Src Kinase Regulates the Activation of a Novel FGD-1-related Cdc42 Guanine Nucleotide Exchange Factor in the Signaling Pathway from the Endothelin A Receptor to JNK

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Small GTP-Binding Proteins

2001 • 2,449 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

Guanine nucleotide exchange factors for Rho GTPases: turning on the switch

2002 • 1,225 citations

Rho GTPases and cell migration

2001 • 1,170 citations

STRUCTURE AND FUNCTION OF G PROTEIN-COUPLED RECEPTORS

1994 • 1,070 citations

Regulation of the Cytoskeleton and Cell Adhesion by the Rho Family GTPases in Mammalian Cells

1999 • 1,015 citations

The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades

1998 • 819 citations

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav

1998 • 798 citations

Ras and Rho GTPases

2000 • 779 citations

Direct Stimulation of the Guanine Nucleotide Exchange Activity of p115 RhoGEF by Gα ₁₃

1998 • 765 citations

Bidirectional signaling between the cytoskeleton and integrins

1999 • 765 citations

Characterization of Rac and Cdc42 Activation in Chemoattractant-stimulated Human Neutrophils Using a Novel Assay for Active GTPases

1999 • 765 citations

Regulation of tyrosine kinase cascades by G-protein-coupled receptors

1999 • 688 citations

Regulatory and Signaling Properties of the Vav Family

2000 • 513 citations

Cortical Actin Organization: Lessons from ERM (Ezrin/Radixin/Moesin) Proteins

1999 • 464 citations

P-Rex1, a PtdIns(3,4,5)P3- and Gβγ-Regulated Guanine-Nucleotide Exchange Factor for Rac

2002 • 460 citations

Coupling of Ras and Rac Guanosine Triphosphatases Through the Ras Exchanger Sos

1998 • 452 citations

A Novel PDZ Domain Containing Guanine Nucleotide Exchange Factor Links Heterotrimeric G Proteins to Rho

1999 • 386 citations

Structural Basis for Relief of Autoinhibition of the Dbl Homology Domain of Proto-Oncogene Vav by Tyrosine Phosphorylation

2000 • 381 citations

Regulation of cortical structure by the ezrin-radixin-moesin protein family

1999 • 365 citations

The Role of Rho in G Protein-Coupled Receptor Signal Transduction

2000 • 345 citations

Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product.

1994 • 314 citations

Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates

1992 • 306 citations

Biological and Regulatory Properties of Vav-3, a New Member of the Vav Family of Oncoproteins

1999 • 268 citations

AKAP-Lbc Anchors Protein Kinase A and Nucleates Gα12-selective Rho-mediated Stress Fiber Formation

2001 • 229 citations

Leukemia‐associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G₁₂ family to Rho

2000 • 224 citations

Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: Evidence for its fusion with MLL in acute myeloid leukemia

2000 • 223 citations

Gα12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF

2003 • 208 citations

Expression Cloning of lfc, a Novel Oncogene with Structural Similarities to Guanine Nucleotide Exchange Factors and to the Regulatory Region of Protein Kinase C

1995 • 188 citations

Control of Intramolecular Interactions between the Pleckstrin Homology and Dbl Homology Domains of Vav and Sos1 Regulates Rac Binding

2000 • 185 citations

Cytoskeletal Reorganization by G Protein-Coupled Receptors Is Dependent on Phosphoinositide 3-Kinase γ, a Rac Guanosine Exchange Factor, and Rac

1998 • 181 citations

NMR Structure and Mutagenesis of the N-Terminal Dbl Homology Domain of the Nucleotide Exchange Factor Trio

1998 • 171 citations

Accumulation of GTP-bound RhoA during Cytokinesis and a Critical Role of ECT2 in This Accumulation

2000 • 163 citations

Potent Activation of RhoA by Gαq and Gq-coupled Receptors

2002 • 160 citations

The Faciogenital Dysplasia Gene Product FGD1 Functions as a Cdc42Hs-specific Guanine-Nucleotide Exchange Factor

1996 • 158 citations

Can we infer peptide recognition specificity mediated by SH3 domains?

2002 • 148 citations

Leukemia-associated Rho Guanine Nucleotide Exchange Factor, a Dbl Family Protein Found Mutated in Leukemia, Causes Transformation by Activation of RhoA

2001 • 124 citations

Oncogenic activity of Tiam1 and Rac1 in NIH3T3 cells.

1995 • 124 citations

Mechanisms for Reversible Regulation between G13 and Rho Exchange Factors

2002 • 122 citations

Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF

2001 • 110 citations

G Protein-Coupled Receptors: Functional and Mechanistic Insights Through Altered Gene Expression

1998 • 106 citations

A Rho Exchange Factor Mediates Thrombin and Gα12-induced Cytoskeletal Responses

1999 • 103 citations

Rho GTPase-dependent transformation by G protein-coupled receptors

2001 • 90 citations

Frabin, a Novel FGD1-related Actin Filament-binding Protein Capable of Changing Cell Shape and Activating c-Jun N-terminal Kinase

1998 • 83 citations

G13α-mediated PYK2 Activation

2000 • 81 citations

Identification of Potential Mechanisms for Regulation of p115 RhoGEF through Analysis of Endogenous and Mutant Forms of the Exchange Factor

2001 • 75 citations

A Novel FERM Domain Including Guanine Nucleotide Exchange Factor Is Involved in Rac Signaling and Regulates Neurite Remodeling

2002 • 74 citations

Induction of Rac-Guanine Nucleotide Exchange Activity of Ras-GRF1/CDC25Mm following Phosphorylation by the Nonreceptor Tyrosine Kinase Src

2000 • 68 citations

Distinct roles for DH and PH domains in the Lbc oncogene

1997 • 66 citations

Differential Regulation of Mitogen-activated Protein Kinase Kinase 4 (MKK4) and 7 (MKK7) by Signaling from G Protein βγ Subunit in Human Embryonal Kidney 293 Cells

1999 • 60 citations

Gi-dependent Activation of c-Jun N-terminal Kinase in Human Embryonal Kidney 293 Cells

2000 • 54 citations

Subtype-specific Trafficking of Endothelin Receptors

2000 • 50 citations

Functions of a Rho-specific Guanine Nucleotide Exchange Factor in Neurite Retraction

2000 • 45 citations

Isolation, characterization, and mapping of the mouse Fgd3 gene, a new Faciogenital Dysplasia (FGD1; Aarskog Syndrome) gene homologue

2000 • 44 citations

Molecular Cloning and Characterization of CDEP, a Novel Human Protein Containing the Ezrin-like Domain of the Band 4.1 Superfamily and the Dbl Homology Domain of Rho Guanine Nucleotide Exchange Factors

1997 • 39 citations

Endothelin suppresses cell migration via the JNK signaling pathway in a manner dependent upon Src kinase, Rac1, and Cdc42

2002 • 33 citations

β2-Adrenergic Receptor/Cyclic Adenosine Monophosphate (cAMP) Leads to JNK Activation through Rho Family Small GTPases

2001 • 21 citations

Chondrocyte-derived ezrin-like domain containing protein (CDEP), a rho guanine nucleotide exchange factor, is inducible in chondrocytes by parathyroid hormone and cyclic AMP and has transforming activity in NIH3T3 Cells

2001 • 17 citations

Role of Dbl's big sister in the anti-mitogenic pathway from α1B-adrenergic receptor to c-Jun N-terminal kinase

2002 • 11 citations

Gαq-Dependent Activation of Mitogen-Activated Protein Kinase Kinase 4/c-Jun N-Terminal Kinase Cascade

2001 • 11 citations