Isotype-specific Activation of Cystic Fibrosis Transmembrane Conductance Regulator-Chloride Channels by cGMP-dependent Protein Kinase II

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis

1993 • 1,432 citations

Demonstration That CFTR Is a Chloride Channel by Alteration of Its Anion Selectivity

1991 • 1,108 citations

Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)

1992 • 937 citations

Role of multiple basic residues in determining the substrate specificity of cyclic AMP-dependent protein kinase.

1977 • 844 citations

Cystic fibrosis: molecular biology and therapeutic implications

1992 • 820 citations

Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel

1991 • 658 citations

Guanylyl cyclase is a heat-stable enterotoxin receptor

1990 • 600 citations

Guanylin: an endogenous activator of intestinal guanylate cyclase.

1992 • 575 citations

Heat-stable enterotoxin of Escherichia coli: in vitro effects on guanylate cyclase activity, cyclic GMP concentration, and ion transport in small intestine.

1978 • 563 citations

Nucleoside triphosphates are required to open the CFTR chloride channel

1991 • 520 citations

Role of cyclic GMP in the action of heat-stable enterotoxin of Escherichia coli

1978 • 363 citations

Expression and characterization of the cystic fibrosis transmembrane conductance regulator

1990 • 340 citations

Phosphorylation of the cystic fibrosis transmembrane conductance regulator.

1992 • 324 citations

Intestinal Electrolyte Transport and Diarrheal Disease

1989 • 320 citations

Microinjection of catalytic subunit of cyclic AMP-dependent protein kinase enhances calcium action potentials of bag cell neurons in cell culture

1980 • 306 citations

cGMP-dependent protein kinase, a chimeric protein homologous with two separate protein families

1984 • 292 citations

Activation of intestinal CFTR Cl- channel by heat-stable enterotoxin and guanylin via cAMP-dependent protein kinase.

1994 • 268 citations

Stimulation of intestinal Cl- transport by heat-stable enterotoxin: activation of cAMP-dependent protein kinase by cGMP

1992 • 265 citations

Identification and regulation of the cystic fibrosis transmembrane conductance regulator-generated chloride channel.

1991 • 251 citations

Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by specific protein kinases and protein phosphatases.

1993 • 246 citations

Intestinal Electrolyte Transport and Diarrheal Disease

1989 • 205 citations

The cDNA of the two isoforms of bovine cGMP‐dependent protein kinase

1989 • 195 citations

Cloning and expression of a novel cyclic GMP-dependent protein kinase from mouse brain

1993 • 155 citations

Cloning, expression, and in situ localization of rat intestinal cGMP-dependent protein kinase II.

1994 • 155 citations

Phospholemman expression induces a hyperpolarization-activated chloride current in Xenopus oocytes.

1992 • 148 citations

Molecular cloning and predicted full‐length amino acid sequence of the type Iβ isozyme of cGMP‐dependent protein kinase from human placenta

1989 • 147 citations

The protein IsK is a dual activator of K+ and CI− channels

1993 • 135 citations

Detection of cGMP dependent protein kinase isozymes by specific antibodies

1992 • 127 citations

Endogenous expression of type II cGMP-dependent protein kinase mRNA and protein in rat intestine. Implications for cystic fibrosis transmembrane conductance regulator.

1995 • 127 citations

Immunological distinction between guanosine 3':5'-monophosphate-dependent and adenosine 3':5'-monophosphate-dependent protein kinases.

1980 • 121 citations

Cystic ibrosis: Molecular Biology and Therapeutic Implications

1992 • 118 citations

Textbook of Secretory Diarrhea

1991 • 107 citations

Cyclic nucleotide-dependent phosphorylation of intestinal epithelium proteins

1976 • 96 citations

Regulation of CFTR channel gating

1994 • 95 citations

Activation of the cystic fibrosis transmembrane conductance regulator by cGMP in the human colonic cancer cell line, Caco-2.

1994 • 84 citations

Structural analysis of cGMP-dependent protein kinase using limited proteolysis.

1980 • 60 citations

cGMP-dependent protein kinase regulation of a chloride channel in T84 cells

1992 • 52 citations

Maintenance of contractility in dissociated smooth muscle: low-density cultures in a defined medium

1993 • 50 citations

Effect of Cyclic GMP on Intestinal Transport

1994 • 47 citations

Efficient entrapment of large and small compounds during vesiculation of intestinal microvilli

1986 • 27 citations

Textbook of secretory diarrhea

1991 • 15 citations

Regulation of chloride transport in cultured normal and cystic fibrosis keratinocytes

1992 • 11 citations

Regulation of chloride channels in the human colon carcinoma cell line HT29.cl19A

1993 • 7 citations

Local changes in fractional saturation of cGMP- and cAMP-receptors in intestinal microvilli in response to cholera toxin and heat-stable Escherichia coli toxin

1986 • 3 citations