Control of CFTR Channel Gating by Phosphorylation and Nucleotide Hydrolysis

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.

1982 • 5,284 citations

ABC Transporters: From Microorganisms to Man

1992 • 3,956 citations

Identification of the Cystic Fibrosis Gene: Chromosome Walking and Jumping

1989 • 3,180 citations

THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASES

1989 • 2,518 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

Reconstitution of I _KATP : An Inward Rectifier Subunit Plus the Sulfonylurea Receptor

1995 • 1,703 citations

Protein Kinase C: Structure, Function, and Regulation

1995 • 1,640 citations

Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis

1993 • 1,432 citations

Structural model of ATP-binding proteing associated with cystic fibrosis, multidrug resistance and bacterial transport

1990 • 1,149 citations

Demonstration That CFTR Is a Chloride Channel by Alteration of Its Anion Selectivity

1991 • 1,108 citations

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.

1990 • 1,077 citations

CFTR as a cAMP-Dependent Regulator of Sodium Channels

1995 • 1,074 citations

[3] Protein kinase phosphorylation site sequences and consensus specificity motifs: Tabulations

1991 • 1,036 citations

Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)

1992 • 937 citations

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

1994 • 823 citations

Chloride impermeability in cystic fibrosis

1983 • 750 citations

Association and Stoichiometry of KATP Channel Subunits

1997 • 697 citations

Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutation

1991 • 689 citations

Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel

1991 • 658 citations

CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP

1995 • 647 citations

A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade

1997 • 625 citations

Altered Regulation of Airway Epithelial Cell Chloride Channels in Cystic Fibrosis

1986 • 568 citations

Phosphorylation-regulated CI− channel in CHO cells stably expressing the cystic fibrosis gene

1991 • 564 citations

Crystal structure of active elongation factor Tu reveals major domain rearrangements

1993 • 533 citations

Nucleoside triphosphates are required to open the CFTR chloride channel

1991 • 520 citations

Expression of the cystic fibrosis gene in non-epithelial invertebrate cells produces a regulated anion conductance

1991 • 508 citations

Novel protein serine/threonine phosphatases: Variety is the spice of life

1997 • 503 citations

Chloride Conductance Expressed by ΔF508 and Other Mutant CFTRs In Xenopus Oocytes

1991 • 498 citations

Octameric Stoichiometry of the KATP Channel Complex

1997 • 495 citations

Abnormal Ion Permeation Through Cystic Fibrosis Respiratory Epithelium

1983 • 493 citations

Cystic Fibrosis Heterozygote Resistance to Cholera Toxin in the Cystic Fibrosis Mouse Model

1994 • 483 citations

An Apical PDZ Protein Anchors the Cystic Fibrosis Transmembrane Conductance Regulator to the Cytoskeleton

1998 • 472 citations

The Cystic Fibrosis Transmembrane Conductance Regulator

1993 • 438 citations

The catalytic cycle of P‐glycoprotein

1995 • 432 citations

Cyclic AMP-dependent protein kinase opens chloride channels in normal but not cystic fibrosis airway epithelium

1988 • 419 citations

Defective regulation of outwardly rectifying Cl− channels by protein kinase A corrected by insertion of CFTR

1992 • 418 citations

The spectrum of cystic fibrosis mutations

1992 • 413 citations

A C-terminal motif found in the β ₂ -adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na ⁺ /H ⁺ exchanger regulatory factor family of PDZ proteins

1998 • 406 citations

Intestinal Secretory Defects and Dwarfism in Mice Lacking cGMP-Dependent Protein Kinase II

1996 • 405 citations

Physiological Basis of Cystic Fibrosis: A Historical Perspective

1999 • 400 citations

Protein phosphatases: recent progress.

