Fibronectin and Its Integrin Receptors in Cancer

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Geometric Control of Cell Life and Death

1997 • 4,614 citations

Disruption of epithelial cell-matrix interactions induces apoptosis

1994 • 3,167 citations

RGD AND OTHER RECOGNITION SEQUENCES FOR INTEGRINS

1996 • 3,074 citations

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

Role of cell shape in growth control

1978 • 2,434 citations

Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

1994 • 2,293 citations

Cancer Treatment by Targeted Drug Delivery to Tumor Vasculature in a Mouse Model

1998 • 2,040 citations

FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING

1996 • 1,900 citations

Signal transduction from the extracellular matrix.

1993 • 1,727 citations

Integrins: Emerging Paradigms of Signal Transduction

1995 • 1,591 citations

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1994 • 1,590 citations

The extracellular matrix as a cell survival factor.

1993 • 1,541 citations

Tumor Cell Interactions with the Extracellular Matrix During Invasion and Metastasis

1993 • 1,523 citations

Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies

1997 • 1,444 citations

FIBRONECTIN AND ITS RECEPTORS

1988 • 1,336 citations

Organ targeting In vivo using phage display peptide libraries

1996 • 1,198 citations

Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix

1995 • 1,184 citations

Integrins and anoikis

1997 • 1,145 citations

Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor

1985 • 1,119 citations

Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase

1996 • 1,106 citations

Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression.

1989 • 1,073 citations

Maspin, a Serpin with Tumor-Suppressing Activity in Human Mammary Epithelial Cells

1994 • 913 citations

Detection of tumor angiogenesis in vivo by αvβ3-targeted magnetic resonance imaging

1998 • 851 citations

Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin.

1995 • 840 citations

Integrin distribution in malignant melanoma: association of the beta 3 subunit with tumor progression.

1990 • 771 citations

Elevated levels of the α5β1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells

1990 • 746 citations

The Adaptor Protein Shc Couples a Class of Integrins to the Control of Cell Cycle Progression

1996 • 739 citations

αv Integrins as receptors for tumor targeting by circulating ligands

1997 • 738 citations

The TGF-β family of growth and differentiation factors

1987 • 675 citations

A Synthetic Peptide from Fibronectin Inhibits Experimental Metastasis of Murine Melanoma Cells

1986 • 634 citations

The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression.

1995 • 627 citations

Rho-mediated Contractility Exposes a Cryptic Site in Fibronectin and Induces Fibronectin Matrix Assembly

1998 • 589 citations

Integrins and cancer

1996 • 520 citations

Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase.

1994 • 516 citations

Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells.

1994 • 504 citations

Suppression of Integrin Activation: A Novel Function of a Ras/Raf-Initiated MAP Kinase Pathway

1997 • 501 citations

alpha vbeta 3 integrin associates with activated insulin and PDGFbeta receptors and potentiates the biological activity of PDGF

1997 • 493 citations

NF-κB Mediates αvβ3 Integrin-induced Endothelial Cell Survival

1998 • 484 citations

Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases.

1990 • 480 citations

Phage Libraries Displaying Cyclic Peptides with Different Ring Sizes: Ligand Specificities of the RGD-Directed Integrins

1995 • 472 citations

Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein.

1996 • 453 citations

Evidence for In Vivo Phosphorylation of the Grb2 SH2-Domain Binding Site on Focal Adhesion Kinase by Src-Family Protein-Tyrosine Kinases

1996 • 450 citations

Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen.

1994 • 447 citations

αLβ2 Integrin/LFA-1 Binding to ICAM-1 Induced by Cytohesin-1, a Cytoplasmic Regulatory Molecule

1996 • 439 citations

Wound repair in the context of extracellular matrix

1994 • 435 citations

Binding of Transforming Protein, P47 ^gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins

1990 • 433 citations

Induction of p130^cas Signaling Complex Formation upon Integrin-Mediated Cell Adhesion: a Role for Src Family Kinases

1996 • 422 citations

Cell adhesion and the integrin-linked kinase regulate the LEF-1 and β-catenin signaling pathways

1998 • 421 citations

Role of the alpha v beta 3 integrin in human melanoma cell invasion.

1992 • 414 citations

Integrin Activation by R-ras

1996 • 414 citations

Dependence of Cyclin E-CDK2 Kinase Activity on Cell Anchorage

1996 • 371 citations

Inhibition of pp125FAK in cultured fibroblasts results in apoptosis.

1996 • 371 citations

Metalloprotease-Disintegrins: Links to Cell Adhesion and Cleavage of TNFα and Notch

1997 • 363 citations

Association of insulin receptor substrate-1 with integrins

1994 • 362 citations

Detection of occult melanoma cells in blood with a multiple-marker polymerase chain reaction assay.

1995 • 338 citations

Transforming growth factor-beta 1 modulates beta 1 and beta 5 integrin receptors and induces the de novo expression of the alpha v beta 6 heterodimer in normal human keratinocytes: implications for wound healing.

1995 • 324 citations

Inhibition of in vitro tumor cell invasion by Arg-Gly-Asp-containing synthetic peptides [published erratum appears in J Cell Biol 1989 Jun;108(6):following 2546]

1988 • 311 citations

Levels of translatable mRNAs for cell surface protein, collagen precursors, and two membrane proteins are altered in Rous sarcoma virus-transformed chick embryo fibroblasts.

