A conserved regulatory unit implicated in tissue-specific gene expression in Drosophila and man.

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

1986 • 6,284 citations

Genetic Transformation of Drosophila with Transposable Element Vectors

1982 • 2,995 citations

Transposition of Cloned P Elements into Drosophila Germ Line Chromosomes

1982 • 1,560 citations

Identification of two distinct regulatory regions adjacent to the human β-interferon gene

1983 • 1,076 citations

Isolation of a recombinant copy of the gene encoding C/EBP.

1988 • 1,003 citations

Scissors-Grip Model for DNA Recognition by a Family of Leucine Zipper Proteins

1989 • 996 citations

Calcium phosphate-mediated gene transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA.

1988 • 897 citations

The rapid generation of oligonucleotide-directed mutations at high frequency using phosphorothioate-modified DNA

1985 • 849 citations

Analysis of P transposable element functions in drosophila

1984 • 733 citations

An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2

1987 • 699 citations

The DNA Binding Domain of the Rat Liver Nuclear Protein C/EBP Is Bipartite

1989 • 661 citations

Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein.

1989 • 641 citations

Identification of a rat liver nuclear protein that binds to the enhancer core element of three animal viruses.

1987 • 631 citations

Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes.

1989 • 587 citations

Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes.

1989 • 545 citations

In situ detection of sequence-specific DNA binding activity specified by a recombinant bacteriophage.

1988 • 535 citations

Characterization of a “silencer” in yeast: A DNA sequence with properties opposite to those of a transcriptional enhancer

1985 • 531 citations

GAL4 activates transcription in Drosophila

1988 • 521 citations

CCAAT/enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells.

1989 • 488 citations

The messenger RNA for alcohol dehydrogenase in Drosophila melanogaster differs in its 5′ end in different developmental stages

1983 • 415 citations

Mutually exclusive interaction of the CCAAT-binding factor and of a displacement protein with overlapping sequences of a histone gene promoter

1987 • 407 citations

A genetic analysis of extinction: Trans-dominant loci regulate expression of liver-specific traits in hepatoma hybrid cells

1984 • 365 citations

Transcriptional regulation of a pair-rule stripe in Drosophila.

1991 • 354 citations

Synergistic activation and repression of transcription by Drosophila homeobox proteins

1989 • 353 citations

Identification and characterization of a novel repressor of beta-interferon gene expression.

1991 • 351 citations

New heat shock puffs and β=galactosidase activity resulting from transformation of Drosophila with an hsp70-lacZ hybrid gene

1983 • 323 citations

Active repression of transcription by the engrailed homeodomain protein.

1991 • 248 citations

Correct developmental expression of a cloned alcohol dehydrogenase gene transduced into the drosophila germ line

1983 • 248 citations

Characterization of drosophila transcription factors that activate the tandem promoters of the alcohol dehydrogenase gene

1985 • 229 citations

Analysis of Krüppel protein distribution during early Drosophila development reveals posttranscriptional regulation

1987 • 222 citations

Proteins that bind to Drosophila chorion cis-regulatory elements: a new C2H2 zinc finger protein and a C2C2 steroid receptor-like component.

1990 • 221 citations

Activation and repression of transcription by homoeodomain-containing proteins that bind a common site

1988 • 217 citations

A tissue-specific transcription enhancer from the Drosophila yolk protein 1 gene

1986 • 188 citations

Independent control elements that determine yolk protein gene expression in alternative Drosophila tissues.

1985 • 158 citations

The functional BPV-1 E2 trans-activating protein can act as a repressor by preventing formation of the initiation complex.

1991 • 154 citations

Repression of HIV-1 Transcription by a Cellular Protein

1991 • 151 citations

Two genetically defined trans-acting loci coordinately regulate overlapping sets of liver-specific genes

1990 • 149 citations

Role of transcriptional interference in the Drosophila melanogaster Adh promoter switch

1989 • 138 citations

The expression of the gene coding for alcohol dehydrogenase during the development of Drosophila melanogaster

1986 • 126 citations

Physical and enzymic properties of a class II alcohol dehydrogenase isozyme of human liver: .pi.-ADH

1984 • 112 citations

Tissue-specific expression of the rat albumin gene: genetic control of its extinction in microcell hybrids.

1986 • 100 citations

Analysis of autosomal dosage compensation involving the alcohol dehydrogenase locus in Drosophila melanogaster.

1990 • 90 citations

Regulatory elements involved in Drosophila Adh gene expression are conserved in divergent species and separate elements mediate expression in different tissues.

1986 • 89 citations

A genetic analysis of extinction: trans-regulation of 16 liver-specific genes in hepatoma-fibroblast hybrid cells.

1987 • 67 citations

DNA regions that regulate the ovarian transcriptional specificity of Drosophila yolk protein genes.

1989 • 53 citations

Identification of cis-regulatory elements required for larval expression of the Drosophila melanogaster alcohol dehydrogenase gene.

1990 • 51 citations

Tse-2: a trans-dominant extinguisher of albumin gene expression in hepatoma hybrid cells.

1989 • 45 citations

Trans Activation of Human Alcohol Dehydrogenase Gene Expression in Hepatoma Cells by C/EBP Molecules Bound in a Novel Arrangement Just 5' and 3' to the TATA Box

1990 • 27 citations

Developmental Control of Drosophila Yolk Protein 1 Gene by cis-acting DNA Elements

1985 • 25 citations

Both early and late Drosophila chorion gene promoters confer correct temporal, tissue and sex specificity on a reporter Adh gene.

1988 • 23 citations