Leukocyte polarization in cell migration and immune interactions

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Cell Migration: A Physically Integrated Molecular Process

1996 • 3,909 citations

Chemokines — Chemotactic Cytokines That Mediate Inflammation

1998 • 3,660 citations

Lymphocyte Homing and Homeostasis

1996 • 2,934 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Chemokines and leukocyte traffic

1998 • 2,755 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

Human Chemokines: An Update

1997 • 2,235 citations

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

1988 • 2,137 citations

Properties of the Novel Proinflammatory Supergene "Intercrine" Cytokine Family

1991 • 1,864 citations

Actin-Based Cell Motility and Cell Locomotion

1996 • 1,536 citations

Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness

1997 • 1,400 citations

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.

1992 • 1,330 citations

Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase

1997 • 1,085 citations

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.

1996 • 1,045 citations

Origins of Cell Polarity

1996 • 1,024 citations

On the Crawling of Animal Cells

1993 • 1,020 citations

Wiskott–Aldrich Syndrome Protein, a Novel Effector for the GTPase CDC42Hs, Is Implicated in Actin Polymerization

1996 • 873 citations

Rho-Kinase Phosphorylates COOH-terminal Threonines of Ezrin/Radixin/Moesin (ERM) Proteins and Regulates Their Head-to-Tail Association

1998 • 849 citations

ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons.

1994 • 790 citations

Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K

1997 • 746 citations

Mammalian Membrane-bound Adenylyl Cyclases

1995 • 722 citations

A Novel Adaptor Protein Orchestrates Receptor Patterning and Cytoskeletal Polarity in T-Cell Contacts

1998 • 708 citations

Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

1997 • 687 citations

Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

1995 • 665 citations

Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP

1998 • 656 citations

Bni1p, a Yeast Formin Linking Cdc42p and the Actin Cytoskeleton During Polarized Morphogenesis

1997 • 654 citations

Unconventional Myosins in Cell Movement, Membrane Traffic, and Signal Transduction

1998 • 649 citations

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

1994 • 647 citations

Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway.

1996 • 601 citations

Ezrin/Radixin/Moesin (ERM) Proteins Bind to a Positively Charged Amino Acid Cluster in the Juxta-Membrane Cytoplasmic Domain of CD44, CD43, and ICAM-2

1998 • 592 citations

Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes.

1996 • 560 citations

Selective modulation of protein kinase C-Θ during T-cell activation

1997 • 558 citations

Ca2+- and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils

1995 • 555 citations

A Role for Cdc42 in Macrophage Chemotaxis

1998 • 537 citations

Multistep Navigation and the Combinatorial Control of Leukocyte Chemotaxis

1997 • 531 citations

Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton.

1995 • 528 citations

Focal adhesion kinase and associated proteins

1994 • 525 citations

Phosphoinositides and Calcium as Regulators of Cellular Actin Assembly and Disassembly

1994 • 524 citations

Adhesion in cell migration

1995 • 520 citations

Chemoattractant signaling and leukocyte activation

1995 • 510 citations

Role of Rho in Chemoattractant-Activated Leukocyte Adhesion Through Integrins

1996 • 494 citations

The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes.

1990 • 480 citations

Interleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T lymphocytes.

1996 • 443 citations

Regulation of chemotaxis by the platelet-derived growth factor receptor-β

1994 • 441 citations

Polarity of T Cell Shape, Motility, and Sensitivity to Antigen

1996 • 438 citations

Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages

1997 • 415 citations

Chemokines and T Lymphocytes

1998 • 403 citations

Signal Transduction Due to HIV-1 Envelope Interactions with Chemokine Receptors CXCR4 or CCR5

1997 • 394 citations

Regulation of Cell Migration by the Calcium-dependent Protease Calpain

1997 • 386 citations

Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42.

1995 • 386 citations

Antigen receptor engagement delivers a stop signal to migrating T lymphocytes

1997 • 386 citations

ERM (ezrin/radixin/moesin) family: from cytoskeleton to signal transduction

1997 • 363 citations

Protein kinase C involvement in focal adhesion formation

1992 • 361 citations

A New Member of the Rho Family, Rnd1, Promotes Disassembly of Actin Filament Structures and Loss of Cell Adhesion

1998 • 349 citations

Rho1p, a Yeast Protein at the Interface Between Cell Polarization and Morphogenesis

1996 • 329 citations

The Wiskott-Aldrich syndrome: studies of lymphocytes, granulocytes, and platelets

1980 • 327 citations

Cell motility and chemotaxis in Dictyostelium amebae lacking myosin heavy chain

1988 • 326 citations

Phosphorylation of microtubule-associated proteins regulates their interaction with actin filaments.

