Rac1 Function Is Required for Src-induced Transformation

CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES

1997 • 2,470 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1

1999 • 1,282 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

Nucleotide sequence of rous sarcoma virus

1983 • 901 citations

Role of Src expression and activation in human cancer

2000 • 832 citations

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1997 • 769 citations

SU6656, a Selective Src Family Kinase Inhibitor, Used To Probe Growth Factor Signaling

2000 • 577 citations

Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins

1994 • 518 citations

Regulatory and Signaling Properties of the Vav Family

2000 • 513 citations

Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis

2001 • 487 citations

The insulinomimetic agents H2O2 and vanadate stimulate protein tyrosine phosphorylation in intact cells.

1990 • 440 citations

Dbl family guanine nucleotide exchange factors

2001 • 414 citations

Analysis of receptor signaling pathways by mass spectrometry: Identification of Vav-2 as a substrate of the epidermal and platelet-derived growth factor receptors

2000 • 409 citations

Src Family Tyrosine Kinases and Growth Factor Signaling

2000 • 391 citations

Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours

2002 • 388 citations

Integration of Rac-dependent Regulation of Cyclin D1 Transcription through a Nuclear Factor-κB-dependent Pathway

1999 • 289 citations

Rho GTPases in transformation and metastasis

2002 • 274 citations

c-Src Is Required for Oxidative Stress-mediated Activation of Big Mitogen-activated Protein Kinase 1 (BMK1)

1997 • 270 citations

Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2

1998 • 265 citations

Differences between the Ribonucleic Acids of Transforming and Nontransforming Avian Tumor Viruses

1970 • 262 citations

Requirement for Ras/Rac1-Mediated p38 and c-Jun N-Terminal Kinase Signaling in Stat3 Transcriptional Activity Induced by the Src Oncoprotein

1999 • 259 citations

Vav2 Is an Activator of Cdc42, Rac1, and RhoA

2000 • 250 citations

Signaling from G Protein-coupled Receptors to c-Jun Kinase Involves βγ Subunits of Heterotrimeric G Proteins Acting on a Ras and Rac1-dependent Pathway

1996 • 246 citations

Nucleotide sequences related to the transforming gene of avian sarcoma virus are present in DNA of uninfected vertebrates.

1978 • 245 citations

pp60v- Induction of Cyclin D1 Requires Collaborative Interactions between the Extracellular Signal-regulated Kinase, p38, and Jun Kinase Pathways

1999 • 227 citations

Vav2 Activates Rac1, Cdc42, and RhoA Downstream from Growth Factor Receptors but Not β1 Integrins

2000 • 191 citations

Involvement of Tyrosine Phosphorylation and Protein Kinase C in the Activation of Phospholipase D by H2O2 in Swiss 3T3 Fibroblasts

1998 • 171 citations

Ca2+/Calmodulin-dependent Protein Kinase II Regulates Tiam1 by Reversible Protein Phosphorylation

1999 • 169 citations

Regulation of gene expression by the small GTPase Rho through the ERK6 (p38γ) MAP kinase pathway

2001 • 167 citations

Potent Activation of RhoA by Gαq and Gq-coupled Receptors

2002 • 160 citations

Regulation of G Protein-linked Guanine Nucleotide Exchange Factors for Rho, PDZ-RhoGEF, and LARG by Tyrosine Phosphorylation

2002 • 155 citations

Transmission of a Malignant New Growth by Means of a Cell-Free Filtrate

1983 • 143 citations

Regulation of c-myc expression by PDGF through Rho GTPases

2001 • 137 citations

Ankyrin–Tiam1 Interaction Promotes Rac1 Signaling and Metastatic Breast Tumor Cell Invasion and Migration

2000 • 131 citations

Oncogenic activity of Tiam1 and Rac1 in NIH3T3 cells.

1995 • 124 citations

Regulation of Rb and E2F by signal transduction cascades: divergent effects of JNK1 and p38 kinases

1999 • 121 citations

Involvement of Phosphatidylinositide 3′-Kinase and Rac in Platelet-Derived Growth Factor-Induced Actin Reorganization and Chemotaxis

1997 • 120 citations

Tyrosine Phosphorylation of the vav Proto-oncogene Product Links FcεRI to the Rac1-JNK Pathway

1997 • 113 citations

Epidermal Growth Factor Induction of the c-jun Promoter by a Rac Pathway

1998 • 102 citations

Signaling from G Protein-coupled Receptors to ERK5/Big MAPK 1 Involves Gαq and Gα12/13 Families of Heterotrimeric G Proteins

2000 • 92 citations

Lysophosphatidic Acid Induces Threonine Phosphorylation of Tiam1 in Swiss 3T3 Fibroblasts via Activation of Protein Kinase C

1997 • 86 citations

Tiam1 Overexpression Potentiates Heregulin-induced Lymphoid Enhancer Factor-1/β-Catenin Nuclear Signaling in Breast Cancer Cells by Modulating the Intercellular Stability

2001 • 86 citations

Avian myelocytomatosis and erythroblastosis viruses lack the transforming gene src of avian sarcoma viruses

1978 • 63 citations

Activation of the Guanine Nucleotide Exchange Factor Dbl Following ACK1-Dependent Tyrosine Phosphorylation

2000 • 61 citations

v-Abl Activates c-myc Transcription through the E2F Site

1995 • 57 citations

Effector domain mutants of Rho dissociate cytoskeletal changes from nuclear signaling and cellular transformation

1998 • 52 citations

Stimulation of Ras Guanine Nucleotide Exchange Activity of Ras-GRF1/CDC25Mm upon Tyrosine Phosphorylation by the Cdc42-regulated Kinase ACK1

2000 • 47 citations

Metabotropic glutamate receptors activate phospholipase D in astrocytes through a protein kinase C-dependent and Rho-independent pathway

2003 • 24 citations

p60v-src and serum control cell shape and apoptosis via distinct pathways in quail neuroretina cells

2002 • 9 citations