Circadian Timing in Animals

The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor

1997 • 3,702 citations

Clock Mutants of Drosophila melanogaster

1971 • 2,191 citations

A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells

1998 • 1,954 citations

Role of the CLOCK Protein in the Mammalian Circadian Mechanism

1998 • 1,915 citations

Transplanted Suprachiasmatic Nucleus Determines Circadian Period

1990 • 1,788 citations

Mutagenesis and Mapping of a Mouse Gene, Clock , Essential for Circadian Behavior

1994 • 1,570 citations

Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms

1995 • 1,437 citations

Positional Cloning of the Mouse Circadian Gene

1997 • 1,335 citations

A Differential Response of Two Putative Mammalian Circadian Regulators, mper1and mper2, to Light

1997 • 883 citations

Three period Homologs in Mammals: Differential Light Responses in the Suprachiasmatic Circadian Clock and Oscillating Transcripts Outside of Brain

1998 • 867 citations

Light-Induced Resetting of a Mammalian Circadian Clock Is Associated with Rapid Induction of the Transcript

1997 • 866 citations

Closing the Circadian Loop: CLOCK-Induced Transcription of Its Own Inhibitors per and tim

1998 • 799 citations

Circadian oscillation of a mammalian homologue of the Drosophila period gene

1997 • 782 citations

Two period Homologs: Circadian Expression and Photic Regulation in the Suprachiasmatic Nuclei

1997 • 763 citations

The basic-helix–loop–helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors

1998 • 761 citations

A Mutant Drosophila Homolog of Mammalian Clock Disrupts Circadian Rhythms and Transcription of period and timeless

1998 • 718 citations

A Mutation of the Circadian System in Golden Hamsters

1988 • 693 citations

RIGUI, a Putative Mammalian Ortholog of the Drosophila period Gene

1997 • 664 citations

Functional Identification of the Mouse Circadian Clock Gene by Transgenic BAC Rescue

1997 • 664 citations

CYCLE Is a Second bHLH-PAS Clock Protein Essential for Circadian Rhythmicity and Transcription of Drosophila period and timeless

1998 • 631 citations

Independent Photoreceptive Circadian Clocks Throughout Drosophila

1997 • 628 citations

Loss of Circadian Behavioral Rhythms and per RNA Oscillations in the Drosophila Mutant timeless

1994 • 627 citations

The melatonin rhythm-generating enzyme: molecular regulation of serotonin N-acetyltransferase in the pineal gland.

1997 • 552 citations

Spectral sensitivity of a novel photoreceptive system mediating entrainment of mammalian circadian rhythms

1984 • 520 citations

Cellular Construction of a Circadian Clock: Period Determination in the Suprachiasmatic Nuclei

1997 • 504 citations

Neural control of the pineal gland

1995 • 381 citations

Expression of the period clock gene within different cell types in the brain of Drosophila adults and mosaic analysis of these cells' influence on circadian behavioral rhythms

1992 • 326 citations

Circadian transcription of the cholesterol 7 alpha hydroxylase gene may involve the liver-enriched bZIP protein DBP.

1993 • 293 citations

GENETIC AND MOLECULAR ANALYSIS OF CIRCADIAN RHYTHMS

1996 • 267 citations

A Diurnal Rhythm of Stimulatory Input to the Hypothalamo–Pituitary–Adrenal System as Revealed by Timed Intrahypothalamic Administration of the Vasopressin V₁Antagonist

1996 • 264 citations

Extraocular Circadian Phototransduction in Humans

1998 • 244 citations

From the gene to behavior.

1971 • 241 citations

Circadian Clock Neurons in the Silkmoth Antheraea pernyi: Novel Mechanisms of Period Protein Regulation

1996 • 235 citations

Melatonin and circadian control in mammals

1989 • 213 citations

Molecular Neurobiology and Genetics of Circadian Rhythms in Mammals

1995 • 198 citations

Melatonin: Generation and Modulation of Avian Circadian Rhythms

1997 • 173 citations

Rhythmic transcription: the molecular basis of circadian melatonin synthesis

1997 • 157 citations

Transcriptional control of circadian hormone synthesis via the CREM feedback loop

1996 • 148 citations

The two PAR leucine zipper proteins, TEF and DBP, display similar circadian and tissue-specific expression, but have different target promoter preferences.

