing Polarity in Neutrophils

2003 • 690 citations

Interplay between Rac and Rho in the control of substrate contact dynamics

1999 • 623 citations

Leukocyte polarization in cell migration and immune interactions

1999 • 622 citations

Assembly and mechanosensory function of focal contacts

2001 • 548 citations

Redox-dependent downregulation of Rho by Rac

2003 • 508 citations

Integrin signaling to the actin cytoskeleton

2003 • 497 citations

Role of plasmalemmal caveolae in signal transduction

1998 • 466 citations

Novel tyrosine kinase substrates from Rous sarcoma virus-transformed cells are present in the membrane skeleton.

1989 • 457 citations

Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK

2000 • 454 citations

Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover

2000 • 454 citations

A Rac switch regulates random versus directionally persistent cell migration

2005 • 449 citations

RhoA Inactivation by p190RhoGAP Regulates Cell Spreading and Migration by Promoting Membrane Protrusion and Polarity

2001 • 431 citations

Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism

2000 • 429 citations

Phospho-caveolin-1 mediates integrin-regulated membrane domain internalization

2005 • 414 citations

A Role for Caveolin and the Urokinase Receptor in Integrin-mediated Adhesion and Signaling

1999 • 402 citations

Directional Sensing Requires Gβγ-Mediated PAK1 and PIXα-Dependent Activation of Cdc42

2003 • 380 citations

Role of Actin Polymerization and Adhesion to Extracellular Matrix in Rac- and Rho-induced Cytoskeletal Reorganization

1997 • 378 citations

Cell migration at a glance

2005 • 370 citations

Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion

2004 • 352 citations

Integrin-dependent actomyosin contraction regulates epithelial cell scattering

2005 • 319 citations

Identification of Filamin as a Novel Ligand for Caveolin-1: Evidence for the Organization of Caveolin-1–associated Membrane Domains by the Actin Cytoskeleton

2000 • 303 citations

Biogenesis of caveolae: a structural model for caveolin-induced domain formation

2006 • 291 citations

p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasciculation

2001 • 245 citations

Rho GTPases control migration and polarization of adhesion molecules and cytoskeletal ERM components in T lymphocytes

1999 • 229 citations

Caveolin-1 Expression Is Critical for Vascular Endothelial Growth Factor–Induced Ischemic Hindlimb Collateralization and Nitric Oxide–Mediated Angiogenesis

2004 • 224 citations

An α4 integrin–paxillin–Arf-GAP complex restricts Rac activation to the leading edge of migrating cells

2005 • 206 citations

The inner lives of focal adhesions

2002 • 206 citations

A Phosphotyrosine-dependent Protein Interaction Screen Reveals a Role for Phosphorylation of Caveolin-1 on Tyrosine 14

2002 • 203 citations

Cell migration as a five-step cycle.

1999 • 193 citations

Localized RhoA Activation as a Requirement for the Induction of Membrane Ruffling

2005 • 188 citations

Caveolae Are a Novel Pathway for Membrane-Type 1 Matrix Metalloproteinase Traffic in Human Endothelial Cells

2003 • 170 citations

Rac1 Function Is Required for Src-induced Transformation

2003 • 166 citations

Cadherin Engagement Inhibits RhoA via p190RhoGAP

2003 • 164 citations

A role for caveolae in cell migration

2004 • 152 citations

Getting rid of caveolins: Phenotypes of caveolin-deficient animals

2005 • 151 citations

Differential Caveolin-1 Polarization in Endothelial Cells during Migration in Two and Three Dimensions

2003 • 146 citations

Loss of Caveolin-1 Polarity Impedes Endothelial Cell Polarization and Directional Movement

2004 • 145 citations

Involvement of the c-Src-Crk-C3G-Rap1 Signaling in the Nectin-induced Activation of Cdc42 and Formation of Adherens Junctions

2004 • 142 citations

Integrin mechanotransduction stimulates caveolin-1 phosphorylation and recruitment of Csk to mediate actin reorganization

2004 • 138 citations

Small Interfering RNA-mediated Down-regulation of Caveolin-1 Differentially Modulates Signaling Pathways in Endothelial Cells

2004 • 136 citations

Caveolin-1 Knockout Mice Show an Impaired Angiogenic Response to Exogenous Stimuli

2003 • 131 citations

Sites of Ca2+ wave initiation move with caveolae to the trailing edge of migrating cells

2002 • 127 citations

Ubiquitin-dependent degradation of active Src

1999 • 122 citations

Caveolin-1 Inhibits Epidermal Growth Factor-stimulated Lamellipod Extension and Cell Migration in Metastatic Mammary Adenocarcinoma Cells (MTLn3)

2000 • 122 citations

Epidermal Growth Factor-dependent Regulation of Cdc42 Is Mediated by the Src Tyrosine Kinase

2003 • 111 citations

Vav2 as a Rac-GDP/GTP Exchange Factor Responsible for the Nectin-induced, c-Src- and Cdc42-mediated Activation of Rac

2004 • 87 citations

Caveolin-1 Is Required for Vascular Endothelial Growth Factor-Triggered Multiple Myeloma Cell Migration and Is Targeted by Bortezomib

2004 • 84 citations

DIP (mDia interacting protein) is a key molecule regulating Rho and Rac in a Src-dependent manner

2004 • 66 citations

Caveolin-1 Is Not Required for Murine Intestinal Cholesterol Transport

2005 • 64 citations

Src Kinase Regulates the Activation of a Novel FGD-1-related Cdc42 Guanine Nucleotide Exchange Factor in the Signaling Pathway from the Endothelin A Receptor to JNK

2003 • 63 citations

Caveolin-1-deficient aortic smooth muscle cells show cell autonomous abnormalities in proliferation, migration, and endothelin-based signal transduction

2006 • 61 citations

Caveolin-1 Knockdown by Small Interfering RNA Suppresses Responses to the Chemokine Monocyte Chemoattractant Protein-1 by Human Astrocytes

2004 • 56 citations