Tyrosine phosphorylation is involved in reorganization of the actin cytoskeleton in response to serum or LPA stimulation

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Genistein, a specific inhibitor of tyrosine-specific protein kinases.

1987 • 3,773 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

1988 • 2,137 citations

Signal transduction from the extracellular matrix.

1993 • 1,727 citations

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

1992 • 1,456 citations

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.

1992 • 1,330 citations

Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

1989 • 846 citations

Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation

1992 • 831 citations

Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin.

1992 • 811 citations

Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase.

1992 • 743 citations

Microinjection of recombinant p21rho induces rapid changes in cell morphology.

1990 • 720 citations

Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins.

1991 • 713 citations

Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets.

1992 • 669 citations

Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils.

1990 • 615 citations

Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors

1989 • 607 citations

Blocking of EGF-Dependent Cell Proliferation by EGF Receptor Kinase Inhibitors

1988 • 593 citations

Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein.

1991 • 578 citations

Receptor-coupled signal transduction in human polymorphonuclear neutrophils: effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness.

1990 • 567 citations

The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells.

1989 • 529 citations

Bombesin stimulation of DNA synthesis and cell division in cultures of Swiss 3T3 cells.

1983 • 470 citations

The insulinomimetic agents H2O2 and vanadate stimulate protein tyrosine phosphorylation in intact cells.

1990 • 440 citations

Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies.

1991 • 392 citations

Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts.

1993 • 377 citations

The effect of tyrosine-specific protein phosphorylation on the assembly of adherens-type junctions.

1992 • 312 citations

Lysophosphatidic acid stimulates tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130. Signaling pathways and cross-talk with platelet-derived growth factor.

1994 • 264 citations

Cell spreading on extracellular matrix proteins induces tyrosine phosphorylation of tensin

1993 • 253 citations

Tyrosine phosphorylation in T cells is regulated by phosphatase activity: studies with phenylarsine oxide.

1990 • 246 citations

Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the Gi-p21ras pathway.

1994 • 239 citations

Mechanisms of action in NIH-3T3 cells of genistein, an inhibitor of EGF receptor tyrosine kinase activity

1990 • 235 citations

Tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells.

1994 • 214 citations

Studies on a new epidermal growth factor-receptor kinase inhibitor, erbstatin, produced by MH435-hF3.

1986 • 214 citations

ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells.

1993 • 212 citations

Tyrphostins—Potential antiproliferative agents and novel molecular tools

1990 • 177 citations

Modulation of intercellular adherens-type junctions and tyrosine phosphorylation of their components in RSV-transformed cultured chick lens cells.

1991 • 164 citations

LPA: a novel lipid mediator with diverse biological actions

1994 • 139 citations

Inhibition of epidermal growth factor‐induced DNA synthesis by tyrosine kinase inhibitors

1990 • 132 citations

Cytoskeleton-associated cell contacts

1989 • 115 citations

Signal transduction by the platelet integrin alpha IIb beta 3: induction of calcium oscillations required for protein-tyrosine phosphorylation and ligand-induced spreading of stably transfected cells.

1992 • 95 citations

Human T and B Lymphocytes Express a Structurally Conserved Focal Adhesion Kinase, pp125^FAK

1993 • 91 citations

Expression of fibronectin variants in vascular and visceral smooth muscle cells in development

1990 • 85 citations

Phosphotyrosyl turnover in insulin signaling. Characterization of two membrane-bound pp15 protein tyrosine phosphatases from 3T3-L1 adipocytes.

1991 • 79 citations

Erbstatin blocks platelet activating factor‐induced protein‐tyrosine phosphorylation, polyphosphoinositide hydrolysis, protein kinase C activation, serotonin secretion and aggregation of rabbit platelets

1990 • 68 citations

Signaling between the Extracellular Matrix and the Cytoskeleton: Tyrosine Phosphorylation and Focal Adhesion Assembly

1992 • 63 citations

Respiratory burst oxidase of fertilization.

1989 • 63 citations

Kinetic studies of tyrosine kinase inhibition by erbstatin.

1987 • 62 citations

Activation of phosphotyrosine phosphatase activity by reduction of cell-substrate adhesion.

1993 • 58 citations

Signals from focal adhesions

1992 • 55 citations

Tyrphostin inhibits bombesin stimulation of tyrosine phosphorylation, c-fos expression, and DNA synthesis in Swiss 3T3 cells

1993 • 51 citations

Differences in the regulation of endothelin-1- and lysophosphatidic-acid-stimulated Ins(1,4,5)P3 formation in rat-1 fibroblasts

1991 • 48 citations

Inhibition of tyrosine protein kinase by synthetic erbstatin analogs.

1987 • 42 citations

Inhibition of protein kinase c by the tyrosine kinase inhibitor erbstatin

1990 • 42 citations

The undercoat of adherens junctions: A key specialized structure in organogenesis and carcinogenesis.

1990 • 33 citations

pp75: A novel tyrosine-phosphorylated protein that heralds differentiation of HL-60 cells

1991 • 17 citations

Focal adhesions and integrin-mediated cell signaling

1995 • 3 citations