Molecular Neurobiology and Genetics of Circadian Rhythms in Mammals

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

Stimulus-Transcription Coupling in the Nervous System: Involvement of the Inducible Proto-Oncogenes fos and jun

1991 • 2,666 citations

Clock Mutants of Drosophila melanogaster

1971 • 2,191 citations

A functional analysis of circadian pacemakers in nocturnal rodents

1976 • 2,105 citations

Transplanted Suprachiasmatic Nucleus Determines Circadian Period

1990 • 1,788 citations

Suprachiasmatic nucleus : the mind's clock

1991 • 1,730 citations

Genetic Control of the Cell Division Cycle in Yeast

1974 • 1,588 citations

Mutagenesis and Mapping of a Mouse Gene, Clock , Essential for Circadian Behavior

1994 • 1,570 citations

ANIMAL CELL CYCLES AND THEIR CONTROL

1992 • 1,239 citations

Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice

1992 • 1,138 citations

Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels

1990 • 1,103 citations

Temporal Organization: Reflections of a Darwinian Clock-Watcher

1993 • 943 citations

Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor.

1992 • 830 citations

Regulation of CREB Phosphorylation in the Suprachiasmatic Nucleus by Light and a Circadian Clock

1993 • 817 citations

A Mutation of the Circadian System in Golden Hamsters

1988 • 693 citations

Loss of Circadian Behavioral Rhythms and per RNA Oscillations in the Drosophila Mutant timeless

1994 • 627 citations

Negative Feedback Defining a Circadian Clock: Autoregulation of the Clock Gene frequency

1994 • 596 citations

Inducibility and negative autoregulation of CREM: An alternative promoter directs the expression of ICER, an early response repressor

1993 • 592 citations

Light Pulses that Shift Rhythms Induce Gene Expressions in the Suprachiasmatic Nucleus

1990 • 551 citations

A Genetic Linkage Map of the Mouse: Current Applications and Future Prospects

1993 • 549 citations

Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse.

1979 • 526 citations

Photic and circadian regulation of c-fos gene expression in the hamster suprachiasmatic nucleus

1990 • 523 citations

PAS is a dimerization domain common to Drosophila Period and several transcription factors

1993 • 515 citations

Circadian rhythm of firing rate recorded from single cells in the rat suprachiasmatic brain slice

1982 • 511 citations

The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development

1991 • 501 citations

Positional cloning: Let's not call it reverse anymore

1992 • 485 citations

Antibodies to the period gene product of drosophila reveal diverse tissue distribution and rhythmic changes in the visual system

1988 • 396 citations

A novel circadian phenotype based on firefly luciferase expression in transgenic plants.

1992 • 384 citations

Cellular and Molecular Bases of Biological Clocks

1988 • 364 citations

Genetic Dissection of Behavior

1973 • 327 citations

Light regulates expression of a Fos-related protein in rat suprachiasmatic nuclei.

1990 • 287 citations

ISOLATION OF CIRCADIAN CLOCK MUTANTS OF NEUROSPORA CRASSA

1973 • 277 citations

Circadian rhythms of melatonin release from individual superfused chicken pineal glands in vitro.

1980 • 257 citations

The Avian Pineal, a Vertebrate Model System of the Circadian Oscillator: Cellular Regulation of Circadian Rhythms by Light, Second Messengers, and Macromolecular Synthesis

1989 • 244 citations

Forward and Reverse Genetic Approaches to Behavior in the Mouse

1994 • 243 citations

Molecular Cloning of Genes Under Control of the Circadian Clock in Neurospora

1989 • 235 citations

The Neurospora circadian clock-controlled gene, ccg-2, is allelic to eas and encodes a fungal hydrophobin required for formation of the conidial rodlet layer.

1992 • 230 citations

Changes in abundance or structure of the per gene product can alter periodicity of the Drosophila clock

1987 • 227 citations

The Neurospora clock gene frequency shares a sequence element with the Drosophila clock gene period

1989 • 217 citations

Regulation of jun -B Messenger RNA and AP-1 Activity by Light and a Circadian Clock

1992 • 215 citations

Circadian Rhythm in Membrane Conductance Expressed in Isolated Neurons

1993 • 208 citations

Genetic Analysis of Circadian Clocks

1993 • 202 citations

Transplantation of the Cockroach Circadian Pacemaker

1982 • 193 citations

Block of c‐Fos and JunB Expression by Antisense Oligonucleotides Inhibits Light‐induced‐Phase Shifts of the Mammalian Circadian Clock

1995 • 190 citations

Circadian rhythms of vasopressin release from individual rat suprachiasmatic explants in vitro

1986 • 186 citations

Rhythmic regulation of retinal melatonin: Metabolic pathways, neurochemical mechanisms, and the ocular circadian clock

1991 • 167 citations

Molecular mapping of point mutations in the period gene that stop or speed up biological clocks in Drosophila melanogaster.