1991 • 391 citations

Correlating structure and function in ATP-sensitive K+ channels

1998 • 388 citations

RGS9, a GTPase Accelerator for Phototransduction

1998 • 383 citations

Phosphorylation fails to activate chloride channels from cystic fibrosis airway cells

1987 • 341 citations

Structure of the Multidrug Resistance P-glycoprotein to 2.5 nm Resolution Determined by Electron Microscopy and Image Analysis

1997 • 341 citations

Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein

1992 • 328 citations

Phosphorylation of the cystic fibrosis transmembrane conductance regulator.

1992 • 324 citations

Aluminofluoride and beryllofluoride complexes: new phosphate analogs in enzymology

1990 • 307 citations

Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance.

1989 • 303 citations

CFTR and outward rectifying chloride channels are distinct proteins with a regulatory relationship

1993 • 298 citations

Protein kinase A (PKA) still activates CFTR chloride channel after mutagenesis of all 10 PKA consensus phosphorylation sites

1993 • 296 citations

Defective beta adrenergic response of cystic fibrosis sweat glands in vivo and in vitro.

1984 • 296 citations

Peptide binding consensus of the NHE‐RF‐PDZ1 domain matches the C‐terminal sequence of cystic fibrosis transmembrane conductance regulator (CFTR)

1998 • 278 citations

The Two Nucleotide-binding Domains of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Have Distinct Functions in Controlling Channel Activity

1995 • 273 citations

Chloride conductance regulated by cyclic AMP-dependent protein kinase in cardiac myocytes

1989 • 271 citations

Effect of Deleting the R Domain on CFTR-Generated Chloride Channels

1991 • 271 citations

Activation of intestinal CFTR Cl- channel by heat-stable enterotoxin and guanylin via cAMP-dependent protein kinase.

1994 • 268 citations

Inhibitors of protein kinases and phosphatases

1994 • 268 citations

Cl ^- Channels in CF: Lack of Activation by Protein Kinase C and cAMP-Dependent Protein Kinase

1989 • 267 citations

Stimulation of intestinal Cl- transport by heat-stable enterotoxin: activation of cAMP-dependent protein kinase by cGMP

1992 • 265 citations

ATPase Activity of the Cystic Fibrosis Transmembrane Conductance Regulator

1996 • 264 citations

A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus.

1994 • 261 citations

Kinetic and structural analysis of the Mg(2+)-binding site of the guanine nucleotide-binding protein p21H-ras.

1993 • 260 citations

The sulfonylurea receptor

1992 • 257 citations

Autonomic Regulation of a Chloride Current in Heart

1989 • 254 citations

Identification and regulation of the cystic fibrosis transmembrane conductance regulator-generated chloride channel.

1991 • 251 citations

Multi-ion pore behaviour in the CFTR chloride channel

1993 • 250 citations

Evidence for phosphorylation of serine 753 in CFTR using a novel metal‐ion affinity resin and matrix‐assisted laser desorption mass spectrometry

1997 • 247 citations

Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by specific protein kinases and protein phosphatases.

1993 • 246 citations

Maturation and function of cystic fibrosis transmembrane conductance regulator variants bearing mutations in putative nucleotide-binding domains 1 and 2.

1991 • 245 citations

Regulation by ATP and ADP of CFTR Chloride Channels That Contain Mutant Nucleotide-Binding Domains

1992 • 231 citations

Conformational states of CFTR associated with channel gating: The role of ATP binding and hydrolysis

1995 • 230 citations

Regulation of Chloride Channels by Protein Kinase C in Normal and Cystic Fibrosis Airway Epithelia

1989 • 229 citations

More on target with protein phosphorylation: conferring specificity by location.

