Positional Cloning of the Mouse Circadian Gene

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Basic local alignment search tool

1990 • 87,358 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

1989 • 2,706 citations

Transplanted Suprachiasmatic Nucleus Determines Circadian Period

1990 • 1,788 citations

Suprachiasmatic nucleus : the mind's clock

1991 • 1,730 citations

Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector.

1992 • 1,651 citations

Mutagenesis and Mapping of a Mouse Gene, Clock , Essential for Circadian Behavior

1994 • 1,570 citations

Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC Gene

1992 • 1,510 citations

The mutational spectrum of single base-pair substitutions in mRNA splice junctions of human genes: Causes and consequences

1992 • 1,338 citations

Cloning the Differences Between Two Complex Genomes

1993 • 1,301 citations

Functional inactivation of genes by dominant negative mutations

1987 • 1,174 citations

A genetic map of the mouse suitable for typing intraspecific crosses.

1992 • 1,114 citations

Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels

1990 • 1,103 citations

Current Protocols in Human Genetics

2001 • 1,023 citations

Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

1991 • 963 citations

The essentials of DNA methylation

1992 • 960 citations

Temporal Organization: Reflections of a Darwinian Clock-Watcher

1993 • 943 citations

Messenger RNA degradation in eukaryotes

1993 • 858 citations

Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor.

1992 • 830 citations

Interpreting cDNA sequences: Some insights from studies on translation

1996 • 785 citations

Neurophysiology of the suprachiasmatic circadian pacemaker in rodents

1989 • 737 citations

Circadian Rhythms in Cultured Mammalian Retina

1996 • 710 citations

A Mutation of the Circadian System in Golden Hamsters

1988 • 693 citations

Functional Identification of the Mouse Circadian Clock Gene by Transgenic BAC Rescue

1997 • 664 citations

Negative Feedback Defining a Circadian Clock: Autoregulation of the Clock Gene frequency

1994 • 596 citations

Further studies on the nature and causes of gene mutations.

1932 • 524 citations

PAS is a dimerization domain common to Drosophila Period and several transcription factors

1993 • 515 citations

Characterization of a Subset of the Basic-Helix-Loop-Helix-PAS Superfamily That Interacts with Components of the Dioxin Signaling Pathway

1997 • 510 citations

The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development

1991 • 501 citations

Current protocols in human genetics

1995 • 498 citations

Functional Interference between Hypoxia and Dioxin Signal Transduction Pathways: Competition for Recruitment of the Arnt Transcription Factor

1996 • 449 citations

The AH-receptor: genetics, structure and function

1993 • 437 citations

Temporal phosphorylation of the Drosophila period protein.

1994 • 410 citations

Antibodies to the period gene product of drosophila reveal diverse tissue distribution and rhythmic changes in the visual system

1988 • 396 citations

DNA Binding Specificities and Pairing Rules of the Ah Receptor, ARNT, and SIM Proteins

1995 • 388 citations

Rhythmic Expression of timeless : A Basis for Promoting Circadian Cycles in period Gene Autoregulation

1995 • 368 citations

Isolation of timeless by PER Protein Interaction: Defective Interaction Between timeless Protein and Long-Period Mutant PER ^L

1995 • 364 citations

Circadian rhythm mutations in Drosophila melanogaster affect short-term fluctuations in the male's courtship song.

1980 • 347 citations

Yeast artificial chromosome libraries containing large inserts from mouse and human DNA.

1991 • 331 citations

Regulation of Nuclear Entry of the Drosophila Clock Proteins Period and Timeless

1996 • 322 citations

Circadian timekeeping in BALB/c and C57BL/6 inbred mouse strains

1990 • 308 citations

Resetting the Drosophila Clock by Photic Regulation of PER and a PER-TIM Complex

1996 • 272 citations

GENETIC AND MOLECULAR ANALYSIS OF CIRCADIAN RHYTHMS

1996 • 267 citations

trachealess encodes a bHLH-PAS protein that is an inducer of tracheal cell fates in Drosophila.

1996 • 264 citations

Positional Cloning and Sequence Analysis of the Drosophila Clock Gene, timeless

1995 • 262 citations

Forward and Reverse Genetic Approaches to Behavior in the Mouse

1994 • 243 citations

Trippings along the trail to the molecular mechanisms of biological clocks

1995 • 242 citations

A Circadian Enhancer Mediates PER-Dependent mRNA Cycling in Drosophila melanogaster

1997 • 237 citations

Constitutive overexpression of the Drosophila period protein inhibits period mRNA cycling.

1994 • 223 citations

Circadian oscillations in period gene mRNA levels are transcriptionally regulated.

1992 • 212 citations

DNA purification and isolation using a solid-phase

1994 • 207 citations

Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system

1997 • 200 citations

Molecular Neurobiology and Genetics of Circadian Rhythms in Mammals

1995 • 198 citations

Protein-protein interaction via PAS domains: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex.

1995 • 187 citations

F0 Membrane Domain of ATP Synthase from Bovine Heart Mitochondria: Purification, Subunit Composition, and Reconstitution with F1-ATPase

1994 • 163 citations

The Mouse Clock Mutation Behaves as an Antimorph and Maps Within the W19H Deletion, Distal of Kit

1997 • 159 citations

Organization of the Mammalian Circadian System

2007 • 155 citations

The Drosophila bendless gene encodes a neural protein related to ubiquitin-conjugating enzymes

1993 • 134 citations

Isolation, characterization, and expression of cDNAs encoding the medaka (Oryzias latipes) ovarian follicle cytochrome P-450 aromatase

1996 • 106 citations

Mouse Growth Hormone-Releasing Hormone: Precursor Structure and Expression in Brain and Placenta

1989 • 95 citations

Construction of a large-insert yeast artificial chromosome library of the rat genome

1997 • 92 citations

Circadian Clock Genes Are Ticking

1992 • 79 citations

Construction of a mouse yeast artificial chromosome library in a recombination–deficient strain of yeast

1992 • 77 citations

Construction of a large-insert yeast artificial chromosome library of the mouse genome

1993 • 75 citations

A Drosophila circadian clock.

1996 • 65 citations

Fishing for complements: finding genes by direct selection

1994 • 64 citations

Circadian rhythms: From gene expression to behavior

1991 • 57 citations

Cloning and Expression of cDNA Encoding a Human Ubiquitin-Conjugating Enzyme Similar to the Drosophila bendless Gene Product

1996 • 38 citations

Anecdotal, Historical and Critical Commentaries on Genetics : Molecular Genetics of Mus musculus: Point Mutagenesis and Millimorgans

1987 • 32 citations

The Sox gene family and its expression during embryogenesis in the teleost fish, medaka (Oryzias latipes)

1995 • 29 citations

A 1.8-Mb YAC contig spanning three members of the receptor tyrosine kinase gene family (Pdgfra, Kit, and Flk1) on mouse chromosome 5

1995 • 23 citations

Messenger RNA expressed in mouse teratocarcinoma stem cells and down-regulated by a tumor-promoting phorbol ester codes for a novel transmembrane protein

1988 • 4 citations

Deleted Work

1955 • 0 citations