Getting rid of caveolins: Phenotypes of caveolin-deficient animals

Caveolin, a protein component of caveolae membrane coats

1992 • 2,230 citations

Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted Mice

2001 • 1,517 citations

Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER

2001 • 1,236 citations

Caveolin-1 Null Mice Are Viable but Show Evidence of Hyperproliferative and Vascular Abnormalities

2001 • 1,144 citations

Molecular mechanisms of blood vessel growth

2001 • 999 citations

VIP21/caveolin is a cholesterol-binding protein.

1995 • 892 citations

Acylation Targets Endothelial Nitric-oxide Synthase to Plasmalemmal Caveolae

1996 • 798 citations

Proteomic Analysis of Proteins Associated with Lipid Droplets of Basal and Lipolytically Stimulated 3T3-L1 Adipocytes

2004 • 772 citations

Regulated internalization of caveolae.

1994 • 760 citations

Molecular Cloning of Caveolin-3, a Novel Member of the Caveolin Gene Family Expressed Predominantly in Muscle

1996 • 737 citations

Local Actin Polymerization and Dynamin Recruitment in SV40-Induced Internalization of Caveolae

2002 • 715 citations

Endocytosis Via Caveolae

2002 • 708 citations

Expression of Caveolin-3 in Skeletal, Cardiac, and Smooth Muscle Cells

1996 • 692 citations

Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling.

1996 • 677 citations

Vascular Endothelial Growth Factor Induces Endothelial Fenestrations In Vitro

1998 • 638 citations

Reciprocal Regulation of Endothelial Nitric-oxide Synthase by Ca2+-Calmodulin and Caveolin

1997 • 610 citations

Mutations in the caveolin-3 gene cause autosomal dominant limb-girdle muscular dystrophy

1998 • 590 citations

Lipid Rafts and Caveolae as Portals for Endocytosis: New Insights and Common Mechanisms

2003 • 589 citations

In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation

2000 • 558 citations

Caveolin-1-deficient Mice Are Lean, Resistant to Diet-induced Obesity, and Show Hypertriglyceridemia with Adipocyte Abnormalities

2002 • 557 citations

VIP21, a 21-kD membrane protein is an integral component of trans-Golgi-network-derived transport vesicles.

1992 • 544 citations

Cell-type and Tissue-specific Expression of Caveolin-2

1997 • 524 citations

Caveolin-1 in oncogenic transformation, cancer, and metastasis

2005 • 516 citations

Chinese Hamster Ovary K2 Cell Lipid Droplets Appear to Be Metabolic Organelles Involved in Membrane Traffic

2004 • 514 citations

Structure of Detergent-Resistant Membrane Domains: Does Phase Separation Occur in Biological Membranes?

1997 • 512 citations

Reduction of caveolin and caveolae in oncogenically transformed cells.

1995 • 505 citations

Sequestration of GPI-Anchored Proteins in Caveolae Triggered by Cross-Linking

1994 • 505 citations

Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade

1998 • 473 citations

Caveolin-3 Null Mice Show a Loss of Caveolae, Changes in the Microdomain Distribution of the Dystrophin-Glycoprotein Complex, and T-tubule Abnormalities

2001 • 450 citations

Clathrin- and caveolin-1–independent endocytosis

2005 • 443 citations

Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells

1998 • 435 citations

Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice

2002 • 434 citations

Ultrastructural identification of uncoated caveolin-independent early endocytic vehicles

2005 • 431 citations

Caveolin‐mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo

1998 • 371 citations

Role of GTP Hydrolysis in Fission of Caveolae Directly from Plasma Membranes

1996 • 370 citations

Tyrosine Phosphorylation of a 22-kDa Protein Is Correlated with Transformation by Rous Sarcoma Virus

1989 • 363 citations

Caveolin-3 Associates with Developing T-tubules during Muscle Differentiation

1997 • 345 citations

Caveolin-1-deficient mice show insulin resistance and defective insulin receptor protein expression in adipose tissue

2003 • 344 citations

Caveolae-deficient Endothelial Cells Show Defects in the Uptake and Transport of Albumin in Vivo

2001 • 325 citations

Caveolin-2-Deficient Mice Show Evidence of Severe Pulmonary Dysfunction without Disruption of Caveolae

2002 • 318 citations

A Caveolin Dominant Negative Mutant Associates with Lipid Bodies and Induces Intracellular Cholesterol Imbalance

2001 • 313 citations

Microvascular Hyperpermeability in Caveolin-1 (−/−) Knock-out Mice

2002 • 311 citations

Regulation of caveolin and caveolae by cholesterol in MDCK cells

1998 • 307 citations

Role of Caveolin-1 in the Modulation of Lipolysis and Lipid Droplet Formation

2004 • 303 citations

Caveolin Is an Activator of Insulin Receptor Signaling

1998 • 297 citations

Caveolin-3 Knock-out Mice Develop a Progressive Cardiomyopathy and Show Hyperactivation of the p42/44 MAPK Cascade

2002 • 283 citations

Caveolin-1 Gene Disruption Promotes Mammary Tumorigenesis and Dramatically Enhances Lung Metastasis in Vivo

2004 • 280 citations

Two sterol regulatory element-like sequences mediate up-regulation of caveolin gene transcription in response to low density lipoprotein free cholesterol

1997 • 256 citations

Transgenic Polyoma middle-T mice model premalignant mammary disease.