1996 • 225 citations

Regulation of CFTR chloride channels by syntaxin and Munc18 isoforms

1997 • 219 citations

Cystic fibrosis transmembrane conductance regulator: A chloride channel with novel regulation

1992 • 214 citations

Coupling of CFTR Cl− channel gating to an ATP hydrolysis cycle

1994 • 212 citations

Characterization of the ATPase Activity of Purified Chinese Hamster P-glycoprotein

1994 • 207 citations

cAMP-independent activation of CFTR Cl channels by the tyrosine kinase inhibitor genistein

1995 • 207 citations

Genistein potentiates wild-type and delta F508-CFTR channel activity

1997 • 205 citations

Phosphorylation by Protein Kinase C Is Required For Acute Activation of Cystic Fibrosis Transmembrane Conductance Regulator by Protein Kinase A

1997 • 204 citations

Cystic Fibrosis Transmembrane Conductance Regulator Inverts Protein Kinase A-mediated Regulation of Epithelial Sodium Channel Single Channel Kinetics

1997 • 200 citations

Cl- channel activity in Xenopus oocytes expressing the cystic fibrosis gene.

1991 • 196 citations

Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels.

1995 • 191 citations

Structural model of the nucleotide-binding conserved component of periplasmic permeases.

1991 • 183 citations

Novel pore-lining residues in CFTR that govern permeation and open-channel block

1994 • 178 citations

Rapid Purification of Human P-glycoprotein Mutants Expressed Transiently in HEK 293 Cells by Nickel-Chelate Chromatography and Characterization of their Drug-stimulated ATPase Activities

1995 • 175 citations

Structure-function analysis of the histidine permease and comparison with cystic fibrosis mutations.

1991 • 173 citations

Membrane targeting of cGMP-dependent protein kinase is required for cystic fibrosis transmembrane conductance regulator Cl ⁻ channel activation

1998 • 172 citations

Structural analysis of cloned plasma membrane proteins by freeze-fracture electron microscopy

1998 • 170 citations

The protein kinase A-regulated cardiac CI− channel resembles the cystic fibrosis transmembrane conductance regulator

1992 • 170 citations

Actions of Genistein on Cystic Fibrosis Transmembrane Conductance Regulator Channel Gating

1998 • 162 citations

Effects of pyrophosphate and nucleotide analogs suggest a role for ATP hydrolysis in cystic fibrosis transmembrane regulator channel gating.

1994 • 160 citations

Stimulation of CFTR activity by its phosphorylated R domain

1997 • 159 citations

Altered Drug-stimulated ATPase Activity in Mutants of the Human Multidrug Resistance Protein

1996 • 154 citations

Syntaxin 1A inhibits CFTR chloride channels by means of domain-specific protein–protein interactions

1998 • 153 citations

Phosphatase inhibitors activate normal and defective CFTR chloride channels.

1994 • 153 citations

Modulation of CFTR chloride channels by calyculin A and genistein

1997 • 149 citations

Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by negative charge in the R domain.

1993 • 148 citations

Alternate stimulation of apical CFTR by genistein in epithelia

1996 • 146 citations

Inhibition of epithelial Na⁺currents by intracellular domains of the cystic fibrosis transmembrane conductance regulator

1997 • 142 citations

The CFTR Chloride Channel of Mammalian Heart

1995 • 140 citations

Isotype-specific Activation of Cystic Fibrosis Transmembrane Conductance Regulator-Chloride Channels by cGMP-dependent Protein Kinase II

1995 • 140 citations

Direct action of genistein on CFTR

1997 • 139 citations

Perfection of a synaptic receptor: kinetics and energetics of the acetylcholine receptor.

1989 • 137 citations

CFTR: Mechanism of Anion Conduction

1999 • 136 citations

ATP hydrolysis cycles and mechanism inP-glycoprotein and CFTR

1997 • 130 citations

Endogenous expression of type II cGMP-dependent protein kinase mRNA and protein in rat intestine. Implications for cystic fibrosis transmembrane conductance regulator.

1995 • 127 citations

P-glycoprotein

1995 • 125 citations

Stoichiometry of recombinant cystic fibrosis transmembrane conductance regulator in epithelial cells and its functional reconstitution into cells in vitro.

