CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

Identification of the Cystic Fibrosis Gene: Chromosome Walking and Jumping

1989 • 3,180 citations

Extracellular ATP: effects, sources and fate

1986 • 1,666 citations

Chloride impermeability in cystic fibrosis

1983 • 750 citations

Expression cloning of an ATP receptor from mouse neuroblastoma cells.

1993 • 587 citations

Activation by Extracellular Nucleotides of Chloride Secretion in the Airway Epithelia of Patients with Cystic Fibrosis

1991 • 495 citations

Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy

1993 • 439 citations

Defective regulation of outwardly rectifying Cl− channels by protein kinase A corrected by insertion of CFTR

1992 • 418 citations

Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy.

1994 • 410 citations

Non–invasive liposome–mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice

1993 • 400 citations

The cystic fibrosis transmembrane conductance regulator is a dual ATP and chloride channel.

1994 • 354 citations

Expression of the cystic fibrosis transmembrane conductance regulator from a novel adeno-associated virus promoter.

1993 • 337 citations

A Cystic Fibrosis Bronchial Epithelial Cell Line: Immortalization by Adeno-12-SV40 Infection

1991 • 308 citations

CFTR and outward rectifying chloride channels are distinct proteins with a regulatory relationship

1993 • 298 citations

A volume-sensitive chloride conductance in human colonic cell line T84

1989 • 275 citations

Cl ^- Channels in CF: Lack of Activation by Protein Kinase C and cAMP-Dependent Protein Kinase

1989 • 267 citations

G protein-coupled receptors for ATP and other nucleotides: a new receptor family

1994 • 252 citations

Hyperabsorption of Na+ and raised Ca(2+)-mediated Cl- secretion in nasal epithelia of CF mice

1994 • 220 citations

Characterization of human tracheal epithelial cells transformed by an origin-defective simian virus 40.

1988 • 216 citations

Normalization of raised sodium absorption and raised calcium-mediated chloride secretion by adenovirus-mediated expression of cystic fibrosis transmembrane conductance regulator in primary human cystic fibrosis airway epithelial cells.

1995 • 168 citations

Control of CFTR chloride conductance by ATP levels through non-hydrolytic binding

1992 • 167 citations

Variable deletion of exon 9 coding sequences in cystic fibrosis transmembrane conductance regulator gene mRNA transcripts in normal bronchial epithelium.

1991 • 138 citations

Both CFTR and outwardly rectifying chloride channels contribute to cAMP-stimulated whole cell chloride currents

1994 • 138 citations

Chloride secretory response to extracellular ATP in human normal and cystic fibrosis nasal epithelia

1992 • 134 citations

An Immortalized Cystic Fibrosis Tracheal Epithelial Cell Line Homozygous for the ΔF508 CFTR Mutation

1993 • 115 citations

Multiple modes of regulation of airway epithelial chloride secretion by extracellular ATP

1994 • 107 citations

cAMP-activated Cl channels in CFTR-transfected cystic fibrosis pancreatic epithelial cells

1992 • 94 citations

Two cystic fibrosis transmembrane conductance regulator mutations have different effects on both pulmonary phenotype and regulation of outwardly rectified chloride currents.

1995 • 79 citations

Heterotrimeric G proteins, vesicle trafficking, and CFTR Cl- channels

1994 • 75 citations

Mechanism of sodium hyperabsorption in cultured cystic fibrosis nasal epithelium: a patch-clamp study

1994 • 75 citations

Characterization of phosphate:hexose 6-phosphate antiport in membrane vesicles of Streptococcus lactis.

1984 • 51 citations

Inhibition of the Cystic Fibrosis Transmembrane Conductance Regulator By ATP‐Sensitive K⁺ Channel Regulators^a

1993 • 44 citations

Mechanisms of Airway Epithelial Ion Transport

1986 • 26 citations