The sulfide metabolite of sulindac prevents tumors and restores enterocyte apoptosis in a murine model of familial adenomatous polyposis

Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

1996 • 2,387 citations

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

1995 • 2,308 citations

Treatment of Colonic and Rectal Adenomas with Sulindac in Familial Adenomatous Polyposis

1993 • 1,739 citations

Aspirin Use and Reduced Risk of Fatal Colon Cancer

1991 • 1,695 citations

A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse

1990 • 1,550 citations

Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC Gene

1992 • 1,510 citations

Expression of cyclooxygenase-1 and -2 in human colorectal cancer.

1995 • 1,135 citations

Aspirin and the Risk of Colorectal Cancer in Women

1995 • 1,116 citations

Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer.

1995 • 837 citations

Sulindac causes regression of rectal polyps in familial adenomatous polyposis

1991 • 736 citations

Altered eicosanoid levels in human colon cancer.

1993 • 571 citations

Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis.

1996 • 549 citations

Inhibition of apoptosis during development of colorectal cancer.

1995 • 548 citations

Sulindac for polyposis of the colon

1983 • 521 citations

Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis.

1995 • 433 citations

Evaluation of cyclooxygenase-2 inhibitor for potential chemopreventive properties in colon carcinogenesis.

1996 • 421 citations

Sulindac for polyposis of the colon

1989 • 418 citations

Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent.

1995 • 400 citations

Loss of Apc+ in intestinal adenomas from Min mice.

1994 • 373 citations

Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels.

1997 • 362 citations

Inhibitory effect of aspirin on azoxymethane-induced colon carcinogenesis in F344 rats

1993 • 353 citations

Dose-related inhibition of colon carcinogenesis by dietary piroxicam, a nonsteroidal antiinflammatory drug, during different stages of rat colon tumor development.

1987 • 305 citations

Chemoprevention of spontaneous intestinal adenomas in the Apc Min mouse model by the nonsteroidal anti-inflammatory drug piroxicam.

1996 • 294 citations

The effects of sulindac on colorectal proliferation and apoptosis in familial adenomatous polyposis

1995 • 253 citations

Sulfone metabolite of sulindac inhibits mammary carcinogenesis.

1997 • 211 citations

Chemical and Biological Studies on Indomethacin, Sulindac and their Analogs

1977 • 196 citations

The use of indomethacin, sulindac, and tamoxifen for the treatment of desmoid tumors associated with familial polyposis

1987 • 163 citations

Inhibition of colon carcinogenesis by prostaglandin synthesis inhibitors and related compounds

1992 • 153 citations

A protective effect of sulindac against chemically‐induced primary colonic tumours in mice

1988 • 140 citations

Identification of the biologically active form of sulindac.

1977 • 136 citations

Antiproliferative effect of nonsteroidal antiinflammatory drugs against human colon cancer cells.

1994 • 109 citations

Inhibition of initiation and promotion by N-methylnitrosourea-induced colon carcinogenesis in rats by non-steroid anti-inflammatory agent indomethacin

1983 • 94 citations

Effect of piroxicam on primary intestinal tumors induced in rats by N-methylnitrosourea

1984 • 90 citations

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

1992 • 81 citations

Influence of various prostaglandin synthesis inhibitors on DMH-induced rat colon cancer

1984 • 78 citations

Inhibition of mammary carcinogenesis in rats by sulfone metabolite of sulindac.

1995 • 75 citations

Aspirin and the Risk of Colorectal Cancer in Women

1996 • 48 citations

Tissue prostaglandin levels in familial adenomatous polyposis patients treated with sulindac

1996 • 43 citations