Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion

The polycomb group protein EZH2 is involved in progression of prostate cancer

2002 • 2,600 citations

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1995 • 1,810 citations

Genomic analysis of metastasis reveals an essential role for RhoC

2000 • 1,449 citations

Compensation mechanism in tumor cell migration

2003 • 1,360 citations

FAK–Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly

2004 • 1,330 citations

Regulation of Cell Motility by Mitogen-activated Protein Kinase

1997 • 1,238 citations

Inhibition of Cell Migration, Spreading, and Focal Adhesions by Tumor Suppressor PTEN

1998 • 1,215 citations

FAK integrates growth-factor and integrin signals to promote cell migration

2000 • 1,215 citations

Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis

2003 • 1,109 citations

Molecular complexity and dynamics of cell-matrix adhesions

2001 • 1,091 citations

Synergistic Roles for Receptor Occupancy and Aggregation in Integrin Transmembrane Function

1995 • 900 citations

Src family kinases are required for integrin but not PDGFR signal transduction

1999 • 733 citations

Src in cancer: deregulation and consequences for cell behaviour

2002 • 679 citations

Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells

2003 • 658 citations

Differential regulation of cell motility and invasion by FAK

2003 • 531 citations

Paxillin: a focal adhesion-associated adaptor protein

2001 • 520 citations

Identification of p130Cas as a Mediator of Focal Adhesion Kinase–promoted Cell Migration

1998 • 501 citations

JNK phosphorylates paxillin and regulates cell migration

2003 • 461 citations

Novel tyrosine kinase substrates from Rous sarcoma virus-transformed cells are present in the membrane skeleton.

1989 • 457 citations

Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells

2001 • 455 citations

Microtubule Targeting of Substrate Contacts Promotes Their Relaxation and Dissociation

1999 • 452 citations

Protein-tyrosine Phosphatase Shp-2 Regulates Cell Spreading, Migration, and Focal Adhesion

1998 • 390 citations

Cutting to the chase: calpain proteases in cell motility

2002 • 386 citations

Regulation of Cell Migration by the Calcium-dependent Protease Calpain

1997 • 386 citations

Marching at the front and dragging behind

2001 • 358 citations

Active ERK/MAP kinase is targeted to newly forming cell-matrix adhesions by integrin engagement and v-Src

2000 • 336 citations

c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism.

1995 • 324 citations

Development of anticancer drugs targeting the MAP kinase pathway

2000 • 322 citations

The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility

1998 • 290 citations

Colocalization of calcium-dependent protease II and one of its substrates at sites of cell adhesion

1987 • 274 citations

Epidermal Growth Factor Receptor Activation of Calpain Is Required for Fibroblast Motility and Occurs via an ERK/MAP Kinase Signaling Pathway

2000 • 272 citations

Epidermal Growth Factor Activates m-Calpain (Calpain II), at Least in Part, by Extracellular Signal-Regulated Kinase-Mediated Phosphorylation

2004 • 265 citations

Calpain Regulates Actin Remodeling during Cell Spreading

1998 • 264 citations

Reduced Cell Migration and Disruption of the Actin Cytoskeleton in Calpain-deficient Embryonic Fibroblasts

2001 • 250 citations

Degraded Collagen Fragments Promote Rapid Disassembly of Smooth Muscle Focal Adhesions That Correlates with Cleavage of Pp125FAK, Paxillin, and Talin

1999 • 249 citations

Calpain Cleavage Promotes Talin Binding to the β3Integrin Cytoplasmic Domain

2001 • 219 citations

Microtubules meet substrate adhesions to arrange cell polarity

2003 • 212 citations

Src-catalyzed Phosphorylation of c-Cbl Leads to the Interdependent Ubiquitination of Both Proteins

2001 • 212 citations

Regulation of focal complex composition and disassembly by the calcium-dependent protease calpain

2002 • 206 citations

A Novel Role for FAK as a Protease-Targeting Adaptor Protein

2003 • 194 citations

Direct Interaction of Focal Adhesion Kinase with p190RhoGEF

2003 • 184 citations

FRNK blocks v-Src-stimulated invasion and experimental metastases without effects on cell motility or growth

2002 • 184 citations

BCR/ABL induces multiple abnormalities of cytoskeletal function.

1997 • 174 citations

Role of Rho-family proteins in cell adhesion and cancer

2003 • 171 citations

Focal adhesion kinase (pp125FAK) cleavage and regulation by calpain

1996 • 167 citations

Increased tyrosine phosphorylation of focal adhesion proteins in myeloid cell lines expressing p210BCR/ABL.