1983 • 319 citations

The kinetics of chemotactic peptide-induced change in F-actin content, F-actin distribution, and the shape of neutrophils.

1985 • 319 citations

Heterotrimeric G proteins

1996 • 318 citations

Chemokine Receptors: Keys to AIDS Pathogenesis?

1998 • 310 citations

Ezrin is a cyclic AMP-dependent protein kinase anchoring protein

1997 • 309 citations

Rho- and Rac-dependent Assembly of Focal Adhesion Complexes and Actin Filaments in Permeabilized Fibroblasts: An Essential Role for Ezrin/Radixin/Moesin Proteins

1997 • 303 citations

Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3' kinase.

1994 • 303 citations

Cell Biology of Cytotoxic and Helper T Cell Functions: Immunofluorescence Microscopic Studies of Single Cells and Cell Couples

1989 • 296 citations

Calcium Gradients Underlying Polarization and Chemotaxis of Eosinophils

1991 • 283 citations

Capping of surface receptors and concomitant cortical tension are generated by conventional myosin

1989 • 274 citations

Chemokines regulate cellular polarization and adhesion receptor redistribution during lymphocyte interaction with endothelium and extracellular matrix. Involvement of cAMP signaling pathway.

1995 • 265 citations

RAC Regulation of Actin Polymerization and Proliferation by a Pathway Distinct from Jun Kinase

1996 • 264 citations

Physical and biochemical regulation of integrin release during rear detachment of migrating cells

1998 • 260 citations

Rho Guanosine Triphosphatase Mediates the Selective Stabilization of Microtubules Induced by Lysophosphatidic Acid

1998 • 257 citations

A mechanical function of myosin II in cell motility

1995 • 254 citations

Role of a New Rho Family Member in Cell Migration and Axon Guidance in C. elegans

1997 • 251 citations

Cytoskeletal Polarization of T Cells Is Regulated by an Immunoreceptor Tyrosine-based Activation Motif–dependent Mechanism

1998 • 247 citations

Moesin Interacts with the Cytoplasmic Region of Intercellular Adhesion Molecule-3 and Is Redistributed to the Uropod of T Lymphocytes during Cell Polarization

1997 • 238 citations

Dynamic Distribution of Chemoattractant Receptors in Living Cells During Chemotaxis and Persistent Stimulation

1997 • 234 citations

ICAM-2 redistributed by ezrin as a target for killer cells

1996 • 233 citations

Synthetic lethality screen identifies a novel yeast myosin I gene (MYO5): myosin I proteins are required for polarization of the actin cytoskeleton.

1996 • 229 citations

Inhibition of PMA-induced, LFA-1-dependent lymphocyte aggregation by ADP ribosylation of the small molecular weight GTP binding protein, rho.

1993 • 223 citations

Polarization of Chemokine Receptors to the Leading Edge during Lymphocyte Chemotaxis

1997 • 219 citations

CD4+ T lymphocytes migrating in three-dimensional collagen lattices lack focal adhesions and utilize β1 integrin-independent strategies for polarization, interaction with collagen fibers and locomotion

1998 • 213 citations

Protein Kinase C-θ Phosphorylation of Moesin in the Actin-binding Sequence

1998 • 213 citations

Association of the Myosin-binding Subunit of Myosin Phosphatase and Moesin: Dual Regulation of Moesin Phosphorylation by Rho-associated Kinase and Myosin Phosphatase

1998 • 210 citations

The ezrin protein family: membrane-cytoskeleton interactions and disease associations

1997 • 205 citations

Inhibition of Neutrophil Chemokinesis on Vitronectin by Inhibitors of Calcineurin

1992 • 200 citations

CDC42 and Rac1 control different actin-dependent processes in the Drosophila wing disc epithelium.

1995 • 190 citations

Production of chemokines, interleukin-8 and monocyte chemoattractant protein-1, during monocyte: endothelial cell interactions

1995 • 184 citations

Patterns of elevated free calcium and calmodulin activation in living cells

1992 • 177 citations

ICAM-3 interacts with LFA-1 and regulates the LFA-1/ICAM-1 cell adhesion pathway.

1993 • 170 citations

Small splenic B cells that bind to antigen-specific T helper (Th) cells and face the site of cytokine production in the Th cells selectively proliferate: immunofluorescence microscopic studies of Th-B antigen-presenting cell interactions.