1994 • 122 citations

Effect of ATP concentration on CFTR Cl- channels: a kinetic analysis of channel regulation

1994 • 122 citations

Chloride‐sensitive nature of the adrenaline‐induced current in guinea‐pig cardiac myocytes.

1990 • 121 citations

The First Nucleotide Binding Fold of the Cystic Fibrosis Transmembrane Conductance Regulator Can Function as an Active ATPase

1995 • 119 citations

Genistein activates CFTR Cl- channels via a tyrosine kinase- and protein phosphatase-independent mechanism

1997 • 117 citations

Mutations in Either Nucleotide-Binding Site of P-glycoprotein (Mdr3) Prevent Vanadate Trapping of Nucleotide at Both Sites

1998 • 115 citations

Phosphorylation by cAMP-Dependent Protein Kinase Causes a Conformational Change in the R Domain of the Cystic Fibrosis Transmembrane Conductance Regulator

1994 • 114 citations

Functionally distinct phospho-forms underlie incremental activation of protein kinase-regulated Cl- conductance in mammalian heart.

1993 • 113 citations

CFTR activation: additive effects of stimulatory and inhibitory phosphorylation sites in the R domain

1997 • 108 citations

P-Glycoprotein Shows Strong Catalytic Cooperativity between the Two Nucleotide Sites

1998 • 107 citations

CFTR channels in immortalized human airway cells

1992 • 106 citations

Calcium/calmodulin-dependent protein kinase I. cDNA cloning and identification of autophosphorylation site.

1993 • 104 citations

Immunochemical localization of calcium/calmodulin‐dependent protein kinase I

1995 • 102 citations

Locating the Anion-selectivity Filter of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Channel

1997 • 99 citations

Differential regulation of single CFTR channels by PP2C, PP2A, and other phosphatases

1998 • 99 citations

cAMP-dependent Protein Kinase-mediated Phosphorylation of Cystic Fibrosis Transmembrane Conductance Regulator Residue Ser-753 and Its Role in Channel Activation

1995 • 97 citations

Regulation of CFTR channel gating

1994 • 95 citations

Glibenclamide, an ATP-Sensitive K ⁺ Channel Blocker, Inhibits Cardiac cAMP-Activated Cl ⁻ Conductance

1995 • 95 citations

Down-regulation of cystic fibrosis gene mRNA transcript levels and induction of the cystic fibrosis chloride secretory phenotype in epithelial cells by phorbol ester

1991 • 94 citations

N-terminal Myristoylation Is Required for Membrane Localization of cGMP-dependent Protein Kinase Type II

1996 • 93 citations

Functional roles of the nucleotide-binding folds in the activation of the cystic fibrosis transmembrane conductance regulator.

1993 • 92 citations

Anion channels activated by adrenaline in cardiac myocytes

1990 • 90 citations

cGMP Stimulation of Cystic Fibrosis Transmembrane Conductance Regulator Cl− Channels Co-expressed with cGMP-dependent Protein Kinase Type II but Not Type Iβ

1997 • 88 citations

Expression of cystic fibrosis transmembrane regulator Cl- channels in heart.

1992 • 87 citations

Activation of the cystic fibrosis transmembrane conductance regulator by cGMP in the human colonic cancer cell line, Caco-2.

1994 • 84 citations

Function of the R Domain in the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel

1997 • 82 citations

ATP alters current fluctuations of cystic fibrosis transmembrane conductance regulator: evidence for a three-state activation mechanism.

1994 • 79 citations

Distribution of the isoprenaline-induced chloride current in rabbit heart

1992 • 78 citations

Specific inhibitors distinguish the chloride channel and drug transporter functions associated with the human multidrug resistance P-glycoprotein.