1996 • 145 citations

Role of the suprachiasmatic nuclei in the circadian system of the house sparrow, Passer domesticus

1982 • 145 citations

Phase Shifting of the Circadian Clock by Induction of the Drosophila period Protein

1994 • 145 citations

Circadian clocks in prokaryotes

1996 • 140 citations

The Mel1a melatonin receptor gene is expressed in human suprachiasmatic nuclei

1996 • 139 citations

A Screen for Genes Induced in the Suprachiasmatic Nucleus by Light

1998 • 110 citations

Role of Neural Cell Adhesion Molecule and Polysialic Acid in Mouse Circadian Clock Function

1997 • 107 citations

The tim Mutant of the Drosophila Rhythm Gene timeless Manifests Allele-Specific Interactions with period Gene Mutants

1996 • 103 citations

The rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distributions and target preferences.

1995 • 99 citations

Circadian clock in cell culture: II. In vitro photic entrainment of melatonin oscillation from dissociated chick pineal cells

1988 • 99 citations

Circadian-clock regulation of gene expression

1993 • 90 citations

Central clocking

1997 • 87 citations

Melatonin, the pineal gland, and circadian rhythms.

1993 • 77 citations

Circadian Entrainment and Phase Shifting in Mammals with Melatonin

1997 • 76 citations

Multioscillatory Circadian Organization in a Vertebrate,Iguana iguana

1998 • 70 citations

Coordinate Regulation of Lipogenesis, the Assembly and Secretion of Apolipoprotein B-containing Lipoproteins by Sterol Response Element Binding Protein 1

1997 • 68 citations

Endocrine Mechanisms of Blood Pressure Rhythms

1996 • 68 citations

A Drosophila circadian clock.

1996 • 65 citations

Adapting to phase shifts, I. An experimental model for jet lag and shift work

1996 • 61 citations

Molecular control of circadian rhythms

1995 • 60 citations

Synchronization of Circadian Rhythms of House Sparrows by Oral Melatonin: Effects of Changing Period

1995 • 53 citations

Circadian locomotor rhythms in the desert iguana I. The role of the eyes and the pineal

1990 • 46 citations

Direct Link From the Suprachiasmatic Nucleus to Hypothalamic Neurons Projecting to the Spinal Cord: A Combined Tracing Study Using Cholera Toxin Subunit B and Phaseolus vulgaris-Leucoagglutinin

1997 • 43 citations

Circadian locomotor rhythms in the desert iguana

1990 • 43 citations

Circadian Feeding and Locomotor Rhythms in Pigeons and House Sparrows

1992 • 42 citations

Chronobiological Analysis of a New Clock Mutant,Toki, inDrosophila Melanogaster

1994 • 41 citations

Circadian clocks

1997 • 39 citations

Circadian rhythms: From behaviour to molecules

1997 • 38 citations

Circadian rhythms of plasma melatonin in the ruin lizard Podarcis sicula: Effects of pinealectomy

1992 • 34 citations

Molecular anatomy of a light-sensitive circadian pacemaker in Drosophila.

1996 • 33 citations

Chronobiology in endocrinology.

1993 • 29 citations

The Circadian Clock: From Molecules to Behaviour

1995 • 25 citations

Chronotherapy for gastrointestinal cancers

1996 • 24 citations

From the gene to behavior

1971 • 21 citations

Rhythms in morphology and function of hepatocytes

1990 • 20 citations

Coordinate Regulation of Cholesterol 7α-Hydroxylase and HMG-CoA Reductase in the Liver

1997 • 20 citations

Forward genetic approaches to circadian clocks in mice.

1996 • 20 citations

Clinical Chronopharmacology: The Importance of Time in Drug Treatment

2007 • 13 citations

Circadian Rhythms: What makes the clock tick?

1994 • 12 citations

How Hamsters Keep Time: The 6 PM to 6 AM Light-Sensitive Period

1989 • 5 citations