Dismantling Cell–Cell Contacts during Apoptosis Is Coupled to a Caspase-dependent Proteolytic Cleavage of β-Catenin

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis

1996 • 3,454 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Functional interaction of β-catenin with the transcription factor LEF-1

1996 • 2,847 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1996 • 1,902 citations

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

1997 • 1,848 citations

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

1995 • 1,848 citations

XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

1996 • 1,827 citations

A new member of the frizzled family from Drosophila functions as a Wingless receptor

1996 • 1,489 citations

Morphogenetic roles of classic cadherins

1995 • 1,468 citations

The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species.

1989 • 1,393 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.

1994 • 1,239 citations

Association of the APC Gene Product with β-Catenin

1993 • 1,215 citations

Structural basis of cell-cell adhesion by cadherins

1995 • 1,173 citations

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1996 • 980 citations

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

1994 • 843 citations

Cell binding function of E-cadherin is regulated by the cytoplasmic domain.

1988 • 811 citations

Membrane and Morphological Changes in Apoptotic Cells Regulated by Caspase-Mediated Activation of PAK2

1997 • 742 citations

Alpha 1(E)-catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complex.

1995 • 739 citations

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

1996 • 731 citations

Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor.

1994 • 712 citations

Lack of β-catenin affects mouse development at gastrulation

1995 • 700 citations

Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells.

1995 • 684 citations

Signal transduction through beta-catenin and specification of cell fate during embryogenesis.

1996 • 663 citations

Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin.

1995 • 651 citations

A License to Kill

1996 • 649 citations

E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.

1994 • 647 citations

Inhibition of ICE Family Proteases by Baculovirus Antiapoptotic Protein p35

1995 • 645 citations

Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death

1997 • 635 citations

Prevention of Vertebrate Neuronal Death by the crmA Gene

1994 • 618 citations

Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme.

1994 • 596 citations

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

1996 • 580 citations

Assembly of the cadherin-catenin complex in vitro with recombinant proteins

1994 • 557 citations

Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.

1996 • 529 citations

Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution.

1995 • 524 citations

Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein

1995 • 467 citations

Cadherins

1992 • 437 citations

Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death.

1994 • 424 citations

p60v-src causes tyrosine phosphorylation and inactivation of the N-cadherin-catenin cell adhesion system.

1993 • 421 citations

In vivo analysis of cadherin function in the mouse intestinal epithelium: essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death.

1995 • 416 citations

Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.

1995 • 407 citations

Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherin-catenin adhesion system in a dispersed carcinoma line.

1994 • 405 citations

The roles of catenins in the cadherin-mediated cell adhesion: functional analysis of E-cadherin-alpha catenin fusion molecules.

1994 • 398 citations

Mch3, a novel human apoptotic cysteine protease highly related to CPP32.

1995 • 391 citations

The Baculovirus p35 Protein Inhibits Fas- and Tumor Necrosis Factor-induced Apoptosis

1995 • 366 citations

ICE-like proteases in apoptosis

1995 • 353 citations

DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis.

1996 • 351 citations

The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease.

1996 • 331 citations

ICE-LAP3, a Novel Mammalian Homologue of the Caenorhabditis elegans Cell Death Protein Ced-3 Is Activated during Fas- and Tumor Necrosis Factor-induced Apoptosis

1996 • 327 citations

HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death.

1996 • 318 citations

Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis.

1996 • 318 citations

A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells.

1995 • 313 citations

ICE-LAP6, a Novel Member of the ICE/Ced-3 Gene Family, Is Activated by the Cytotoxic T Cell Protease Granzyme B

1996 • 304 citations

Cleavage of actin by interleukin 1 beta-converting enzyme to reverse DNase I inhibition.

1996 • 298 citations

A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin: a cause of loss of intercellular adhesiveness in human cancer cell lines.

1994 • 284 citations

The genetic regulation of apoptosis

1995 • 283 citations

The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism.

1996 • 279 citations

ICE/CED3-like Proteases as Therapeutic Targets for the Control of Inappropriate Apoptosis

1996 • 267 citations

Microfilament reorganization during apoptosis: the role of Gas2, a possible substrate for ICE-like proteases.

1995 • 265 citations

Bcl-2 expression prevents activation of the ICE protease cascade.

1996 • 254 citations

Microfilament-disrupting agents prevent the formation of apoptotic bodies in tumor cells undergoing apoptosis.

1992 • 250 citations

The segment polarity gene armadillo interacts with the wingless signaling pathway in both embryonic and adult pattern formation

1991 • 247 citations

Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis.

1996 • 247 citations

A 220-kD undercoat-constitutive protein: its specific localization at cadherin-based cell-cell adhesion sites.

1991 • 234 citations

Cytoskeleton—membrane interactions

1996 • 231 citations

A role for the Drosophila segment polarity gene armadillo in cell adhesion and cytoskeletal integrity during oogenesis

1993 • 226 citations

Loss of E-Cadherin-Dependent Cell-Cell Adhesion due to Mutation of the β-Catenin Gene in a Human Cancer Cell Line, HSC-39

1995 • 225 citations

D4-GDI, a Substrate of CPP32, Is Proteolyzed during Fas-induced Apoptosis

1996 • 216 citations

Identification of Actin as a Substrate of ICE and an ICE-like Protease and Involvement of an ICE-like Protease but Not ICE in Vp-16-Induced U937 Apoptosis

1995 • 210 citations

Induction of a secondary body axis in Xenopus by antibodies to beta-catenin.

1993 • 205 citations

Identification of Plakoglobin Domains Required for Association with N-cadherin and α-Catenin

1995 • 144 citations

The REF52 Protein Database

1989 • 131 citations

Gas2, a growth arrest-specific protein, is a component of the microfilament network system

1992 • 121 citations

Resistance of actin to cleavage during apoptosis

1997 • 87 citations