Interleukin-6-induced Tethering of STAT3 to the LAP/C/EBPβ Promoter Suggests a New Mechanism of Transcriptional Regulation by STAT3

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6

1994 • 2,037 citations

A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family.

1990 • 1,517 citations

DNA Binding of the Glucocorticoid Receptor Is Not Essential for Survival

1998 • 1,081 citations

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

1994 • 1,015 citations

Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors

1995 • 992 citations

Association and Activation of Jak-Tyk Kinases by CNTF-LIF-OSM-IL-6 β Receptor Components

1994 • 972 citations

Specific Inhibition of Stat3 Signal Transduction by PIAS3

1997 • 971 citations

Association of Transcription Factor APRF and Protein Kinase Jak1 with the Interleukin-6 Signal Transducer gp130

1994 • 822 citations

Biological Role of the CCAAT/Enhancer-binding Protein Family of Transcription Factors

1998 • 799 citations

Interleukin 6 and its Receptor: Ten Years Later

1998 • 774 citations

Three-dimensional structure of the Stat3β homodimer bound to DNA

1998 • 769 citations

IL-6-Induced Homodimerization of gp130 and Associated Activation of a Tyrosine Kinase

1993 • 730 citations

Functional interactions between Stat5 and the glucocorticoid receptor

1996 • 681 citations

Two Signals Are Necessary for Cell Proliferation Induced by a Cytokine Receptor gp130: Involvement of STAT3 in Anti-Apoptosis

1996 • 661 citations

The Role of C/EBP Isoforms in the Control of Inflammatory and Native Immunity Functions

1998 • 661 citations

IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to CEBP

1990 • 637 citations

ATF3 and stress responses.

1999 • 621 citations

A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells.

1996 • 589 citations

Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6.

1993 • 587 citations

A vector for expressing GAL4(1–147) fusions tn mammalian cells

1989 • 558 citations

Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level.

1993 • 543 citations

Defective TNF-α-Induced Apoptosis in STAT1-Null Cells Due to Low Constitutive Levels of Caspases

1997 • 508 citations

Allosteric effects of DNA on transcriptional regulators

1998 • 488 citations

Calcium-Regulated Phosphorylation Within the Leucine Zipper of C/EBPβ

1992 • 398 citations

cAMP stimulates the C/EBP-related transcription factor rNFIL-6 to trans-locate to the nucleus and induce c-fos transcription.

1991 • 388 citations

Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain

1993 • 345 citations

CREB Activation Induces Adipogenesis in 3T3-L1 Cells

2000 • 324 citations

Differential expression of three C/EBP isoforms in multiple tissues during the acute phase response.

1992 • 313 citations

Differential Activation of Acute Phase Response Factor/STAT3 and STAT1 via the Cytoplasmic Domain of the Interleukin 6 Signal Transducer gp130

1996 • 310 citations

STAT3 as an Adapter to Couple Phosphatidylinositol 3-Kinase to the IFNAR1 Chain of the Type I Interferon Receptor

1997 • 263 citations

The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family.

1994 • 251 citations

Differential Activation of Acute Phase Response Factor/Stat3 and Stat1 via the Cytoplasmic Domain of the Interleukin 6 Signal Transducer gp130

1996 • 239 citations

STAT3 Acts as a Co-activator of Glucocorticoid Receptor Signaling

1997 • 236 citations

NF-IL6 and NF-kappa B in cytokine gene regulation.

1997 • 234 citations

Stat Protein Transactivation Domains Recruit p300/CBP through Widely Divergent Sequences

1999 • 228 citations

Interacting Regions in Stat3 and c-Jun That Participate in Cooperative Transcriptional Activation

1999 • 224 citations

Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activation.

