A Rac switch regulates random versus directionally persistent cell migration

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Cell Migration: Integrating Signals from Front to Back

2003 • 4,755 citations

Rho GTPases in cell biology

2002 • 4,662 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Cellular Motility Driven by Assembly and Disassembly of Actin Filaments

2003 • 4,038 citations

Cell Migration: A Physically Integrated Molecular Process

1996 • 3,909 citations

Taking Cell-Matrix Adhesions to the Third Dimension

2001 • 2,940 citations

Rho and Rac Take Center Stage

2004 • 1,797 citations

Molecular Mechanisms Controlling Actin Filament Dynamics in Nonmuscle Cells

2000 • 1,471 citations

Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement

1999 • 1,452 citations

Cell migration: Rho GTPases lead the way

2003 • 1,412 citations

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

2004 • 1,085 citations

Integrin-Mediated Activation of Cdc42 Controls Cell Polarity in Migrating Astrocytes through PKCζ

2001 • 1,004 citations

Polarization of Chemoattractant Receptor Signaling During Neutrophil Chemotaxis

2000 • 892 citations

Cdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity

2003 • 823 citations

Chemotaxis: signalling the way forward

2004 • 690 citations

Localized Rac Activation Dynamics Visualized in Living Cells

2000 • 667 citations

Matrix-dependent Tiam1/Rac Signaling in Epithelial Cells Promotes Either Cell–Cell Adhesion or Cell Migration and Is Regulated by Phosphatidylinositol 3-Kinase

1998 • 667 citations

Activation of Rac and Cdc42 by Integrins Mediates Cell Spreading

1998 • 638 citations

Deficiency of the Hematopoietic Cell-Specific Rho Family GTPase Rac2 Is Characterized by Abnormalities in Neutrophil Function and Host Defense

1999 • 568 citations

Activation of Rac and Cdc42 Video Imaged by Fluorescent Resonance Energy Transfer-Based Single-Molecule Probes in the Membrane of Living Cells

2002 • 558 citations

IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling

2000 • 550 citations

A Role for Cdc42 in Macrophage Chemotaxis

1998 • 537 citations

Integrins Regulate Rac Targeting by Internalization of Membrane Domains

2004 • 533 citations

Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis

2003 • 484 citations

Roles of Rho-family GTPases in cell polarisation and directional migration

2003 • 467 citations

THE ROLE OF THREE CYTOPLASMIC FIBERS IN BHK-21 CELL MOTILITY

1971 • 453 citations

Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement

2004 • 358 citations

Cdc42, dynein, and dynactin regulate MTOC reorientation independent of Rho-regulated microtubule stabilization

2001 • 335 citations

The Locomotion of Mouse Fibroblasts in Tissue Culture

1970 • 328 citations

Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI

2002 • 326 citations

Cells into Organs: The Forces That Shape the Embryo

1970 • 318 citations

Rac1 Deletion in Mouse Neutrophils Has Selective Effects on Neutrophil Functions

2003 • 312 citations

Spatial Sensing in Fibroblasts Mediated by 3′ Phosphoinositides

2000 • 300 citations

Effect of colcemid on the locomotory behaviour of fibroblasts

1970 • 296 citations

Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass

2002 • 281 citations

Cell migration without a lamellipodium

2005 • 268 citations

Rho family proteins in cell adhesion and cell migration

2000 • 239 citations

Stroma-Derived Three-Dimensional Matrices Are Necessary and Sufficient to Promote Desmoplastic Differentiation of Normal Fibroblasts

2005 • 233 citations

Tyrosine 1101 of Tie2 Is the Major Site of Association of p85 and Is Required for Activation of Phosphatidylinositol 3-Kinase and Akt

1998 • 222 citations

An α4 integrin–paxillin–Arf-GAP complex restricts Rac activation to the leading edge of migrating cells

2005 • 206 citations

Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compass

2004 • 198 citations

Cell migration as a five-step cycle.

1999 • 193 citations

Integrins control motile strategy through a Rho–cofilin pathway

2005 • 191 citations

A Local Coupling Model and Compass Parameter for Eukaryotic Chemotaxis

2005 • 191 citations

A role for cytoplasmic dynein and LIS1 in directed cell movement

2003 • 179 citations

Cell Migration in Development and Disease

2002 • 157 citations

Motility and invasion are differentially modulated by Rho family GTPases

2000 • 150 citations

Role of Rac in controlling the actin cytoskeleton and chemotaxis in motile cells

2000 • 144 citations

Modulation of Rac Localization and Function by Dynamin

2003 • 139 citations

Involvement of Phosphoinositide 3-Kinase γ, Rac, and PAK Signaling in Chemokine-induced Macrophage Migration

2004 • 98 citations

Studying actin-dependent processes in tissue culture

2002 • 97 citations

Specific β1 Integrin Site Selectively Regulates Akt/Protein Kinase B Signaling via Local Activation of Protein Phosphatase 2A

2003 • 89 citations

Vascular Endothelial Growth Factor Causes Translocation of p47 to Membrane Ruffles through WAVE1

2003 • 83 citations

Rac2 Specificity in Macrophage Integrin Signaling

2003 • 47 citations

Glycogen synthase kinase-3 regulates cytoskeleton and translocation of Rac1 in long cellular extensions of human keratinocytes

2003 • 35 citations

Preparation of Extracellular Matrices Produced by Cultured Fibroblasts

2002 • 22 citations