Cystic fibrosis transmembrane conductance regulator activation by cAMP-independent mechanisms

Measurement of protein using bicinchoninic acid

1985 • 17,516 citations

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

Identification of the Cystic Fibrosis Gene: Genetic Analysis

1989 • 4,105 citations

Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis

1993 • 1,432 citations

Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive

1992 • 1,230 citations

Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel

1991 • 658 citations

CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP

1995 • 647 citations

Nucleoside triphosphates are required to open the CFTR chloride channel

1991 • 520 citations

Chloride Conductance Expressed by ΔF508 and Other Mutant CFTRs In Xenopus Oocytes

1991 • 498 citations

Immunocytochemical localization of the cystic fibrosis gene product CFTR.

1991 • 419 citations

Phosphorylation of the cystic fibrosis transmembrane conductance regulator.

1992 • 324 citations

Identification and regulation of the cystic fibrosis transmembrane conductance regulator-generated chloride channel.

1991 • 251 citations

cAMP-independent activation of CFTR Cl channels by the tyrosine kinase inhibitor genistein

1995 • 207 citations

Genistein potentiates wild-type and delta F508-CFTR channel activity

1997 • 205 citations

A simple assay for agonist-regulated Cl and K conductances in salt-secreting epithelial cells

1990 • 169 citations

Actions of Genistein on Cystic Fibrosis Transmembrane Conductance Regulator Channel Gating

1998 • 162 citations

Modulation of CFTR chloride channels by calyculin A and genistein

1997 • 149 citations

Delta F508-CFTR channels: kinetics, activation by forskolin, and potentiation by xanthines

1996 • 139 citations

Direct action of genistein on CFTR

1997 • 139 citations

Genistein activates CFTR Cl- channels via a tyrosine kinase- and protein phosphatase-independent mechanism

1997 • 117 citations

Functionally distinct phospho-forms underlie incremental activation of protein kinase-regulated Cl- conductance in mammalian heart.

1993 • 113 citations

The substituted benzimidazolone NS004 is an opener of the cystic fibrosis chloride channel

1994 • 105 citations

Regulation of CFTR channel gating

1994 • 95 citations

A1 adenosine-receptor antagonists activate chloride efflux from cystic fibrosis cells.

1992 • 90 citations

CFTR-mediated chloride permeability is regulated by type III phosphodiesterases in airway epithelial cells.

1995 • 86 citations

Direct Activation of Cystic Fibrosis Transmembrane Conductance Regulator Channels by 8-Cyclopentyl-1,3-dipropylxanthine (CPX) and 1,3-Diallyl-8-cyclohexylxanthine (DAX)

1998 • 75 citations

Genistein and tyrphostin 47 stimulate CFTR-mediated Cl- secretion in T84 cell monolayers

1995 • 69 citations

CFTR chloride channel activation by genistein: the role of serine/threonine protein phosphatases

1996 • 69 citations

8-Cyclopentyl-1,3-dipropylxanthine and Other Xanthines Differentially Bind to the Wild-Type and ΔF508 Mutant First Nucleotide Binding Fold (NBF-1) Domains of the Cystic Fibrosis Transmembrane Conductance Regulator

1997 • 69 citations

Activation of endogenous deltaF508 cystic fibrosis transmembrane conductance regulator by phosphodiesterase inhibition.

1996 • 55 citations

Complex effects of inhibitors on cyclic GMP-stimulated cyclic nucleotide phosphodiesterase.

1983 • 50 citations

Tyrosine phosphorylation is a novel pathway for regulation of chloride secretion in shark rectal gland

1995 • 33 citations

Prostaglandin F_2αstimulates CFTR activity by PKA- and PKC-dependent phosphorylation

1998 • 29 citations

8-(4-Chlorophenyl)thio-cyclic AMP is a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA)

1992 • 29 citations