2001 • 250 citations

FORMATION OF ELABORATE NETWORKS OF T-SYSTEM TUBULES IN CULTURED SKELETAL MUSCLE WITH SPECIAL REFERENCE TO THE T-SYSTEM FORMATION

1968 • 249 citations

Accumulation of Caveolin in the Endoplasmic Reticulum Redirects the Protein to Lipid Storage Droplets

2001 • 242 citations

Caveolin mRNA levels are up-regulated by free cholesterol and down-regulated by oxysterols in fibroblast monolayers

1997 • 241 citations

Caveolin-2 Is Targeted to Lipid Droplets, a New “Membrane Domain” in the Cell

2001 • 238 citations

Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts

2003 • 229 citations

Invasion activating caveolin-1 mutation in human scirrhous breast cancers.

2001 • 225 citations

Caveolin-1 Expression Is Critical for Vascular Endothelial Growth Factor–Induced Ischemic Hindlimb Collateralization and Nitric Oxide–Mediated Angiogenesis

2004 • 224 citations

Platelet-derived growth factor activates mitogen-activated protein kinase in isolated caveolae

1997 • 221 citations

Genetic Ablation of Caveolin-1 Confers Protection Against Atherosclerosis

2003 • 217 citations

Glycosphingolipids Internalized via Caveolar-related Endocytosis Rapidly Merge with the Clathrin Pathway in Early Endosomes and Form Microdomains for Recycling

2003 • 216 citations

Reciprocal Regulation of Neu Tyrosine Kinase Activity and Caveolin-1 Protein Expression in Vitro and in Vivo

1998 • 215 citations

Caveolin-2 Localizes to the Golgi Complex but Redistributes to Plasma Membrane, Caveolae, and Rafts when Co-expressed with Caveolin-1

1999 • 212 citations

Expression of Caveolin-1 Is Required for the Transport of Caveolin-2 to the Plasma Membrane

1999 • 205 citations

Caveolin-1/3 Double-Knockout Mice Are Viable, but Lack Both Muscle and Non-Muscle Caveolae, and Develop a Severe Cardiomyopathic Phenotype

2002 • 204 citations

Identification of Caveolin-1 as a Fatty Acid Binding Protein

1999 • 200 citations

Caveolin forms a hetero-oligomeric protein complex that interacts with an apical GPI-linked protein: implications for the biogenesis of caveolae.

1993 • 197 citations

Cholesterol and Fatty Acids Regulate Dynamic Caveolin Trafficking through the Golgi Complex and between the Cell Surface and Lipid Bodies

2005 • 197 citations

Caveolin 1-Mediated Regulation of Receptor Tyrosine Kinase-Associated Phosphatidylinositol 3-Kinase Activity by Ceramide

2000 • 194 citations

Caveolin, cholesterol, and lipid bodies

2005 • 187 citations

Caveolinopathies

2004 • 184 citations

Caveolin-3 deficiency causes muscle degeneration in mice

2000 • 168 citations

Caveolin-1 Expression Enhances Endothelial Capillary Tubule Formation

2002 • 166 citations

Caveolin-1 Promotes Tumor Progression in an Autochthonous Mouse Model of Prostate Cancer

2005 • 164 citations

Absence of Caveolin-1 Sensitizes Mouse Skin to Carcinogen-Induced Epidermal Hyperplasia and Tumor Formation

2003 • 160 citations

Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis

2004 • 158 citations

Phenotypic Behavior of Caveolin-3 Mutations That Cause Autosomal Dominant Limb Girdle Muscular Dystrophy (LGMD-1C)

1999 • 158 citations

Relationships between caveolae and eNOS: everything in proximity and the proximity of everything

2002 • 155 citations

Transgenic overexpression of caveolin-3 in skeletal muscle fibers induces a Duchenne-like muscular dystrophy phenotype

2000 • 154 citations

Caveolin-1 Null (−/−) Mice Show Dramatic Reductions in Life Span

2003 • 150 citations

Caveolins and Cellular Cholesterol Balance

2000 • 145 citations

Loss of Caveolin-1 Gene Expression Accelerates the Development of Dysplastic Mammary Lesions in Tumor-Prone Transgenic Mice

