Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest, and p53 induction.

New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening

1990 • 9,412 citations

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

1995 • 2,308 citations

Treatment of Colonic and Rectal Adenomas with Sulindac in Familial Adenomatous Polyposis

1993 • 1,739 citations

Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining.

1975 • 1,734 citations

Aspirin and the potential role of prostaglandins in colon cancer.

1992 • 694 citations

Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway

1996 • 613 citations

Sulindac for polyposis of the colon

1983 • 521 citations

A Hypothesis: Nonsteroidal Anti-Inflammatory Drugs Reduce the Incidence of Large-Bowel Cancer

1991 • 519 citations

Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis.

1995 • 433 citations

Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells.

1995 • 420 citations

Inhibitory effect of aspirin on azoxymethane-induced colon carcinogenesis in F344 rats

1993 • 353 citations

Dose-related inhibition of colon carcinogenesis by dietary piroxicam, a nonsteroidal antiinflammatory drug, during different stages of rat colon tumor development.

1987 • 305 citations

Molecular controls of growth arrest and apoptosis: p53-dependent and independent pathways.

1995 • 282 citations

The effects of sulindac on colorectal proliferation and apoptosis in familial adenomatous polyposis

1995 • 253 citations

Effects of Long-term Sulindac Therapy on Colonic Polyposis

1991 • 202 citations

Alteration of tumor growth by aspirin and indomethacin: Studies with two transplantable tumors in mouse

1976 • 157 citations

Inhibition of colon carcinogenesis by prostaglandin synthesis inhibitors and related compounds

1992 • 153 citations

Complete reversion and prevention of rectal adenomas in colectomized patients with familial adenomatous polyposis by rectal low-dose sulindac maintenance treatment

1995 • 117 citations

Do NSAIDs exert their colon cancer chemoprevention activities through the inhibition of mucosal prostaglandin synthetase?

1995 • 101 citations

The NSAID sulindac reverses rectal adenomas in colectomized patients with familial adenomatous polyposis: clinical results of a dose-finding study on rectal sulindac administration

1993 • 99 citations

Sulindac Inhibits the Rate of Growth and Appearance of Colon Tumors in the Rat

1991 • 89 citations

Inhibition of mammary carcinogenesis in rats by sulfone metabolite of sulindac.

1995 • 75 citations

Evidence that indomethacin reversibly inhibits cell growth in the G1 phase of the cell cycle

1979 • 69 citations

Antitumor activity of indomethacin in mice bearing advanced colon 26 carcinoma compared with those with early transplants.

1989 • 53 citations

Inhibition of colon cancer precursors in the rat by sulindac sulphone is not dependent on inhibition of prostaglandin synthesis

1996 • 46 citations

Prevention and treatment of primary intestinal tumors in rats by piroxicam.

1989 • 44 citations

Piroxicam decreases postirradiation colonic neoplasia in the rat

1990 • 11 citations