At the Cutting Edge What is a cAMP response unit?

CREB: A Stimulus-Induced Transcription Factor Activated by A Diverse Array of Extracellular Signals

1999 • 2,076 citations

Phosphorylated CREB binds specifically to the nuclear protein CBP

1993 • 2,039 citations

Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene

1987 • 1,364 citations

Cyclic AMP-Responsive DNA-Binding Protein: Structure Based on a Cloned Placental cDNA

1988 • 772 citations

REGULATION OF PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP) GENE EXPRESSION

1997 • 726 citations

LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein.

1990 • 599 citations

A vector for expressing GAL4(1–147) fusions tn mammalian cells

1989 • 558 citations

Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. II. Identification of cAMP and glucocorticoid regulatory domains.

1986 • 427 citations

cAMP stimulates transcription of the gene for cytosolic phosphoenolpyruvate carboxykinase in rat liver nuclei.

1982 • 410 citations

The role of the CCAAT/enhancer-binding protein in the transcriptional regulation of the gene for phosphoenolpyruvate carboxykinase (GTP).

1990 • 210 citations

Cyclic AMP induction of phosphoenolpyruvate carboxykinase (GTP) gene transcription is mediated by multiple promoter elements.

1991 • 210 citations

Relative roles of CCAAT/enhancer-binding protein beta and cAMP regulatory element-binding protein in controlling transcription of the gene for phosphoenolpyruvate carboxykinase (GTP).

1993 • 190 citations

Multihormonal regulation of phosphoenolpyruvate carboxykinase-chloramphenicol acetyltransferase fusion genes. Insulin's effects oppose those of cAMP and dexamethasone.

1987 • 155 citations

Phosphoenolpyruvate Carboxykinase (GTP): the Gene and the Enzyme

1994 • 152 citations

Identification of multiple protein binding domains in the promoter-regulatory region of the phosphoenolpyruvate carboxykinase (GTP) gene

1989 • 152 citations

Phosphorylation of CCAAT-enhancer binding protein by protein kinase C attenuates site-selective DNA binding.

1992 • 124 citations

Role of the Isoforms of CCAAT/Enhancer-binding Protein in the Initiation of Phosphoenolpyruvate Carboxykinase (GTP) Gene Transcription at Birth

1997 • 105 citations

Hypoglycemia and impaired hepatic glucose production in mice with a deletion of the C/EBPβ gene

1999 • 90 citations

CCAAT/Enhancer-binding Protein β Is an Accessory Factor for the Glucocorticoid Response from the cAMP Response Element in the Rat Phosphoenolpyruvate Carboxykinase Gene Promoter

1999 • 88 citations

The cAMP Response Element Binding Protein Synergizes with Other Transcription Factors to Mediate cAMP Responsiveness

1995 • 83 citations

Further Characterization of the Glucocorticoid Response Unit in the Phosphoenolpyruvate Carboxykinase Gene. The Role of the Glucocorticoid Receptor-Binding Sites

1998 • 81 citations

Effect of hormones on transcription of the gene for cytosolic phosphoenolpyruvate carboxykinase (GTP) in rat kidney

1985 • 80 citations

Role of CCAAT Enhancer-binding Protein β in the Thyroid Hormone and cAMP Induction of Phosphoenolpyruvate Carboxykinase Gene Transcription

1999 • 67 citations

The α-Isoform of the CCAAT/Enhancer-binding Protein Is Required for Mediating cAMP Responsiveness of the Phosphoenolpyruvate Carboxykinase Promoter in Hepatoma Cells

1996 • 60 citations

Characterization of CCAAT/Enhancer-binding Protein α as a Cyclic AMP-responsive Nuclear Regulator

1998 • 59 citations

Evidence for the involvement of at least two distinct transcription factors, one of which is liver-enriched, for the activation of the phosphoenolpyruvate carboxykinase gene promoter by cAMP.

1993 • 43 citations

Hormonal Regulation of the Phosphoenolpyruvate Carboxykinase Gene

2000 • 35 citations

Characterization of the liver-specific component of the cAMP response unit in the phosphoenolpyruvate carboxykinase (GTP) gene promoter.

1994 • 33 citations

cAMP activation of phosphoenolpyruvate carboxykinase transcription in renal LLC-PK1-F+ cells

1996 • 14 citations

Hormone response units: one plus one equals more than two.

1998 • 14 citations

Further Characterization of the Glucocorticoid Response Unit in the Phosphoenolpyruvate Carboxykinase Gene. The Role of the Glucocorticoid Receptor-Binding Sites

1998 • 14 citations