1995 • 148 citations

Impaired Integrin-mediated Adhesion and Signaling in Fibroblasts Expressing a Dominant-negative Mutant PTP1B

1998 • 145 citations

Src Catalytic but Not Scaffolding Function Is Needed for Integrin-Regulated Tyrosine Phosphorylation, Cell Migration, and Cell Spreading

2002 • 144 citations

Tyrosine phosphorylation and cytoskeletal tension regulate the release of fibroblast adhesions.

1995 • 142 citations

Regulation of Fibroblast Motility by the Protein Tyrosine Phosphatase PTP-PEST

1999 • 136 citations

Cleavage of Focal Adhesion Kinase by Different Proteases during Src-regulated Transformation and Apoptosis

2001 • 131 citations

MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts

2003 • 125 citations

Calpain Mediates Integrin-induced Signaling at a Point Upstream of Rho Family Members

1999 • 124 citations

Ubiquitin-dependent degradation of active Src

1999 • 122 citations

Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway

1998 • 117 citations

Focal Adhesion Kinase Facilitates Platelet-derived Growth Factor-BB-stimulated ERK2 Activation Required for Chemotaxis Migration of Vascular Smooth Muscle Cells

2000 • 115 citations

pp60src is an endogenous substrate for calpain in human blood platelets

1993 • 114 citations

Calpain-2 as a target for limiting prostate cancer invasion.

2003 • 111 citations

v-Src-Induced Modulation of the Calpain-Calpastatin Proteolytic System Regulates Transformation

2002 • 109 citations

RNF5, a RING Finger Protein That Regulates Cell Motility by Targeting Paxillin Ubiquitination and Altered Localization

2003 • 109 citations

Direct, dynamic assessment of cell‐matrix interactions inside fibrillar collagen lattices

2003 • 109 citations

Live-cell monitoring of tyrosine phosphorylation in focal adhesions following microtubule disruption

2003 • 105 citations

Evidence That β3 Integrin-Induced Rac Activation Involves the Calpain-Dependent Formation of Integrin Clusters That Are Distinct from the Focal Complexes and Focal Adhesions That Form as Rac and Rhoa Become Active

2000 • 102 citations

Tyrosine Phosphatase-ε Activates Src and Supports the Transformed Phenotype of Neu-induced Mammary Tumor Cells

2003 • 99 citations

Calpain Cleaves RhoA Generating a Dominant-negative Form That Inhibits Integrin-induced Actin Filament Assembly and Cell Spreading

2002 • 98 citations

MEK Mediates v-Src-induced Disruption of the Actin Cytoskeleton via Inactivation of the Rho-ROCK-LIM Kinase Pathway

2002 • 97 citations

Tyrosine Phosphorylation Regulates Alpha II Spectrin Cleavage by Calpain

2002 • 93 citations

Targeting Membrane-localized Focal Adhesion Kinase to Focal Adhesions

2003 • 89 citations

Differential activation of ERKs to focal adhesions by PKC ε is required for PMA-induced adhesion and migration of human glioma cells

2001 • 85 citations

Proteolysis of Platelet Cortactin by Calpain

1997 • 74 citations

Expression of calpain I messenger RNA in human renal cell carcinoma: Correlation with lymph node metastasis and histological type

1999 • 66 citations

The Role of Mitogen-Activated Protein Kinase Activation within Focal Adhesions in Chemotaxis toward FGF-2 by Murine Brain Capillary Endothelial Cells

2001 • 66 citations

In vitro proteolysis of brain spectrin by calpain I inhibits association of spectrin with ankyrin-independent membrane binding site(s).

1991 • 61 citations

Focal adhesion kinase as a potential target in oncology

2003 • 60 citations

Activated c-Abl is degraded by the ubiquitin-dependent proteasome pathway

2001 • 60 citations

Src-mediated Tyrosine Phosphorylation of NR2 Subunits of N-Methyl-d-Aspartate Receptors Protects from Calpain-mediated Truncation of Their C-terminal Domains

2000 • 51 citations

WASP and N-WASP in human platelets differ in sensitivity to protease calpain

2001 • 45 citations

Deletion of the Src Homology 3 Domain and C-terminal Proline-rich Sequences in Bcr-Abl Prevents Abl Interactor 2 Degradation and Spontaneous Cell Migration and Impairs Leukemogenesis

2001 • 40 citations

Calpain is required for MMP-2 and u-PA expression in SV40 large T-antigen-immortalized cells

2002 • 25 citations