2003 • 143 citations

Caveolin-1 Knockout Mice Show an Impaired Angiogenic Response to Exogenous Stimuli

2003 • 131 citations

Impairment of Caveolae Formation and T-System Disorganization in Human Muscular Dystrophy with Caveolin-3 Deficiency

2002 • 126 citations

Relationship between cholesterol trafficking and signaling in rafts and caveolae

2003 • 126 citations

RNA Genetics of Breast Cancer: Maspin as Paradigm

1994 • 123 citations

Caveolin-1 Inhibits Epidermal Growth Factor-stimulated Lamellipod Extension and Cell Migration in Metastatic Mammary Adenocarcinoma Cells (MTLn3)

2000 • 122 citations

A naturally occurring mutation of insulin receptor alanine 1134 impairs tyrosine kinase function and is associated with dominantly inherited insulin resistance.

1990 • 118 citations

Involvement of caveolin-1 in meiotic cell-cycle progression in Caenorhabditis elegans

1999 • 110 citations

Caveolin-1-deficient Mice Show Accelerated Mammary Gland Development During Pregnancy, Premature Lactation, and Hyperactivation of the Jak-2/STAT5a Signaling Cascade

2002 • 110 citations

Caveolin-3 knockout mice show increased adiposity and whole body insulin resistance, with ligand-induced insulin receptor instability in skeletal muscle

2005 • 106 citations

Increased Number of Caveolae and Caveolin-3 Overexpression in Duchenne Muscular Dystrophy

1999 • 103 citations

Limb-girdle Muscular Dystrophy (LGMD-1C) Mutants of Caveolin-3 Undergo Ubiquitination and Proteasomal Degradation

2000 • 97 citations

Insulin resistance in skeletal muscles of caveolin-3-null mice

2004 • 95 citations

Disruption of the Caveolin-1 Gene Impairs Renal Calcium Reabsorption and Leads to Hypercalciuria and Urolithiasis

2003 • 93 citations

Intracellular Retention of Glycosylphosphatidyl Inositol-Linked Proteins in Caveolin-Deficient Cells

2002 • 89 citations

Vectorial apical delivery and slow endocytosis of a glycolipid-anchored fusion protein in transfected MDCK cells.

1990 • 89 citations

Knockdown of Caveolin-1 by Antisense Oligonucleotides Impairs Angiogenesis in Vitro and in Vivo

2000 • 87 citations

Increased caveolin‐3 levels in mdx mouse muscles

1998 • 83 citations

Stabilization of Caveolin-1 by Cellular Cholesterol and Scavenger Receptor Class B Type I

2002 • 78 citations

Urogenital Alterations in Aged Male Caveolin-1 Knockout Mice

2004 • 76 citations

Modulation of Myoblast Fusion by Caveolin-3 in Dystrophic Skeletal Muscle Cells: Implications for Duchenne Muscular Dystrophy and Limb-Girdle Muscular Dystrophy-1C

2003 • 66 citations

The Role Of Caveolin-1 In Androgen Insensitive Prostate Cancer

2002 • 66 citations

Transgenic overexpression of caveolin-3 in the heart induces a cardiomyopathic phenotype

2003 • 64 citations

Overexpression of P104L mutant caveolin-3 in mice develops hypertrophic cardiomyopathy with enhanced contractility in association with increased endothelial nitric oxide synthase activity

2003 • 56 citations

Loss of caveolin-1 expression is associated with disruption of muscarinic cholinergic activities in the urinary bladder

2004 • 52 citations

Caveolin-1, a metastasis-related gene that promotes cell survival in prostate cancer.

1999 • 52 citations

Caveolin-1 Expression Is Essential for Proper Nonshivering Thermogenesis in Brown Adipose Tissue

2005 • 51 citations

A mutation (Trp1193?Leu1193) in the tyrosine kinase domain of the insulin receptor associated with type A syndrome of insulin resistance

1993 • 49 citations

Functional Properties of a Naturally Occurring Trp¹²⁰⁰→ Ser¹²⁰⁰Mutation of the Insulin Receptor

1990 • 48 citations

Phenotypic behavior of caveolin-3 R26Q, a mutant associated with hyperCKemia, distal myopathy, and rippling muscle disease

2003 • 45 citations

Prolactin Negatively Regulates Caveolin-1 Gene Expression in the Mammary Gland during Lactation, via a Ras-dependent Mechanism

2001 • 45 citations

Two naturally occurring mutations in the kinase domain of insulin receptor accelerate degradation of the insulin receptor and impair the kinase activity.

1994 • 40 citations

Phosphofructokinase Muscle-Specific Isoform Requires Caveolin-3 Expression for Plasma Membrane Recruitment and Caveolar Targeting

2003 • 29 citations