1993 • 76 citations

Regulation of CFTR ion channel gating by MgATP

1998 • 76 citations

Dibasic protein kinase A sites regulate bursting rate and nucleotide sensitivity of the cystic fibrosis transmembrane conductance regulator chloride channel

1998 • 75 citations

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Anion Binding as a Probe of the Pore

1998 • 75 citations

Forskolin Stimulates Swelling-Induced Chloride Current, Not Cardiac Cystic Fibrosis Transmembrane-Conductance Regulator Current, in Human Cardiac Myocytes

1995 • 74 citations

Alternative splicing of CFTR Cl- channels in heart

1993 • 74 citations

The mechanism of ATP-dependent multidrug transport by P-glycoprotein.

1998 • 74 citations

Protein phosphatase 2C dephosphorylates and inactivates cystic fibrosis transmembrane conductance regulator

1997 • 73 citations

Cystic fibrosis transmembrane conductance regulator expression in human hypothalamus

1998 • 70 citations

Genistein and tyrphostin 47 stimulate CFTR-mediated Cl- secretion in T84 cell monolayers

1995 • 69 citations

CFTR chloride channel activation by genistein: the role of serine/threonine protein phosphatases

1996 • 69 citations

The Giant Membrane Patch

1995 • 68 citations

Regulation of CFTR Cl- channel gating by ADP and ATP analogues.

1995 • 65 citations

The tyrosine kinase p60c-src regulates the fast gate of the cystic fibrosis transmembrane conductance regulator chloride channel

1996 • 65 citations

Protein kinase C regulates the magnitude and stability of CFTR currents in pancreatic duct cells

1995 • 63 citations

Interaction of nucleotides with membrane-associated cystic fibrosis transmembrane conductance regulator

1993 • 61 citations

Cystic fibrosis-- current topics

1993 • 61 citations

Possible regulation of CFTR‐chloride channels by membrane‐bound phosphatases in pancreatic duct cells

1993 • 61 citations

Expression and localization of the cystic fibrosis transmembrane conductance regulator mRNA and its protein in rat brain.

1995 • 60 citations

CFTR chloride channels in human and simian heart

1996 • 60 citations

Sequence homologies between nucleotide binding regions of CFTR and G‐proteins suggest structural and functional similarities

1995 • 59 citations

Characterization of the human multidrug resistance protein containing mutations in the ATP-binding cassette signature region

1997 • 57 citations

Identification of protein kinase A phosphorylation sites on NBD1 and R domains of CFTR using electrospray mass spectrometry with selective phosphate ion monitoring

1996 • 55 citations

CFTR: the nucleotide binding folds regulate the accessibility and stability of the activated state.

1996 • 53 citations

4 Regulation of CFTR Cl− ion channels by phosphorylation and dephosphorylation

1999 • 52 citations

Phosphorylation-dependent Block of Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel by Exogenous R Domain Protein

1996 • 52 citations

A recombinant polypeptide model of the second nucleotide‐binding fold of the cystic fibrosis transmembrane conductance regulator functions as an active ATPase, GTPase and adenylate kinase

1997 • 51 citations

Protein kinase C activates chloride conductance in C127 cells stably expressing the cystic fibrosis gene

1993 • 51 citations

Regulation of CFTR by protein phosphatase 2B and protein kinase C

1998 • 49 citations

Unitary Chloride Channels Activated by Protein Kinase C in Guinea Pig Ventricular Myocytes

1995 • 49 citations

Antisense oligonucleotide to PKC-ε alters cAMP-dependent stimulation of CFTR in Calu-3 cells

1998 • 48 citations

PP2Cγ: a human protein phosphatase with a unique acidic domain¹

1997 • 48 citations

Structural and functional similarities between the nucleotide-binding domains of CFTR and GTP-binding proteins

1995 • 48 citations

Lack of Conventional ATPase Properties in CFTR Chloride Channel Gating

1996 • 47 citations

The CFTR Chloride Channel: Nucleotide Interactions and Temperature-dependent Gating

1998 • 47 citations

Deactivation of CFTR-Cl conductance by endogenous phosphatases in the native sweat duct

