Assembly and mechanosensory function of focal contacts

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Cell Movement Is Guided by the Rigidity of the Substrate

2000 • 3,179 citations

Cell locomotion and focal adhesions are regulated by substrate flexibility

1997 • 2,930 citations

Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates

2001 • 2,089 citations

Rho GTPases and their effector proteins

2000 • 1,941 citations

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.

1996 • 1,614 citations

Signaling from Rho to the Actin Cytoskeleton Through Protein Kinases ROCK and LIM-kinase

1999 • 1,581 citations

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1999 • 1,558 citations

Focal Contacts as Mechanosensors

2001 • 1,390 citations

Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization

1998 • 1,263 citations

Signal transduction by G‐proteins, Rho‐kinase and protein phosphatase to smooth muscle and non‐muscle myosin II

2000 • 1,219 citations

Extracellular Matrix Rigidity Causes Strengthening of Integrin–Cytoskeleton Linkages

1997 • 1,218 citations

Molecular Basis of Mechanotransduction in Living Cells

2001 • 1,102 citations

Molecular complexity and dynamics of cell-matrix adhesions

2001 • 1,091 citations

Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

1999 • 1,048 citations

Cooperation between mDia1 and ROCK in Rho-induced actin reorganization

1999 • 884 citations

Rho-Kinase Phosphorylates COOH-terminal Threonines of Ezrin/Radixin/Moesin (ERM) Proteins and Regulates Their Head-to-Tail Association

1998 • 849 citations

p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin

1997 • 819 citations

Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex

1999 • 771 citations

Rho–Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells

2001 • 743 citations

Nascent Focal Adhesions Are Responsible for the Generation of Strong Propulsive Forces in Migrating Fibroblasts

2001 • 724 citations

Differential Localization of Rho Gtpases in Live Cells

2001 • 686 citations

Localized Rac Activation Dynamics Visualized in Living Cells

2000 • 667 citations

Distinct Roles of Rock (Rho-Kinase) and Mlck in Spatial Regulation of Mlc Phosphorylation for Assembly of Stress Fibers and Focal Adhesions in 3t3 Fibroblasts

2000 • 664 citations

Focal Adhesion Kinase: a regulator of focal adhesion dynamics and cell movement

2000 • 661 citations

Interplay between Rac and Rho in the control of substrate contact dynamics

1999 • 623 citations

Integrin-mediated Signals Regulated by Members of the Rho Family of GTPases

1998 • 615 citations

Dynamics and segregation of cell–matrix adhesions in cultured fibroblasts

2000 • 574 citations

Focal adhesions – the cytoskeletal connection

2000 • 569 citations

mDia mediates Rho-regulated formation and orientation of stable microtubules

2001 • 566 citations

IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling

2000 • 550 citations

Focal Adhesions: A Nexus for Intracellular Signaling and Cytoskeletal Dynamics

2000 • 511 citations

Rho-associated Kinase ROCK Activates LIM-kinase 1 by Phosphorylation at Threonine 508 within the Activation Loop

2000 • 507 citations

Regulation and Functions of Rho-Associated Kinase

2000 • 500 citations

Paxillin LD4 Motif Binds PAK and PIX through a Novel 95-kD Ankyrin Repeat, ARF–GAP Protein: A Role in Cytoskeletal Remodeling

1999 • 466 citations

Rho GTPases and their effector proteins

2000 • 461 citations

Integrin Dynamics and Matrix Assembly

2000 • 459 citations

Actin machinery: pushing the envelope

2000 • 458 citations

Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK

2000 • 454 citations

Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover

2000 • 454 citations

Microtubule Targeting of Substrate Contacts Promotes Their Relaxation and Dissociation

1999 • 452 citations

Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism

2000 • 429 citations

Cell to substratum contacts of chick fibroblasts and their relation to the microfilament system. a correlated interference-reflexion and high-voltage electron-microscope study