1994 • 168 citations

Moving Membrane up to the Front of Migrating Cells

1996 • 167 citations

Signal Transduction and Ligand Specificity of the Human Monocyte Chemoattractant Protein-1 Receptor in Transfected Embryonic Kidney Cells

1995 • 165 citations

Inhibition of chemotactic peptide-induced neutrophil adhesion to vascular endothelium by cAMP modulators.

1995 • 152 citations

Concentration of an integral membrane protein, CD43 (leukosialin, sialophorin), in the cleavage furrow through the interaction of its cytoplasmic domain with actin-based cytoskeletons.

1993 • 148 citations

RANTES-activated human T lymphocytes. A role for phosphoinositide 3-kinase.

1995 • 147 citations

Relative distribution of actin, myosin I, and myosin II during the wound healing response of fibroblasts.

1993 • 146 citations

T cell lines characterize events in the pathogenesis of the Wiskott-Aldrich syndrome.

1992 • 141 citations

Cytokinesis arrest and redistribution of actin-cytoskeleton regulatory components in cells expressing the Rho GTPase CDC42Hs

1996 • 141 citations

Identification of a New Pyk2 Isoform Implicated in Chemokine and Antigen Receptor Signaling

1998 • 137 citations

ICAMs Redistributed by Chemokines to Cellular Uropods as a Mechanism for Recruitment of T Lymphocytes

1997 • 136 citations

Urokinase-type plasminogen activator receptor reversibly dissociates from complement receptor type 3 (alpha M beta 2' CD11b/CD18) during neutrophil polarization.

1996 • 134 citations

Activation of polymorphonuclear leukocytes reduces their adhesion to P-selectin and causes redistribution of ligands for P-selectin on their surfaces.

1995 • 131 citations

Microtubule retraction into the uropod and its role in T cell polarization and motility.

1997 • 124 citations

Relationship of F-actin distribution to development of polar shape in human polymorphonuclear neutrophils

1992 • 118 citations

Roles of Chemokines and Receptor Polarization in NK-Target Cell Interactions

1998 • 102 citations

The locomotor capacity of human lymphocytes and its enhancement by cell growth.

1986 • 94 citations

Asymmetric distribution of the chemotactic peptide receptor on polymorphonuclear leukocytes.

1984 • 90 citations

Location of actin, myosin, and microtubular structures during directed locomotion of Dictyostelium amebae.

1984 • 90 citations

Generation of cell polarity in yeast

1996 • 89 citations

ICAM-3 regulates lymphocyte morphology and integrin-mediated T cell interaction with endothelial cell and extracellular matrix ligands.

1994 • 86 citations

Stimulation of CD28 with B7-2 promotes focal adhesion-like cell contacts where Rho family small G proteins accumulate in T cells.

1998 • 84 citations

Networking Rho Family GTPases in Lymphocytes

1998 • 82 citations

A Calcium-dependent Tyrosine Kinase Splice Variant in Human Monocytes

1998 • 79 citations

Syn-capping of human T lymphocyte adhesion/activation molecules and their redistribution during interaction with endothelial cells

1993 • 69 citations

Differential requirement of protein tyrosine kinases and protein kinase C in the regulation of T cell locomotion in three-dimensional collagen matrices.

1997 • 69 citations

Mediation of chemoattractant-induced changes in [Ca2+]i and cell shape, polarity, and locomotion by InsP3, DAG, and protein kinase C in newt eosinophils.

1994 • 64 citations

Cell Crawling: First the Motor, Now the Transmission

1998 • 59 citations

Involvement of phosphoinositide 3-kinase and Rac in membrane ruffling induced by IL-2 in T cells

1998 • 57 citations

Mobility of the human T lymphocyte surface molecules CD3, CD4, and CD8: regulation by a cAMP-dependent pathway.

1988 • 57 citations

Studies of chemotactic factor-induced polarity in human neutrophils : Lipid mobility, receptor distribution and the time-sequence of polarization

1991 • 53 citations

Functional molecular complexes of human N-formyl chemoattractant receptors and actin.

1993 • 43 citations

Chemoattractant-induced changes in surface expression and redistribution of a functional ligand for P-selectin on neutrophils

1996 • 39 citations

Locomotory phenotypes of human tumor cell lines and T lymphocytes in a three-dimensional collagen lattice

1997 • 37 citations

Characterization of the Novel Focal Adhesion Kinase RAFTK in Hematopoietic Cells

1997 • 29 citations

Macrophage inflammatory protein-1 alpha enhances growth factor-stimulated phosphatidylcholine metabolism and increases cAMP levels in the human growth factor-dependent cell line M07e, events associated with growth suppression.

1995 • 26 citations