Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1995 • 2,877 citations

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

1994 • 2,553 citations

Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

1996 • 2,387 citations

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

1995 • 2,308 citations

Functions of Ceramide in Coordinating Cellular Responses to Stress

1996 • 1,620 citations

Relation of Meat, Fat, and Fiber Intake to the Risk of Colon Cancer in a Prospective Study among Women

1990 • 1,258 citations

Expression of cyclooxygenase-1 and -2 in human colorectal cancer.

1995 • 1,135 citations

Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.

1986 • 999 citations

Dose‐dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli

1991 • 816 citations

Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse

1993 • 664 citations

Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway

1996 • 613 citations

Altered eicosanoid levels in human colon cancer.

1993 • 571 citations

The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia

1995 • 566 citations

Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis.

1996 • 549 citations

Apoptosis and APC in colorectal tumorigenesis.

1996 • 491 citations

Genetic determinants of p53-induced apoptosis and growth arrest.

1996 • 472 citations

Prostaglandin H synthase 2 is expressed abnormally in human colon cancer: evidence for a transcriptional effect.

1996 • 462 citations

Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis.

1995 • 433 citations

Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells.

1995 • 420 citations

Nonsteroidal Antiinflammatory Drugs Inhibit the Proliferation of Colon Adenocarcinoma Cells: Effects on Cell Cycle and Apoptosis

1996 • 343 citations

Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha.

1994 • 340 citations

Dietary Factors and Risk of Colon Cancer

1994 • 333 citations

Phospholipid precursors of prostaglandins

1968 • 333 citations

Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis

1997 • 327 citations

Chemoprevention of spontaneous intestinal adenomas in the Apc Min mouse model by the nonsteroidal anti-inflammatory drug piroxicam.

1996 • 294 citations

The genetic regulation of apoptosis

1995 • 283 citations

The effects of sulindac on colorectal proliferation and apoptosis in familial adenomatous polyposis

1995 • 253 citations

NONSTEROIDAL ANTI-INFLAMMATORY DRUGS, EICOSANOIDS, AND COLORECTAL CANCER PREVENTION

1996 • 212 citations

Nonsteroidal antiinflammatory drugs cause apoptosis and induce cyclooxygenases in chicken embryo fibroblasts.

1995 • 210 citations

SHORT COMMUNICATION: Sulindac suppresses tumorigenesis in the Min mouse

1996 • 176 citations

Sulindac causes rapid regression of preexisting tumors in Min/+ mice independent of prostaglandin biosynthesis.

1997 • 174 citations

Phospholipase A2 Is Necessary for Tumor Necrosis Factor α-induced Ceramide Generation in L929 Cells

1997 • 161 citations

Effect of harvesting methods, growth conditions and growth phase on diacylglycerol levels in cultured human adherent cells

1988 • 153 citations

NSAID USE AND DECREASED RISK OF GASTROINTESTINAL CANCERS

1996 • 124 citations

Changes in bioactive lipids, alkylacylglycerol and ceramide, occur in HIV-infected cells

1992 • 106 citations

Introduction: Mechanism of Action of NSAIDs

1996 • 96 citations

Chemoprevention of colon cancer by dietary fatty acids

1994 • 74 citations

Kinetics of the tissue distributions of sulindac and metabolites. Relevance to sites and rates of bioactivation.

1980 • 71 citations

IL-3 alters free arachidonic acid generation in C5a-stimulated human basophils.

1993 • 49 citations

NSAID-INDUCED POLYP REGRESSION IN FAMILIAL ADENOMATOUS POLYPOSIS PATIENTS

1996 • 40 citations

Membrane unpacking and the rapid disposal of apoptotic cells

1995 • 26 citations

The Ability to Recognize Phosphatidylserine on Apoptotic Cells Is an Inducible Function in Murine Bone Marrow-derived Macrophages

1993 • 22 citations

New Perspectives on Controlling Progression of Severe Rheumatoid Arthritis--A Summary of the Potential Role of Cyclosporin

1996 • 9 citations

Cited By (0)

No citing papers found in database