Function of the R Domain in the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

Biophysical and Molecular Mechanisms of Shaker Potassium Channel Inactivation

1990 • 1,528 citations

Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis

1993 • 1,432 citations

Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)

1992 • 937 citations

Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel

1991 • 658 citations

Phosphorylation-regulated CI− channel in CHO cells stably expressing the cystic fibrosis gene

1991 • 564 citations

Destruction of Sodium Conductance Inactivation in Squid Axons Perfused with Pronase

1973 • 540 citations

A characterization of vanadate interactions with the (Na,K)-ATPase. Mechanistic and regulatory implications.

1978 • 520 citations

Nucleoside triphosphates are required to open the CFTR chloride channel

1991 • 520 citations

The ABC of channel regulation

1995 • 375 citations

Phosphorylation of the cystic fibrosis transmembrane conductance regulator.

1992 • 324 citations

Protein kinase A (PKA) still activates CFTR chloride channel after mutagenesis of all 10 PKA consensus phosphorylation sites

1993 • 296 citations

The Two Nucleotide-binding Domains of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Have Distinct Functions in Controlling Channel Activity

1995 • 273 citations

Effect of Deleting the R Domain on CFTR-Generated Chloride Channels

1991 • 271 citations

Regulation of the gating of cystic fibrosis transmembrane conductance regulator C1 channels by phosphorylation and ATP hydrolysis.

1994 • 262 citations

Regulation by ATP and ADP of CFTR Chloride Channels That Contain Mutant Nucleotide-Binding Domains

1992 • 231 citations

Conformational states of CFTR associated with channel gating: The role of ATP binding and hydrolysis

1995 • 230 citations

Coupling of CFTR Cl− channel gating to an ATP hydrolysis cycle

1994 • 212 citations

Effects of pyrophosphate and nucleotide analogs suggest a role for ATP hydrolysis in cystic fibrosis transmembrane regulator channel gating.

1994 • 160 citations

Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by negative charge in the R domain.

1993 • 148 citations

The amino-terminal portion of CFTR forms a regulated CI− channel

1994 • 113 citations

cAMP-dependent Protein Kinase-mediated Phosphorylation of Cystic Fibrosis Transmembrane Conductance Regulator Residue Ser-753 and Its Role in Channel Activation

1995 • 97 citations

Regulation of CFTR channel gating

1994 • 95 citations

Functional roles of the nucleotide-binding folds in the activation of the cystic fibrosis transmembrane conductance regulator.

1993 • 92 citations

Intracellular Loop between Transmembrane Segments IV and V of Cystic Fibrosis Transmembrane Conductance Regulator Is Involved in Regulation of Chloride Channel Conductance State

1995 • 71 citations

Pyrophosphate Stimulates Wild-type and Mutant Cystic Fibrosis Transmembrane Conductance Regulator Cl− Channels

1995 • 62 citations

Interaction of nucleotides with membrane-associated cystic fibrosis transmembrane conductance regulator

1993 • 61 citations

Functions of the Cystic Fibrosis Transmembrane Conductance Regulator Protein

1995 • 52 citations

Phosphorylation-dependent Block of Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel by Exogenous R Domain Protein

1996 • 52 citations

Effect of deletion mutations on the function of CFTR chloride channels.

1993 • 51 citations

Slow conversions among subconductance states of cystic fibrosis transmembrane conductance regulator chloride channel

1996 • 39 citations

AM-loading of fluorescent Ca2+ indicators into intact single fibers of frog muscle

1997 • 38 citations

A two‐domain model for the R domain of the cystic fibrosis transmembrane conductance regulator based on sequence similarities

1994 • 32 citations

Human epithelial cystic fibrosis transmembrane conductance regulator without exon 5 maintains partial chloride channel function in intracellular membranes

1996 • 28 citations