Modulation of apoptosis by sulindac, curcumin, phenylethyl-3-methylcaffeate, and 6-phenylhexyl isothiocyanate: apoptotic index as a biomarker in colon cancer chemoprevention and promotion.

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

1995 • 2,308 citations

Cancer statistics, 1996

1996 • 1,807 citations

Treatment of Colonic and Rectal Adenomas with Sulindac in Familial Adenomatous Polyposis

1993 • 1,739 citations

Aspirin Use and Reduced Risk of Fatal Colon Cancer

1991 • 1,695 citations

Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound.

1995 • 682 citations

Inhibition of apoptosis during development of colorectal cancer.

1995 • 548 citations

Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells.

1995 • 420 citations

Identification of candidate cancer chemopreventive agents and their evaluation in animal models and human clinical trials: a review.

1990 • 402 citations

Caffeic acid is a selective inhibitor for leukotriene biosynthesis

1984 • 349 citations

Natural antioxidants. III. Antioxidative components isolated from rhizome of Curcuma longa L.

1985 • 311 citations

Evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation.

1986 • 304 citations

Chemopreventive effect of turmeric against stomach and skin tumors induced by chemical carcinogens in Swiss mice

1992 • 299 citations

The effects of sulindac on colorectal proliferation and apoptosis in familial adenomatous polyposis

1995 • 253 citations

Internal Disintegration Model of Cytotoxic Lymphocyte-Induced Target Damage

1983 • 225 citations

The molecular biology of carcinogenesis

1993 • 223 citations

Inhibition by dietary curcumin of azoxymethane-induced ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon

1993 • 218 citations

Inhibition of apoptosis as a mechanism of tumor promotion

1994 • 192 citations

Nicotine inhibition of apoptosis suggests a role in tumor promotion

1993 • 177 citations

Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells.

1995 • 175 citations

Differential growth inhibition by the aspirin metabolite salicylate in human colorectal tumor cell lines: enhanced apoptosis in carcinoma and in vitro-transformed adenoma relative to adenoma relative to adenoma cell lines.

1996 • 173 citations

Demonstration of extensive chromatin cleavage in transplanted Morris hepatoma 7777 tissue: apoptosis or necrosis?

1993 • 141 citations

Effect of caffeic acid esters on carcinogen-induced mutagenicity and human colon adenocarcinoma cell growth

1992 • 120 citations

The antibacterial action of honey. An in vitro study.

1985 • 96 citations

Chemoprevention of colon carcinogenesis by phenylethyl-3-methylcaffeate.

1995 • 87 citations

Effects of isothiocyanates on tumorigenesis by benzo[a]pyrene in murine tumor models

1993 • 75 citations

Apoptosis mediates the selective toxicity of caffeic acid phenethyl ester (CAPE) toward oncogene-transformed rat embryo fibroblast cells.

1995 • 49 citations

The role of chemoprevention in cancer control.

1996 • 29 citations

Bile Salt Induction of Apoptosis in Goblet Cells of the Normal Human Colonic Mucosa: Relevance to Colon Cancer

1995 • 6 citations