1996 • 45 citations

Cystic fibrosis mRNA expression in rat brain

1997 • 42 citations

Expression and Characterization of the NBD1-R Domain Region of CFTR: Evidence for Subunit−Subunit Interactions

1998 • 41 citations

Cystic fibrosis transmembrane conductance regulator activation by cAMP-independent mechanisms

1998 • 41 citations

Chloride conductance in human atrial cells

1995 • 40 citations

PKC regulation of cardiac CFTR Cl⁻channel function in guinea pig ventricular myocytes

1998 • 38 citations

Force-length relation of isometric sarcomeres in fixed-end tetani

1993 • 36 citations

Covalent Modification of the Nucleotide Binding Domains of Cystic Fibrosis Transmembrane Conductance Regulator

1998 • 35 citations

Synergistic activation of non-rectifying small-conductance chloride channels by forskolin and phorbol esters in cell-attached patches of the human colon carcinoma cell line HT-29cl.19A

1993 • 35 citations

A novel model for the first nucleotide binding domain of the cystic fibrosis transmembrane conductance regulator

1997 • 35 citations

Interaction of ATP Binding Sites in the ArsA ATPase, the Catalytic Subunit of the Ars Pump

1996 • 35 citations

Expression of the cystic fibrosis transmembrane conductance regulator gene can be regulated by protein kinase C.

1992 • 34 citations

Endothelin‐induced contractions in placental arteries is mediated by both ET_A‐ and ET_B‐receptors

1998 • 33 citations

Inhibition of P-Glycoprotein ATPase Activity by Procedures Involving Trapping of Nucleotide in Catalytic Sites

1997 • 31 citations

Protein kinase C mediates down-regulation of cystic fibrosis transmembrane conductance regulator levels in epithelial cells

1993 • 31 citations

Human epithelial cystic fibrosis transmembrane conductance regulator without exon 5 maintains partial chloride channel function in intracellular membranes

1996 • 28 citations

Effect of modulation of protein kinase C on the cAMP‐dependent chloride conductance in T84 cells

1992 • 28 citations

5'-Adenylylimidodiphosphate does not activate CFTR chloride channels in cell-free patches of membrane

1993 • 27 citations

Single‐channel study of the cyclic AMP‐regulated chloride current in guinea‐pig ventricular myocytes.

1993 • 27 citations

Substitution of Val20 by Gly in elongation factor Tu

1989 • 26 citations

Catalytic mechanism of P-glycoprotein.

1998 • 25 citations

Cystic Fibrosis Transmembrane Conductance Regulator Is Found Within Brain Ventricular Epithelium and Choroid Plexus

1995 • 24 citations

C-type natriuretic peptide increases chloride permeability in normal and cystic fibrosis airway cells.

1997 • 24 citations

High resolution crystal structure of intact elongation factor Tu in its active form reveals major domain rearrangements

1993 • 21 citations

Synergistic action of cyclic GMP on catecholamine‐induced chloride current in guinea‐pig ventricular cells.

1992 • 21 citations

Identification and partial characterization of a domain in CFTR that may bind cyclic nucleotides directly

1995 • 15 citations

Mutation of Potential Phosphorylation Sites in the Recombinant R Domain of the Cystic Fibrosis Transmembrane Conductance Regulator Has Significant Effects on Domain Conformation

1995 • 15 citations

Preconditioning does not attenuate cardiac dysfunction after global ischaemia in the guinea‐pig

1998 • 8 citations

Cellular Localization of Calmodulin-dependent Protein Kinases I and II to A-cells and D-cells of the Endocrine Pancreas

1998 • 5 citations

Effects of endothelin receptor type A antagonism and nitric oxide synthase inhibition on cerebral blood flow in hypertensive rats

1998 • 5 citations

Protein structure prediction:playing the fold

1996 • 4 citations

Yeast as an expression system for the study of P-glycoprotein and other ABC transporters.

1998 • 2 citations