1978 • 409 citations

Focal adhesions: Structure and dynamics

2000 • 380 citations

Diaphanous-Related Formins Bridge Rho GTPase and Src Tyrosine Kinase Signaling

2000 • 379 citations

Involvement of microtubules in the control of adhesion-dependent signal transduction

1996 • 358 citations

Coordination of microtubules and the actin cytoskeleton by the Rho effector mDia1

2000 • 350 citations

Guidebook to the extracellular matrix, anchor, and adhesion proteins

1999 • 336 citations

Adhesions of fibroblasts to substratum during contact inhibition observed by interference reflection microscopy

1975 • 324 citations

Targeting, Capture, and Stabilization of Microtubules at Early Focal Adhesions

1998 • 323 citations

Identification of a Carboxyl-terminal Diaphanous-related Formin Homology Protein Autoregulatory Domain

2001 • 322 citations

Specific Activation of LIM kinase 2 via Phosphorylation of Threonine 505 by ROCK, a Rho-dependent Protein Kinase

2001 • 310 citations

A Role for P21-Activated Kinase in Endothelial Cell Migration

1999 • 295 citations

Rac recruits high-affinity integrin αvβ3 to lamellipodia in endothelial cell migration

2001 • 261 citations

p21-Activated protein kinase: a crucial component of morphological signaling?

1999 • 261 citations

The Mechanism of PAK Activation

2001 • 243 citations

Type Iα phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly

2000 • 230 citations

Actin-dependent Lamellipodia Formation and Microtubule-dependent Tail Retraction Control-directed Cell Migration

2000 • 226 citations

Caldesmon Inhibits Nonmuscle Cell Contractility and Interferes with the Formation of Focal Adhesions

1999 • 197 citations

Microtubule Depolymerization Induces Stress Fibers, Focal Adhesions, and DNA Synthesis via the GTP-Binding Protein Rho

1998 • 197 citations

Conditional Expression of a Truncated Fragment of Nonmuscle Myosin II-A Alters Cell Shape but Not Cytokinesis in HeLa Cells

2000 • 181 citations

Distinct Actions and Cooperative Roles of ROCK and mDia in Rho Small G Protein-induced Reorganization of the Actin Cytoskeleton in Madin–Darby Canine Kidney Cells

1999 • 165 citations

Functional analysis of the Drosophila Diaphanous FH protein in early embryonic development

2000 • 161 citations

LIM-kinase 2 induces formation of stress fibres, focal adhesions and membrane blebs, dependent on its activation by Rho-associated kinase-catalysed phosphorylation at threonine-505

2001 • 159 citations

Temporal and Spatial Distribution of Activated Pak1 in Fibroblasts

2000 • 157 citations

Cell-matrix contact structures

2001 • 156 citations

Control of Mitotic Spindle Position by the Saccharomyces cerevisiae Formin Bni1p

1999 • 154 citations

Dynamic Localization and Function of Bni1p at the Sites of Directed Growth in Saccharomyces cerevisiae

2001 • 153 citations

Effect of protein kinase inhibitor H‐7 on the contractility, integrity, and membrane anchorage of the microfilament system

1994 • 121 citations

Cytoskeleton cross‐talk during cell motility

1999 • 83 citations

Rho Small G-Protein-Dependent Binding of mDia to an Src Homology 3 Domain-Containing IRSp53/BAIAP2

2000 • 80 citations

Enforced polarisation and locomotion of fibroblasts lacking microtubules

2000 • 72 citations

Interaction of Paxillin with p21-activated Kinase (PAK)

2001 • 59 citations

Microtubule involvement in regulating cell contractility and adhesion-dependent signalling: a possible mechanism for polarization of cell motility.

1999 • 59 citations

Unravelling the extracellular matrix

1999 • 35 citations

The Structural Basis of Dynamic Cell Adhesion: Heads, Tails, and Allostery

2000 • 17 citations

Microtubule and actin-dependent movement of the formin cdc12p in fission yeast

2000 • 13 citations