Multi-ion pore behaviour in the CFTR chloride channel

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

Ionic channels of excitable membranes

1985 • 7,199 citations

A general method ofin vitropreparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions

1988 • 2,410 citations

Ionic Blockage of Sodium Channels in Nerve

1973 • 1,590 citations

Demonstration That CFTR Is a Chloride Channel by Alteration of Its Anion Selectivity

1991 • 1,108 citations

The Ionic Channels in Excitable Membranes

1975 • 1,096 citations

Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)

1992 • 937 citations

Mechanism of ion permeation through calcium channels

1984 • 850 citations

Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells

1990 • 706 citations

Non‐selective conductance in calcium channels of frog muscle: calcium selectivity in a single‐file pore.

1984 • 643 citations

Correction of the cystic fibrosis defect in vitro by retrovirus-mediated gene transfer

1990 • 576 citations

Phosphorylation-regulated CI− channel in CHO cells stably expressing the cystic fibrosis gene

1991 • 564 citations

Nucleoside triphosphates are required to open the CFTR chloride channel

1991 • 520 citations

Expression of the cystic fibrosis gene in non-epithelial invertebrate cells produces a regulated anion conductance

1991 • 508 citations

Mutations in CFTR associated with mild-disease-form CI- channels with altered pore properties

1993 • 456 citations

Genetic determination of exocrine pancreatic function in cystic fibrosis.

1992 • 437 citations

Protein kinase A (PKA) still activates CFTR chloride channel after mutagenesis of all 10 PKA consensus phosphorylation sites

1993 • 296 citations

Two types of chloride channel on duct cells cultured from human fetal pancreas

1989 • 224 citations

Low‐conductance chloride channel activated by cAMP in the epithelial cell line T₈₄

1990 • 178 citations

Bicarbonate permeability of the outwardly rectifying anion channel

1989 • 73 citations

Identification of 12 novel mutations in the CFTR gene

1993 • 71 citations

Four new mutations of the CFTR gene (541delC, R347H, R352Q, E585X) detected by DGGE analysis in Italian CF patients, associated with different clinical phenotypes

1992 • 47 citations