1996 • 223 citations

NF-IL6 and NF-κB in Cytokine Gene Regulation

1997 • 196 citations

CREB Controls LAP/C/EBPβ Transcription

1997 • 189 citations

CCAAT Enhancer-binding Protein β and GATA-4 Binding Regions within the Promoter of the Steroidogenic Acute Regulatory Protein (StAR) Gene Are Required for Transcription in Rat Ovarian Cells

1999 • 171 citations

Interleukin-6-Specific Activation of the C/EBPδ Gene in Hepatocytes Is Mediated by Stat3 and Sp1

1998 • 163 citations

Autoregulation of the Stat3 Gene through Cooperation with a cAMP-responsive Element-binding Protein

1998 • 163 citations

Interaction of ATF6 and serum response factor

1997 • 163 citations

CHOP Enhancement of Gene Transcription by Interactions with Jun/Fos AP-1 Complex Proteins

1999 • 138 citations

Role of CAAT-enhancer binding protein isoforms in the cytokine regulation of acute-phase plasma protein genes.

1992 • 132 citations

p38 Mitogen-activated Protein Kinase Mediates the Transcriptional Induction of the Atrial Natriuretic Factor Gene through a Serum Response Element

1998 • 128 citations

Mutational Analysis of Acute-Phase Response Factor/Stat3 Activation and Dimerization

1997 • 121 citations

Transcription factor activity of STAT proteins: structural requirements and regulation by phosphorylation and interacting proteins

1999 • 111 citations

CCAAT/Enhancer-binding Proteins Regulate Expression of the Human Steroidogenic Acute Regulatory Protein (StAR) Gene

1999 • 99 citations

CCAAT/Enhancer-binding Proteins Are Mediators in the Protein Kinase A-dependent Activation of the Decidual Prolactin Promoter

1999 • 92 citations

C/EBP-β/LAP Controls Down-regulation of Albumin Gene Transcription during Liver Regeneration

1996 • 81 citations

IL-6-inducible complexes on an IL-6 response element of the junB promoter contain Stat3 and 36 kDa CRE-like site binding protein(s).

1996 • 79 citations

Ethanol rapidly inhibits IL‐6‐activated STAT3 and C/EBP mRNA expression in freshly isolated rat hepatocytes

1999 • 72 citations

Acute Phase Proteins and Transformed Cells

1997 • 71 citations

Induction of the C/EBP Gene by Dexamethasone and Glucagon in Primary-Cultured Rat Hepatocytes

1996 • 70 citations

Expressions of CCAAT/Enhancer-binding Proteins β and δ and Their Activities Are Intensified by cAMP Signaling as Well as Ca2+/Calmodulin Kinases Activation in Hippocampal Neurons

1998 • 66 citations

The Designer Cytokine Hyper-Interleukin-6 Is a Potent Activator of STAT3-dependent Gene Transcription in Vivoand in Vitro

1999 • 65 citations

Intracellular localization and DNA-binding properties of human papillomavirus type 18 E6 protein expressed with a baculovirus vector

1989 • 63 citations

Two Control Elements in the Hepatitis B Virus S–Promoter Are Important for Full Promoter Activity Mediated by Ccaat–Binding Factor

1999 • 56 citations

CCAAT/Enhancer-Binding Protein Gene Expression Is Mediated by APRF/STAT3

1997 • 52 citations

Transcription of a Minimal Promoter from the NF-IL6 Gene Is Regulated by CREB/ATF and SP1 Proteins in U937 Promonocytic Cells

1998 • 42 citations

Isoform-Specific Regulation of the CCAAT/Enhancer-Binding Protein Family of Transcription Factors by 3′,5′-Cyclic Adenosine Monophosphate in Sertoli Cells*

1999 • 40 citations

Autoregulated Induction of the Acute-Phase Response Transcription Factor Gene,agp/ebp

1995 • 36 citations

Transactivation of LAP/NF-IL6 Is Mediated by an Acidic Domain in the N-terminal Part of the Protein

1995 • 29 citations

Transcriptional Induction of theagp/ebp(c/ebpβ) Gene by Hepatocyte Growth Factor

1997 • 17 citations