Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

Role of cell shape in growth control

1978 • 2,434 citations

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

1988 • 2,137 citations

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1995 • 1,810 citations

Signal transduction from the extracellular matrix.

1993 • 1,727 citations

Integrins: Emerging Paradigms of Signal Transduction

1995 • 1,591 citations

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1994 • 1,590 citations

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

1992 • 1,456 citations

Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

1995 • 1,367 citations

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.

1992 • 1,330 citations

Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage

1986 • 1,206 citations

Integrin function: molecular hierarchies of cytoskeletal and signaling molecules.

1995 • 1,202 citations

Autophosphorylation of the Focal Adhesion Kinase, ppl25^FAK, Directs SH2-Dependent Binding of pp60^src

1994 • 1,168 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

An interaction between alpha-actinin and the beta 1 integrin subunit in vitro.

1990 • 851 citations

Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation

1992 • 831 citations

Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin.

1992 • 811 citations

Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase.

1992 • 743 citations

Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins.

1991 • 713 citations

Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets.

1992 • 669 citations

Integrin-mediated cell adhesion activates mitogen-activated protein kinases.

1994 • 660 citations

Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains.

1995 • 620 citations

Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein.

1991 • 578 citations

pp125^FAK-Dependent Tyrosine Phosphorylation of Paxillin Creates a High-Affinity Binding Site for Crk

1995 • 534 citations

Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase.

1994 • 516 citations

A mechanism for regulation of the adhesion-associated protein tyrosine kinase pp125FAK

1996 • 488 citations

Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase.

1994 • 469 citations

Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation.

1995 • 415 citations

Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions.

1993 • 408 citations

A Link Between Cyclin A Expression and Adhesion-Dependent Cell Cycle Progression

1993 • 399 citations

Interaction of Focal Adhesion Kinase with Cytoskeletal Protein Talin

1995 • 393 citations

C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.

1994 • 391 citations

Cloning and Characterization of Cell Adhesion Kinase β, a Novel Protein-tyrosine Kinase of the Focal Adhesion Kinase Subfamily

1995 • 385 citations

Enhanced proliferative potential in culture of cells from p53-deficient mice.

1993 • 341 citations

Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase.

1995 • 341 citations

Integrin-mediated Cell Adhesion Promotes Tyrosine Phosphorylation of p130Cas, a Src Homology 3-containing Molecule Having Multiple Src Homology 2-binding Motifs

1995 • 340 citations

Characterization of Tyrosine Phosphorylation of Paxillin in Vitro by Focal Adhesion Kinase

1995 • 334 citations

Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain.

1994 • 331 citations

Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: identification of a vinculin and pp125Fak- binding region

1994 • 311 citations

Formation of cell-to-substrate contacts during fibroblast motility: An interference-reflexion study

1980 • 307 citations

Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. Identification of a novel tyrosine kinase as a major substrate.

1992 • 296 citations

Tyrosine Phosphorylation of p130Cas and Cortactin Accompanies Integrin-mediated Cell Adhesion to Extracellular Matrix

1995 • 289 citations

Autonomous Expression of a Noncatalytic Domain of the Focal Adhesion-Associated Protein Tyrosine Kinase pp125^FAK

1993 • 282 citations

Matrix/Integrin Interaction Activates the Mitogen-activated Protein Kinase, p44erk-1 and p42erk-2

1995 • 274 citations

Signal transduction through integrins: A central role for focal adhesion kinase?

1995 • 273 citations

Attenuation of the expression of the focal adhesion kinase induces apoptosis in tumor cells.

1996 • 265 citations

Tyrosine phosphorylation and cytoskeletal reorganization in platelets are triggered by interaction of integrin receptors with their immobilized ligands

1993 • 260 citations

Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts.

1993 • 257 citations

Cell spreading on extracellular matrix proteins induces tyrosine phosphorylation of tensin

1993 • 253 citations

Control of intracellular pH and growth by fibronectin in capillary endothelial cells.

1990 • 241 citations

Analysis of the binding of the Src homology 2 domain of Csk to tyrosine-phosphorylated proteins in the suppression and mitotic activation of c-Src.

1994 • 230 citations

Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 alpha with actin filaments and focal adhesion kinase.

1995 • 229 citations

Cytoskeletal integrity is required throughout the mitogen stimulation phase of the cell cycle and mediates the anchorage-dependent expression of cyclin D1.

1996 • 227 citations

Adhesion-induced tyrosine phosphorylation of the p130 SRC substrate

1995 • 223 citations

Tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells.

1994 • 214 citations

ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells.

1993 • 212 citations

Glass beads load macromolecules into living cells

1987 • 181 citations

The RhoA-dependent assembly of focal adhesions in Swiss 3T3 cells is associated with increased tyrosine phosphorylation and the recruitment of both pp125FAK and protein kinase C-δ to focal adhesions

1994 • 168 citations

Tyrosine phosphorylation is involved in reorganization of the actin cytoskeleton in response to serum or LPA stimulation

1994 • 147 citations

Mapping of the functional determinants of the integrin beta 1 cytoplasmic domain by site-directed mutagenesis.

1990 • 141 citations

In vitro endothelial wound repair. Interaction of cell migration and proliferation.

1990 • 136 citations

Mapping in vivo associations of cytoplasmic proteins with integrin beta 1 cytoplasmic domain mutants.

1995 • 136 citations

Stimulation of tyrosine phosphorylation and accumulation of GTP-bound p21ras upon antibody-mediated alpha 2 beta 1 integrin activation in T-lymphoblastic cells.

1993 • 127 citations

Syringe loading introduces macromolecules into living mammalian cell cytosol

1992 • 121 citations

Accumulation of talin in nodes at the edge of the lamellipodium and separate incorporation into adhesion plaques at focal contacts in fibroblasts.

1991 • 116 citations

Sphingosine induces p125FAK and paxillin tyrosine phosphorylation, actin stress fiber formation, and focal contact assembly in Swiss 3T3 cells.

1994 • 113 citations

Microinjection of antibodies against talin inhibits the spreading and migration of fibroblasts

1992 • 109 citations

Evidence for an actin-containing cytoplasmic precursor of the focal contact and the timing of incorporation of vinculin at the focal contact.

1987 • 102 citations

Signal transduction by the platelet integrin alpha IIb beta 3: induction of calcium oscillations required for protein-tyrosine phosphorylation and ligand-induced spreading of stably transfected cells.

1992 • 95 citations

Identification and Characterization of a High-Affinity Interaction Between v-Crk and Tyrosine-Phosphorylated Paxillin in CT10-Transformed Fibroblasts

1993 • 71 citations

Signaling between the Extracellular Matrix and the Cytoskeleton: Tyrosine Phosphorylation and Focal Adhesion Assembly

1992 • 63 citations

Signals from focal adhesions

1992 • 55 citations

Identification and subcellular location of talin in various cell types and tissues by means of [125I]vinculin overlay, immunoblotting and immunocytochemistry.

1988 • 49 citations

PP125FAK Tyrosine kinase activity is not required for the assembly of f-actin stress fibres and focal adhesions in cultured mouse aortic smooth muscle cells

1995 • 37 citations

Molecular Mechanisms Regulating the Vascular Endothelial Cell Motile Response to Injury

1993 • 32 citations

Cytoplasmic pH and anchorage-independent growth induced by v-Ki-ras, v-src or polyoma middle T.

1990 • 25 citations