Colon cancer chemopreventive drugs modulate integrin-mediated signaling pathways.

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

1997 • 3,847 citations

Fruit, vegetables, and cancer prevention: A review of the epidemiological evidence

1992 • 3,313 citations

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

1995 • 2,308 citations

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1995 • 1,810 citations

A rapid in vitro assay for quantitating the invasive potential of tumor cells.

1987 • 1,787 citations

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1994 • 1,590 citations

Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential

1997 • 1,411 citations

Integrins and anoikis

1997 • 1,145 citations

Aspirin and the Risk of Colorectal Cancer in Women

1995 • 1,116 citations

Control of adhesion-dependent cell survival by focal adhesion kinase.

1996 • 1,113 citations

Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.

1998 • 998 citations

Integrin-mediated Signals Regulated by Members of the Rho Family of GTPases

1998 • 615 citations

Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin

1997 • 612 citations

Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn

1996 • 595 citations

Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis

1998 • 593 citations

Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis.

1996 • 549 citations

pp125^FAK-Dependent Tyrosine Phosphorylation of Paxillin Creates a High-Affinity Binding Site for Crk

1995 • 534 citations

Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation.

1996 • 514 citations

Identification of p130Cas as a Mediator of Focal Adhesion Kinase–promoted Cell Migration

1998 • 501 citations

Extracellular Matrix Survival Signals Transduced by Focal Adhesion Kinase Suppress p53-mediated Apoptosis

1998 • 496 citations

A mechanism for regulation of the adhesion-associated protein tyrosine kinase pp125FAK

1996 • 488 citations

Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis

1988 • 486 citations

Integrin cytoplasmic domains: mediators of cytoskeletal linkages and extra- and intracellular initiated transmembrane signaling

1993 • 447 citations

The APC gene product in normal and tumor cells.

1993 • 436 citations

Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas.

1995 • 423 citations

Induction of p130^cas Signaling Complex Formation upon Integrin-Mediated Cell Adhesion: a Role for Src Family Kinases

1996 • 422 citations

Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells.

1995 • 420 citations

Interaction of Focal Adhesion Kinase with Cytoskeletal Protein Talin

1995 • 393 citations

Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation.

1999 • 376 citations

Inhibition of pp125FAK in cultured fibroblasts results in apoptosis.

1996 • 371 citations

p130Cas, a Substrate Associated with v-Src and v-Crk, Localizes to Focal Adhesions and Binds to Focal Adhesion Kinase

1996 • 364 citations

Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest, and p53 induction.

1997 • 352 citations

Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding.

1996 • 347 citations

Regulation of the Cell Cycle by Focal Adhesion Kinase

1998 • 346 citations

Fibronectin and Its Integrin Receptors in Cancer

1999 • 338 citations

Expression of focal adhesion kinase gene and invasive cancer

1993 • 335 citations

APC mutations in colorectal tumors with mismatch repair deficiency.

1996 • 329 citations

Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis

2000 • 322 citations

Modulation of apoptosis by sulindac, curcumin, phenylethyl-3-methylcaffeate, and 6-phenylhexyl isothiocyanate: apoptotic index as a biomarker in colon cancer chemoprevention and promotion.

1997 • 301 citations

Integrin-mediated Activation of Focal Adhesion Kinase Is Required for Signaling to Jun NH2-terminal Kinase and Progression through the G1 Phase of the Cell Cycle

1999 • 275 citations

Attenuation of the expression of the focal adhesion kinase induces apoptosis in tumor cells.

1996 • 265 citations

The effects of sulindac on colorectal proliferation and apoptosis in familial adenomatous polyposis

1995 • 253 citations

A role for Jun-N-terminal kinase in anoikis; suppression by bcl-2 and crmA.

1996 • 250 citations

Dismantling Cell–Cell Contacts during Apoptosis Is Coupled to a Caspase-dependent Proteolytic Cleavage of β-Catenin

1997 • 232 citations

Soy, its components, and cancer prevention: a review of the in vitro, animal, and human data.

1998 • 186 citations

Enhancement of experimental colon cancer by genistein.

1997 • 185 citations

Inhibitory effect of caffeic acid esters on azoxymethane-induced biochemical changes and aberrant crypt foci formation in rat colon.

1993 • 181 citations

Tyrosine phosphorylation is involved in reorganization of the actin cytoskeleton in response to serum or LPA stimulation

1994 • 147 citations

The sulfide metabolite of sulindac prevents tumors and restores enterocyte apoptosis in a murine model of familial adenomatous polyposis

1998 • 142 citations

Antioxidants reduce cyclooxygenase-2 expression, prostaglandin production, and proliferation in colorectal cancer cells.

1998 • 135 citations

Antioxidants Inhibit Interleukin-1-induced Cyclooxygenase and Nitric-oxide Synthase Expression in Rat Mesangial Cells

1996 • 130 citations

Sulindac sulfide inhibits Ras signaling

1998 • 128 citations

A role for epidermal growth factor receptor, c-Src and focal adhesion kinase in an in vitro model for the progression of colon cancer

1997 • 123 citations

Chemopreventive efficacy of sulindac sulfone against colon cancer depends on time of administration during carcinogenic process.

1999 • 110 citations

Genistein-stimulated adherence of prostate cancer cells is associated with the binding of focal adhesion kinase to beta-l-integrin

1996 • 84 citations

Focal Adhesion and Stress Fiber Formation Is Regulated by Tyrosine Phosphatase Activity

1996 • 81 citations

The effect of soy isoflavones on the development of intestinal neoplasia in ApcMin mouse

1998 • 71 citations

Genotype-phenotype correlation in murine Apc mutation: differences in enterocyte migration and response to sulindac.

1999 • 68 citations

Mutational analysis of p73 and p53 in human cancer cell lines

1999 • 64 citations

Caffeic acid phenethyl ester inhibits proliferation of human keratinocytes and interferes with the EGF regulation of ornithine decarboxylase.

1995 • 48 citations

Correlations between the expression, phosphotyrosine content and enzymatic activity of focal adhesion kinase, pp125FAK, in tumor and nontransformed cells.

1996 • 30 citations

Effects of modulation of tyrosine phosphorylation on brush border enzyme activity in human Caco-2 intestinal epithelial cells

1998 • 19 citations

Decreased HER-2 tyrosine kinase expression in rectal mucosa of FAP patients following low-dose sulindac chemoprevention

1998 • 12 citations

APC and Intestinal Carcinogenesis Insights from Animal Models

1999 • 9 citations