1987 • 157 citations

Photic induction of Fos protein in the suprachiasmatic nucleus is inhibited by the NMDA receptor antagonist MK-801

1991 • 156 citations

Cellular communication in the circadian clock, the suprachiasmatic nucleus

1993 • 153 citations

NMDA and non-NMDA receptor antagonists inhibit photic induction of fos protein in the hamster suprachiasmatic nucleus

1992 • 152 citations

Phase Shifting of the Circadian Clock by Induction of the Drosophila period Protein

1994 • 145 citations

Light, immediate-early genes, and circadian rhythms

1996 • 145 citations

Regulation of melatonin secretion in a photoreceptive pineal organ: an in vitro study in the pike

1989 • 137 citations

NMDA receptor antagonists block the effects of light on circadian behavior in the mouse

1991 • 135 citations

Circadian variation in photic regulation of immediate-early gene mRNAs in rat suprachiasmatic nucleus cells

1992 • 134 citations

Photic regulation of Fos‐like immunoreactivity in the suprachiasmatic nucleus of the mouse

1992 • 131 citations

Do NMDA receptors mediate the effects of light on circadian behavior?

1990 • 131 citations

A nonphotic stimulus causes instantaneous phase advances of the light- entrainable circadian oscillator of the Syrian hamster but does not induce the expression of c-fos in the suprachiasmatic nuclei

1992 • 131 citations

Genetic Approaches to Circadian Clocks

1982 • 126 citations

Local administration of EAA antagonists blocks light-induced phase shifts and c-fos expression in hamster SCN

1993 • 126 citations

The Role of N‐Methyl‐D‐Aspartate‐Type Glutamatergic Neurotransmission in the Photic Induction of Immediate‐Early Gene Expression in the Suprachiasmatic Nuclei of the Syrian Hamster

1991 • 126 citations

Neurotransmitters In The Mammalian Circadian System

1990 • 118 citations

The Mammalian Circadian System: Models and Physiology

1989 • 115 citations

Chemical mutagenesis and fine-structure functional analysis of the mouse genome

1991 • 110 citations

Circadian clock‐ and phytochrome‐regulated transcription is conferred by a 78 bp cis‐acting domain of the Arabidopsis CAB2 promoter

1994 • 109 citations

Circadian and light-induced expression of immediate early gene mRNAs in the rat suprachiasmatic nucleus

1992 • 109 citations

Long-term cultured neurons from rat suprachiasmatic nucleus retain the capacity for circadian oscillation of vasopressin release

1991 • 107 citations

Closely watched clocks: molecular analysis of circadian rhythms in Neurospora and Drosophila

1990 • 107 citations

The Quail's Eye: A Biological Clock

1990 • 103 citations

GENETICS OF CIRCADIAN RHYTHMS

1990 • 101 citations

Temporal regulation of light-induced fos and fos-like protein expression in the ventrolateral subdivision of the rat suprachiasmatic nucleus

1994 • 94 citations

The role of the transcriptional activator protein DBP in circadian liver gene expression

1992 • 93 citations

Neurospora crassa clock-controlled genes are regulated at the level of transcription.

1991 • 93 citations

Different populations of cells in the suprachiasmatic nuclei express c-fos in association with light-induced phase delays and advances of the free-running activity rhythm in hamsters

1992 • 93 citations

Photic induction and circadian expression of Fos-like protein. Immunohistochemical study in the retina and suprachiasmatic nuclei of hamster

1993 • 90 citations

Circadian-clock regulation of gene expression

1993 • 90 citations

Biological Clocks in the Retina: Cellular Mechanisms of Biological Timekeeping

1993 • 86 citations

Compositional changes of AP-1 DNA-binding proteins are regulated by light in a mammalian circadian clock

1993 • 78 citations

On the nature of the circadian clock in mammals

1993 • 72 citations

Alteration of the Phase and Period of a Circadian Oscillator by a Reversible Transcription Inhibitor

1991 • 72 citations

Anisomycin, an inhibitor of protein synthesis, perturbs the phase of a mammalian circadian pacemaker

1987 • 68 citations

Transplantation: a new tool in the analysis of the mammalian hypothalamic circadian pacemaker

1991 • 59 citations

Circadian rhythms: From gene expression to behavior

1991 • 57 citations

A cholinergic antagonist, mecamylamine, blocks light-induced Fos immunoreactivity in specific regions of the hamster suprachiasmatic nucleus

1993 • 46 citations

A clinician's primer on the circadian clock: its localization, function, and resetting.

1993 • 37 citations

Neural Organization and Cellular Mechanisms of Circadian Pacemakers

1984 • 35 citations

The Hunt for Mechanisms of Circadian Timing in the Eye of Aplysia

1992 • 27 citations

Involvement of proteins in light resetting ocular circadian oscillators of Aplysia

1990 • 25 citations

An Antibody to theDrosophila PeriodProtein Labels Antigens in the Suprachiasmatic Nucleus of the Rat

1992 • 25 citations

Phase shifting the circadian clock with cycloheximide: response of hamster with an intact or a split rhythm of locomotor activity

1989 • 23 citations

Circadian regulation of per repeat mRNA in the suprachiasmatic nucleus of rat brain

1993 • 13 citations

Biological Rhythms and Sleep Disorders in Man: The Delayed Sleep Phase Syndrome

1993 • 10 citations

Deleted Work

1955 • 0 citations