APC and Intestinal Carcinogenesis Insights from Animal Models

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

1997 • 3,847 citations

Identification and characterization of the familial adenomatous polyposis coli gene

1991 • 2,806 citations

Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

1996 • 2,387 citations

Identification of FAP Locus Genes from Chromosome 5q21

1991 • 2,358 citations

Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

1991 • 1,890 citations

Treatment of Colonic and Rectal Adenomas with Sulindac in Familial Adenomatous Polyposis

1993 • 1,739 citations

A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse

1990 • 1,550 citations

Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC Gene

1992 • 1,510 citations

Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

1996 • 1,382 citations

Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β

1998 • 1,241 citations

Association of the APC Gene Product with β-Catenin

1993 • 1,215 citations

Association of the APC Tumor Suppressor Protein with Catenins

1993 • 1,202 citations

Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein.

1995 • 1,025 citations

Identification of deletion mutations and three new genes at the familial polyposis locus

1991 • 769 citations

Sulindac causes regression of rectal polyps in familial adenomatous polyposis

1991 • 736 citations

Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse

1993 • 664 citations

Alleles of the APC gene: An attenuated form of familial polyposis

1993 • 621 citations

Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin

1997 • 612 citations

Intestinal Tumorigenesis in Compound Mutant Mice of both Dpc4(Smad4) and Apc Genes

1998 • 603 citations

The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia

1995 • 566 citations

Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene.

1995 • 551 citations

Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis.

1996 • 549 citations

Sulindac for polyposis of the colon

1983 • 521 citations

A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors.

1994 • 519 citations

Molecular determinants of dysplasia in colorectal lesions.

1994 • 506 citations

The APC gene product in normal and tumor cells.

1993 • 436 citations

Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors.

1994 • 407 citations

Loss of Apc+ in intestinal adenomas from Min mice.

1994 • 373 citations

Effect of Wheat Fiber and Vitamins C and E on Rectal Polyps in Patients With Familial Adenomatous Polyposis

1989 • 349 citations

Correlation between the location of germ-line mutations in the APC gene and the number of colorectal polyps in familial adenomatous polyposis patients.

1992 • 337 citations

Chemoprevention of spontaneous intestinal adenomas in the Apc Min mouse model by the nonsteroidal anti-inflammatory drug piroxicam.

1996 • 294 citations

Curcumin inhibits cyclooxygenase-2 transcription in bile acid- and phorbol ester-treated human gastrointestinal epithelial cells

1999 • 288 citations

Attenuated familial adenomatous polyposis (AFAP) a phenotypically and genotypically distinctive variant of FAP

1995 • 266 citations

The effects of sulindac on colorectal proliferation and apoptosis in familial adenomatous polyposis

1995 • 253 citations

Inactivation of both APC alleles in human and mouse tumors.

1994 • 248 citations

APC Genotype, Polyp Number, and Surgical Options in Familial Adenomatous Polyposis

1998 • 176 citations

Dimer formation by an N-terminal coiled coil in the APC protein.

1993 • 175 citations

Sulindac causes rapid regression of preexisting tumors in Min/+ mice independent of prostaglandin biosynthesis.

1997 • 174 citations

MSH2 deficiency contributes to accelerated APC-mediated intestinal tumorigenesis.

1996 • 164 citations

Chemoprevention of spontaneous intestinal adenomas in the adenomatous polyposis coli Min mouse model with aspirin☆☆☆

1998 • 156 citations

Apc gene mutation is associated with a dominant-negative effect upon intestinal cell migration.

1997 • 149 citations

The sulfide metabolite of sulindac prevents tumors and restores enterocyte apoptosis in a murine model of familial adenomatous polyposis

1998 • 142 citations

The Intestinal Polyposes

1973 • 134 citations

Aspirin prevents tumors in a murine model of familial adenomatous polyposis

1998 • 124 citations

Correlation between the development of extracolonic manifestations in FAP patients and mutations beyond codon 1403 in the APC gene.

1996 • 92 citations

Administration of an unconjugated bile acid increases duodenal tumors in a murine model of familial adenomatous polyposis

1999 • 89 citations

Suppression of carcinogenesis in the intestines of min mice by the soybean-derived Bowman-Birk inhibitor.

1996 • 80 citations

Effects of p 53 mutations on apoptosis in mouse intestinal and human colonic adenomas

1997 • 72 citations

Genotype-phenotype correlation in murine Apc mutation: differences in enterocyte migration and response to sulindac.

1999 • 68 citations

Overview of screening and management of familial adenomatous polyposis.

1992 • 54 citations

Evidence that the familial adenomatous polyposis gene is involved in a subset of colon cancers with a complementable defect in c-myc regulation.

1989 • 50 citations

Deleted Work

1955 • 0 citations