1977 • 309 citations

Integrin-mediated signalling: regulation by protein tyrosine kinases and small GTP-binding proteins

1996 • 305 citations

Superfibronectin is a functionally distinct form of fibronectin

1994 • 300 citations

Distinct localizations of urokinase-type plasminogen activator and its type 1 inhibitor under cultured human fibroblasts and sarcoma cells

1987 • 295 citations

Integrin alpha 5 beta 1 expression negatively regulates cell growth: reversal by attachment to fibronectin.

1995 • 247 citations

TGF-β1 Stimulates Expression of Keratinocyte Integrins During Re-Epithelialization of Cutaneous Wounds

1994 • 246 citations

Ligand occupancy of the alpha-V-beta3 integrin is necessary for smooth muscle cells to migrate in response to insulin-like growth factor.

1996 • 243 citations

Fibronectin Matrix Regulates Activation of RHO and CDC42 GTPases and Cell Cycle Progression

1998 • 234 citations

R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways

1997 • 223 citations

Effect of thrombin treatment of tumor cells on adhesion of tumor cells to platelets in vitro and tumor metastasis in vivo.

1992 • 201 citations

Model study detecting breast cancer cells in peripheral blood mononuclear cells at frequencies as low as 10(-7).

1995 • 201 citations

Integrin and Cadherin Synergy Regulates Contact Inhibition of Migration and Motile Activity

1998 • 192 citations

Farnesyl transferase inhibitors induce apoptosis of Ras-transformed cells denied substratum attachment.

1997 • 184 citations

E‐cadherin as a tumor (invasion) suppressor gene

1995 • 179 citations

Investigation of the biological effects of anti-cell adhesive synthetic peptides that inhibit experimental metastasis of B16-F10 murine melanoma cells.

1988 • 175 citations

Clinical significance of alpha(v)beta3 integrin and intercellular adhesion molecule-1 expression in cutaneous malignant melanoma lesions.

1997 • 174 citations

Cellular tumorigenicity in nude mice. Test of associations among loss of cell-surface fibronectin, anchorage independence, and tumor-forming ability.

1979 • 170 citations

Redirection of tumor metastasis by expression of E-selectin in vivo.

1996 • 169 citations

Complexes of Focal Adhesion Kinase (FAK) and Crk-associated Substrate (p130Cas) Are Elevated in Cytoskeleton-associated Fractions following Adhesion and Src Transformation

1997 • 166 citations

Multiple functional forms of the integrin VLA-2 can be derived from a single alpha 2 cDNA clone: interconversion of forms induced by an anti-beta 1 antibody.

1993 • 141 citations

Anchorage-Dependent Transcription of the Cyclin A Gene

1996 • 136 citations

Increased tumorigenicity of fibronectin receptor deficient Chinese hamster ovary cell variants.

1991 • 133 citations

A polymeric form of fibronectin has antimetastatic effects against multiple tumor types

1996 • 133 citations

Developmental switches in the immune system

1994 • 126 citations

VEGF-mediated tumour angiogenesis: a new target for cancer therapy

1995 • 126 citations

Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cells

1998 • 123 citations

A role for epidermal growth factor receptor, c-Src and focal adhesion kinase in an in vitro model for the progression of colon cancer

1997 • 123 citations

Immunobead-PCR: a technique for the detection of circulating tumor cells using immunomagnetic beads and the polymerase chain reaction.

1993 • 122 citations

Induction of experimental bone metastasis in mice by transfection of integrin alpha 4 beta 1 into tumor cells.

1996 • 116 citations

Epithelial integrins

1996 • 113 citations

The extracellular matrix as a cell cycle control element in atherosclerosis and restenosis.

1997 • 107 citations

Identification of a New Biological Function for the Integrin α_vβ₃: Initiation of Fibronectin Matrix Assembly

1996 • 106 citations

Modulation of cell surface fibronectin assembly sites by lysophosphatidic acid.

1994 • 105 citations

Cloning and Characterization of Lung-Endothelial Cell Adhesion Molecule-1 Suggest It Is an Endothelial Chloride Channel

1997 • 99 citations

Lung endothelial dipeptidyl peptidase IV is an adhesion molecule for lung-metastatic rat breast and prostate carcinoma cells.

1993 • 89 citations

Expression of the Integrin α5 Subunit in HT29 Colon Carcinoma Cells Suppresses Apoptosis Triggered by Serum Deprivation

1996 • 88 citations

Detection of prostatic cells in peripheral blood: correlation with serum concentrations of prostate-specific antigen

1995 • 77 citations

The extracellular matrix as a cell cycle control element in atherosclerosis and restenosis.

1996 • 70 citations

The alpha v beta 3 integrin associates with a 190-kDa protein that is phosphorylated on tyrosine in response to platelet-derived growth factor

1993 • 70 citations

Suppression of transformed phenotypes of human fibrosarcoma cells by overexpression of recombinant fibronectin.

1996 • 54 citations

Fibrinogen influx and accumulation of cross-linked fibrin in mouse carcinomas.

1988 • 51 citations

Endothelial cell membrane vesicles in the study of organ preference of metastasis.

1991 • 50 citations

v-Crk-induced cell transformation: changes in focal adhesion composition and signaling

1997 • 44 citations

Fibronectin Fibrils and Growth Factors Stimulate Anchorage-Independent Growth of a Murine Mammary Carcinoma

1996 • 35 citations

Inhibition of metastatic cell colonization in murine lungs and tumor‐induced morbidity by non‐peptidic Arg‐Gly‐Asp mimetics

1993 • 33 citations

A test of the role of alpha5 integrin/fibronectin interactions in tumorigenesis.

1998 • 33 citations